Solidseq HRR Gene Panel [15 Genes] Test: Booking, Price, and Results
About Solidseq HRR Gene Panel [15 Genes] Test
| Field | Value |
|---|---|
| Also Known As | HRR Gene Panel (15 Genes), Homologous Recombination Repair Gene Panel, HRR Mutation Panel, DNA Damage Repair Gene Panel |
| Sample Type | FFPE tissue block (formalin-fixed paraffin-embedded tumour tissue) |
| Fasting Required | No |
| Report Time | 30 days |
| Recommended For | Adults of all genders diagnosed with or at risk of breast, ovarian, prostate, or pancreatic cancer |
| Price | Starting at ₹24,000 |
What Is a Solidseq HRR Gene Panel [15 Genes] Test?
The Solidseq HRR gene panel [15 genes] test is a specialised genetic test that detects mutations in 15 genes responsible for repairing damaged DNA. These genes belong to the homologous recombination repair (HRR) pathway, a key defence mechanism that keeps DNA stable. Doctors prescribe this test for patients diagnosed with or at risk of certain hereditary cancers, and it is also used to guide targeted cancer treatment decisions. The test uses an FFPE tissue block (a tumour tissue sample preserved in a specific way after biopsy or surgery) as its sample. This test is also known as the HRR gene panel (15 genes), homologous recombination repair gene panel, HRR mutation panel, or DNA damage repair gene panel.
What Does a Solidseq HRR Gene Panel [15 Genes] Test Measure?
This test analyses the following 15 genes, each playing a role in repairing damaged DNA. A fault in any of these genes can impair the body's ability to fix DNA breaks, raising the risk of certain cancers. The 15 genes covered are:
| Gene | Role |
|---|---|
| BRCA1 | Produces proteins that help repair damaged DNA; strongly linked to breast and ovarian cancer risk |
| BRCA2 | A tumour-suppressing gene essential for DNA repair at double-strand breaks |
| ATM | Coordinates DNA damage repair and helps prevent tumour development |
| PALB2 | Works alongside BRCA2 to repair DNA damage |
| CHEK2 | Regulates the cell cycle after DNA damage occurs |
| CDK12 | Involved in responding to DNA damage |
| BRIP1 | Assists BRCA1 in DNA repair processes |
| BARD1 | Partners with BRCA1 to carry out DNA repair |
| FANCD2 | Repairs DNA cross-links, preventing genetic instability |
| MRE11 | Detects and signals DNA breaks for repair |
| NBN | Works within a complex that senses and repairs DNA breaks |
| RAD51B | Assists in DNA strand exchange during repair |
| RAD54L | Supports DNA recombination and repair |
| PPP2R2A | A cell signalling protein involved in regulating repair pathways |
| TP53 | A well-known tumour suppressor gene that controls cell growth and DNA repair |
Why Is a Solidseq HRR Gene Panel [15 Genes] Test Done?
This test is used in oncology settings for both risk assessment and treatment planning. A doctor may recommend it based on personal or family cancer history or when evaluating suitability for specific therapies.
Common Symptoms That May Require This Test
The following clinical situations commonly prompt this test:
- Personal diagnosis of breast, ovarian, prostate, or pancreatic cancer
- Cancer diagnosed at a young age (typically before 50)
- Bilateral cancers (cancer affecting both sides, such as both breasts)
- Strong family history of breast, ovarian, prostate, or pancreatic cancer
- Multiple family members affected by the same or related cancers
- Consideration for PARP inhibitor therapy or platinum-based chemotherapy
- A close relative who has tested positive for an HRR gene mutation
Conditions This Test Can Help Detect
This panel helps identify genetic factors linked to several serious conditions. These include:
- Hereditary breast and ovarian cancer syndrome (HBOC)
- Elevated lifetime risk of breast, ovarian, prostate, or pancreatic cancer due to inherited gene mutations
- Tumour-specific HRR mutations that may make a cancer sensitive to PARP inhibitor therapy or platinum-based chemotherapy
- Metastatic castration-resistant prostate cancer (mCRPC) with HRR mutations
How to Prepare and What to Expect
There is no complex preparation required for the Solidseq HRR gene panel [15 genes] test procedure, but a few steps will help ensure a valid sample is collected.
Do You Need to Fast?
No fasting is required for this test. The sample used is a tissue block from a previous biopsy or surgery, so no new dietary restrictions apply. Always follow specific instructions provided by your doctor.
Practical Tips Before Your Test
Keep the following in mind before proceeding with the Solidseq HRR gene panel [15 genes] test:
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test
- Carry all relevant medical records, including pathology reports from prior biopsies or surgeries
- Inform your doctor about any genetic tests you have previously undergone
- Discuss your cancer treatment history with the requesting doctor before sample submission
- Genetic counselling before testing is strongly recommended to understand what the results may mean for you and your family
Step-by-Step Procedure
- Your treating doctor or oncologist reviews imaging scans to identify the best biopsy site and confirms you are suitable for the procedure.
- Local anaesthesia is applied at the biopsy site. For deeper tumours, light sedation may also be provided.
- A needle biopsy is performed under image guidance, collecting several tissue cores from the tumour.
- The tissue cores are placed in a formalin-filled container and then embedded in paraffin wax to create the FFPE tissue block used for testing.
- The FFPE block is transported to the laboratory at ambient temperature (18°C to 28°C) for processing.
- DNA is extracted from the tissue and analysed using next-generation sequencing (NGS) to detect mutations across all 15 HRR genes.
- Molecular pathologists and geneticists review the sequencing data, classify any variants found, and prepare a detailed report, which is delivered within 30 days.
Factors That Can Affect Accuracy
- Low tumour content in the tissue block
- Poor DNA quality due to improper formalin fixation
- Presence of fat, mucin, bony tissue, or necrosis in the sample
- Inadequate sample volume or degradation during storage or transport
- Large DNA deletions (greater than 10 base pairs) and copy number variations may not be fully assessed by certain assay formats
Understanding Your Solidseq HRR Gene Panel [15 Genes] Test Results
Results from this test are reported as gene variant classifications rather than numerical values. The table below explains what each classification means:
| Result Category | Interpretation |
|---|---|
| Pathogenic or Likely Pathogenic | A harmful mutation has been detected; associated with increased cancer risk |
| Variant of Uncertain Significance (VUS) | A change was found, but its clinical impact is not yet clear |
| Benign or Likely Benign | The detected variant is not considered harmful |
| Negative (No Mutation Detected) | No pathogenic variants identified in the 15 tested genes |
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
How to Maintain Healthy Levels
While genetic results cannot be changed, there are practical steps that may support overall health:
- If a pathogenic variant is identified, follow the cancer screening schedule recommended by your doctor
- Share your result with close family members, as they may benefit from genetic testing as well
- Seek genetic counselling to understand your risk profile and available risk-reduction options
Lupin Diagnostics Solidseq HRR Gene Panel [15 Genes] Test Price
The Solidseq HRR gene panel [15 genes] test cost at Lupin Diagnostics starts at ₹24,000. This test requires a visit to a hospital or submission of an FFPE tissue block to the Lupin Diagnostics centre through your treating doctor; home collection is not available for this test. The table below shows indicative prices:
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 24000 |
| CHENNAI | 24000 |
| HYDERABAD | 24000 |
| KOLKATA | 24000 |
| NAVI MUMBAI | 24000 |
| PUNE | 24000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
The Solidseq HRR gene panel [15 genes] test online booking process is straightforward:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time, or coordinate with your doctor for tissue block dispatch to the laboratory.
- Receive your report via email or WhatsApp within the stipulated turnaround time of 30 days.
Frequently Asked Questions
The Solidseq HRR gene panel [15 genes] test is a genetic test that uses next-generation sequencing (NGS) to look for mutations in 15 genes involved in the homologous recombination repair pathway. These genes play a key role in keeping DNA stable, and mutations in them can raise the risk of certain cancers or influence treatment choices.
This test is recommended for people diagnosed with breast, ovarian, prostate, or pancreatic cancer, those with a strong family history of these cancers, individuals with early-onset cancer, or patients being assessed for PARP inhibitor therapy. Your oncologist or genetic counsellor will advise whether this test is appropriate for you.
The test requires an FFPE tissue block, which is a tumour tissue sample that was preserved in formalin and embedded in paraffin wax during a previous biopsy or surgical procedure. This block is typically available in the pathology archive of the hospital where your procedure was performed.
If a pathogenic mutation is found in genes such as BRCA1 or BRCA2, the patient may be eligible for PARP inhibitor therapies, which specifically target cancer cells with HRR defects. The results can also indicate sensitivity to platinum-based chemotherapy, helping doctors choose the most appropriate treatment plan.
At Lupin Diagnostics, the report is delivered within 30 days of the laboratory receiving an adequate sample. The test results are delivered directly via email or WhatsApp.
A positive result means that a pathogenic (harmful) mutation was found in one or more of the 15 HRR genes tested. This may indicate an increased risk of hereditary cancer or suggest that the tumour may respond well to specific treatments such as PARP inhibitors or platinum-based chemotherapy. Your oncologist will discuss the next steps.
Genetic counselling is strongly recommended before and after testing. A counsellor helps you understand what the test involves, what the results could mean for you personally, and what implications a positive result may have for your close relatives.
Solidseq HRR Gene Panel [15 Genes] Test: Booking, Price, and Results
