Solidseq Colorectal Cancer Panel [71 Genes] Test: Booking, Price, and Results
About Solidseq Colorectal Cancer Panel [71 Genes] Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Colorectal Cancer NGS Panel, 71-Gene Colorectal Cancer Sequencing Panel |
| Sample Type | FFPE Tissue Block |
| Fasting Required | No fasting required |
| Report Time | 30 days |
| Recommended For | Adults with confirmed or suspected colorectal cancer; males and females |
| Price | Starting at ₹36,000 |
What Is a Solidseq Colorectal Cancer Panel [71 Genes] Test?
The Solidseq colorectal cancer panel [71 genes] test is an advanced molecular test that uses Next-Generation Sequencing (NGS) technology to analyse 71 genes linked to colorectal cancer. It is performed on a formalin-fixed paraffin-embedded (FFPE) tissue block, which is a preserved tumour tissue sample obtained through a biopsy or surgery. Oncologists use this test to understand the genetic make-up of a tumour and guide treatment decisions. It is also known as the colorectal cancer NGS panel or the 71-gene colorectal cancer sequencing panel.
What Does a Solidseq Colorectal Cancer Panel [71 Genes] Test Measure?
This test screens all 71 genes in the panel for mutations, amplifications, and other changes that influence how colorectal cancer behaves and responds to treatment. The genes tested are listed below:
| Gene | Relevance |
|---|---|
| KRAS | Mutations predict resistance to anti-EGFR therapies; present in 35 to 45% of colorectal cancers |
| NRAS | RAS family gene; mutations also indicate poor response to anti-EGFR treatment |
| BRAF | Mutated in approximately 8 to 15% of colorectal cancers; affects prognosis and therapy choices |
| APC | Tumour suppressor gene; loss of function contributes to tumour progression |
| TP53 | Tumour suppressor gene; mutated in approximately 40 to 50% of colorectal cancers |
| PIK3CA, PIK3R1 | Cell signalling genes; mutations may affect therapy response and prognosis |
| MLH1, MSH2, MSH3, MSH6, PMS1, PMS2 | Mismatch repair genes; mutations associated with Lynch syndrome and immunotherapy eligibility |
| BRCA1, BRCA2, PALB2, CHEK2, ATM | DNA repair genes linked to hereditary cancer risk |
| ERBB2 (HER2), EGFR, MET, RET, KIT | Growth factor receptor genes; potential targets for treatment |
| PTEN, SMAD2, SMAD4, CTNNB1, AXIN2 | Tumour suppressor and signalling pathway genes |
| STK11, BMPR1A, FLCN, ENG, EP300 | Additional cancer-related regulatory genes |
| ACVR1B, AKT1, ATP6V0D2, BAX, BLM | Apoptosis, signalling, and DNA damage response genes |
| BUB1B, CASP8, CDC27, CDK4, CDKN2A | Cell cycle control genes |
| CTNNA1, DCC, DMD, EPCAM, FBXW7 | Tumour suppressor and cell adhesion genes |
| FGFR3, FZD3, GALNT12, GPC6, GREM1 | Signalling and growth regulation genes |
| MAP2K4, MAP7, MIER3, MLH3, MUTYH | DNA repair and signalling genes |
| MYO1B, POLD1, POLE, PTPN12, RPS20 | DNA replication fidelity and tumour suppressor genes |
| SCG5, SLC9A9, SRC, TCERG1, TCF7L2 | Additional genes involved in cancer biology |
| TGFBR2 | TGF-beta signalling; mutations associated with microsatellite unstable tumours |
Why Is a Solidseq Colorectal Cancer Panel [71 Genes] Test Done?
This test is ordered when a doctor needs detailed genetic information about a colorectal tumour to plan or adjust treatment. It goes well beyond standard diagnostic tests by revealing the specific mutations driving the cancer.
Common Symptoms That May Require This Test
Doctors may recommend this test after a colorectal cancer diagnosis is confirmed. The symptoms that typically lead to investigation and eventual genetic testing include the following:
- Persistent change in bowel habits, such as diarrhoea or constipation
- Rectal bleeding or blood in the stool
- Narrow or ribbon-like stools
- Ongoing abdominal discomfort, cramping, or pain
- A feeling that the bowel has not emptied completely
- Unexplained fatigue or weakness
- Unintentional weight loss
Conditions This Test Can Help Detect
This panel provides information relevant to several clinical situations. Below are the key conditions and scenarios it addresses:
- Metastatic colorectal cancer requiring targeted therapy planning
- RAS (KRAS and NRAS) and BRAF mutation status for anti-EGFR therapy eligibility
- Microsatellite instability (MSI) status to assess suitability for immunotherapy
- Lynch syndrome and other hereditary colorectal cancer predispositions via mismatch repair gene analysis
- Molecular classification of colorectal cancer for prognosis and clinical trial eligibility
Solidseq Colorectal Cancer Panel [71 Genes] Test for Chronic Disease Monitoring
For patients already on treatment for colorectal cancer, this test provides valuable genetic data that helps oncologists track how the tumour is responding. Repeated testing can detect new resistance mutations that emerge during therapy. This supports timely changes to the treatment plan based on the evolving genetic profile of the tumour.
How to Prepare and What to Expect
Preparation for this test is straightforward, but providing complete clinical information is essential for accurate result interpretation.
Do You Need to Fast?
No fasting is required before this test. The sample used is a preserved tissue block, not a blood sample drawn under fasting conditions. Always follow specific instructions provided by your doctor.
Practical Tips Before Your Test
The following steps will help ensure the test proceeds without delays:
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test
- Inform your oncologist about all current medications, including chemotherapy or targeted therapies in progress
- Confirm that your FFPE tissue block from a recent biopsy or surgery is available and will be submitted to the lab
- Let your doctor know if your tissue sample is from a procedure done several years ago, as sample age can affect quality
Step-by-Step Procedure
The tumour tissue sample for this test is collected via a colonoscopy biopsy. Here is how the procedure typically works:
- You will be asked to lie on your side on an examination table. The doctor will gently insert a thin, flexible instrument called a colonoscope through the anus to examine the inner lining of the colon and rectum.
- Before or during the procedure, sedation is administered through a vein in your hand or arm.
- Once the doctor locates the area of concern, a small instrument called biopsy forceps is passed through the colonoscope. This is used to pinch away a tiny piece of tissue from the bowel lining.
- The tissue sample is carefully collected and labelled. In some cases, tissue may already be available from a prior surgical resection.
- The collected tissue is sent to the pathology laboratory for analysis.
Factors That Can Affect Accuracy
Certain factors may influence the quality of results. These include the following:
- Age and quality of the FFPE tissue block
- Low tumour cell content in the sample
- Prior chemotherapy, which can alter the genetic profile of tumour cells
- Inadequate or incomplete clinical history submitted with the sample
- Tumour heterogeneity, where different parts of the tumour carry different mutations
Understanding Your Solidseq Colorectal Cancer Panel [71 Genes] Test Results
Results from this test are qualitative. They describe the genetic variants found in the tumour rather than providing numerical values. Your oncologist or a molecular pathologist will explain what each finding means for your care. The table below summarises the key findings:
| Result Type | Interpretation |
|---|---|
| No pathogenic variant detected | No clinically significant mutations were found in the 71 genes tested |
| Pathogenic or likely pathogenic variant | A mutation known or strongly suspected to influence cancer behaviour or treatment response was identified |
| Variant of uncertain significance (VUS) | A genetic change was found, but its clinical impact is not yet established |
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Low tumour DNA content in the tissue sample may reduce the test's ability to detect certain mutations, leading to a false-negative result. The assay may not detect molecular alterations present at very low levels, typically below approximately 5%. If you have recently received chemotherapy, your oncologist will consider this when interpreting the results, as treatment can affect the genetic material available for analysis.
How to Maintain Healthy Levels
This test identifies tumour mutations rather than measuring a value that can be improved through lifestyle changes. The following general steps support your overall care:
- Attend all scheduled follow-up appointments with your oncologist to review results and adjust your treatment plan as needed.
- Maintain a balanced diet and stay physically active as advised by your care team to support overall health during treatment.
- Discuss your results, including any variants of uncertain significance, openly with your doctor so that all findings are considered in your care.
Lupin Diagnostics Solidseq Colorectal Cancer Panel [71 Genes] Test Price
The Solidseq colorectal cancer panel [71 genes] test cost starts at ₹36,000. This test requires a visit to a Lupin Diagnostics centre or submission of an FFPE tissue block through your treating hospital; home collection is not available for this test. The table shows indicative prices:
| City | Approximate Price (₹) |
|---|---|
| Mumbai | 36000 |
| Pune | 36000 |
| Bangalore | 36000 |
| Chennai | 36000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Follow these steps for the Solidseq colorectal cancer panel [71 genes] test online booking:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time, or arrange for your FFPE tissue block to be submitted through your treating hospital or oncologist.
- Receive your report via email or WhatsApp within 30 days of sample receipt.
Frequently Asked Questions
The Solidseq colorectal cancer panel [71 genes] test is a molecular diagnostic test that uses NGS technology to analyse 71 genes in a tumour tissue sample. It helps oncologists understand the genetic changes driving the cancer and select the most appropriate treatment. The sample used is an FFPE tissue block from a biopsy or surgical resection.
This test is recommended for patients with confirmed colorectal cancer, particularly those with advanced or metastatic disease. It is also useful when a doctor needs to determine eligibility for targeted therapies, immunotherapy, or clinical trials. Your oncologist will advise whether this panel is appropriate for your situation.
A detailed clinical history is required along with the tissue sample. This should include your symptoms, diagnosis details, previous treatment history, and any relevant family history of cancer. Submitting complete information helps the laboratory deliver an accurate and clinically useful report.
At Lupin Diagnostics, the Solidseq colorectal cancer panel [71 genes] test has a turnaround time of 30 days from the date the laboratory receives your tissue sample. The report is delivered directly via email or WhatsApp.
The panel includes mismatch repair genes such as MLH1, MSH2, MSH6, and PMS2. Mutations in these genes are associated with Lynch syndrome, the most common cause of inherited colorectal cancer. If the test identifies changes in these genes, your doctor may recommend additional germline testing to confirm whether the finding is hereditary.
No. The Solidseq colorectal cancer panel [71 genes] test uses a solid tumour tissue block (FFPE) as its sample, whereas the Liquidseq panel uses a blood sample to analyse circulating tumour DNA. Both panels cover 71 genes, but the sample type and collection process differ. Your oncologist will advise which variant is suitable based on tissue availability and your clinical needs.
Solidseq Colorectal Cancer Panel [71 Genes] Test: Booking, Price, and Results
