PGT SR - 9 Embryos Test: Booking, Price, and Results
About PGT SR - 9 Embryos Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | PGT-SR, Preimplantation Genetic Testing for Structural Rearrangements (9 embryos), PGD for Structural Rearrangements |
| Sample Type | Embryo biopsy (trophectoderm cells from a day-5 or day-6 blastocyst-stage embryo, collected within an IVF laboratory) |
| Fasting Required | Not applicable. This test involves an embryo biopsy, not a blood or urine sample from the patient. |
| Report Time | 18 days |
| Recommended For | Couples where one or both partners carry a known balanced chromosomal structural rearrangement and are undergoing IVF |
| Price | Starting at ₹1,29,500 |
What Is a PGT SR - 9 Embryos Test?
The PGT SR - 9 Embryos Test is a specialised genetic screening test performed on embryos created through IVF (in vitro fertilisation). PGT-SR stands for Preimplantation Genetic Testing for Structural Rearrangements. It screens the chromosomes of up to nine embryos before any are transferred to the uterus.
The test is recommended for couples where one or both partners carry a balanced chromosomal structural rearrangement, such as a translocation or inversion. A small cluster of cells is carefully removed from each embryo and sent to a genetics laboratory for analysis using NGS (Next-Generation Sequencing) technology.
What Does a PGT SR - 9 Embryos Test Measure?
This test examines the chromosomal makeup of each biopsied embryo. The following aspects are assessed.
| What Is Analysed | What It Means |
|---|---|
| Chromosomal structural imbalances | Detects extra or missing chromosomal segments arising from the parent's known structural rearrangement |
| Numerical chromosome abnormalities (aneuploidies) | Identifies embryos with too many or too few whole chromosomes (e.g., trisomy or monosomy) |
| Segmental gains or losses | Checks for smaller chromosomal gains or losses that could affect embryo viability |
This test detects chromosomal imbalances but does not screen for single-gene disorders or multifactorial conditions. The ability to identify balanced chromosomal rearrangements depends on the laboratory method used.
Why Is a PGT SR - 9 Embryos Test Done?
This test is ordered in specific clinical situations, usually within the context of an IVF programme. It is not triggered by physical symptoms in the conventional sense.
Common Symptoms That May Require This Test
The following situations commonly lead a fertility specialist to recommend the PGT SR - 9 Embryos Test.
- Recurrent pregnancy loss (repeated miscarriages)
- A confirmed balanced translocation or inversion identified on one or both partners' karyotype
- Recurrent implantation failure during previous IVF cycles
- A previous pregnancy or child affected by an unbalanced chromosomal rearrangement
- Unexplained infertility where chromosomal structural issues are suspected
- History of IVF cycles producing many embryos that did not result in a successful pregnancy
Conditions This Test Can Help Detect
The PGT SR test helps identify embryos affected by the following conditions before transfer.
- Unbalanced chromosomal rearrangements (extra or missing chromosome segments)
- Whole-chromosome aneuploidies such as trisomy or monosomy
- Chromosomal mosaicism (a mix of normal and abnormal cells within the embryo)
- Segmental copy number changes resulting from parental reciprocal or Robertsonian translocations
- Chromosomal imbalances from parental inversions or complex rearrangements
How to Prepare and What to Expect
Since this test is performed on embryos in an IVF laboratory, the preparation process is different from a standard blood or urine test. Here is what couples need to know before proceeding.
Do You Need to Fast?
Fasting is not required for this test. The sample is an embryo biopsy collected in an IVF laboratory, not a blood draw from the patient.
Practical Tips Before Your Test
Before the PGT SR - 9 Embryos Test, couples should take care of the following steps.
- Ensure both partners have completed karyotyping (a chromosomal blood test), as parental reports confirming the structural rearrangement are required for the analysis
- Bring a detailed clinical history, including symptoms, previous test results, biopsy worksheets, and family history, as this is required for the test
- Submit the duly filled Test Request Form (TRF) and signed consent form as requested by the laboratory
- Attend genetic counselling before and after the test to understand the implications of possible results
- Confirm with your IVF centre that embryos will be biopsied on day 5 or day 6 (blastocyst stage), as this is the preferred sample collection stage
- Coordinate between your IVF centre and the genetics laboratory in advance so the testing process is ready when embryos reach the correct stage
Step-by-Step Procedure
- Eggs are retrieved from the female partner and fertilised in the laboratory using the male partner's sperm to create embryos.
- The embryos are cultured for approximately five to six days until they reach the blastocyst stage.
- A trained embryologist removes five to six trophectoderm cells from each embryo using laser-assisted micromanipulation. Up to nine embryos are biopsied under this test package.
- The biopsied cells are placed in a PGT collection kit and transported on dry ice at -20°C to the genetics laboratory.
- In the laboratory, the cells undergo whole genome amplification and are analysed using NGS technology to detect chromosomal copy number changes and structural imbalances.
- A detailed PGT report is prepared and shared with the treating fertility specialist.
Factors That Can Affect Accuracy
Several factors can influence the reliability of the PGT SR - 9 Embryos Test result.
- Embryo quality and developmental stage at the time of biopsy
- Presence of chromosomal mosaicism (a mix of normal and abnormal cells) within the embryo
- Contamination from cumulus cells attached to the zona pellucida, which can introduce maternal DNA
- The experience of the embryologist performing the trophectoderm biopsy
- Laboratory quality control and the sequencing platform used for analysis
Understanding Your PGT SR - 9 Embryos Test Results
Each embryo receives a categorical classification. A fertility specialist and genetic counsellor will review these classifications together with the couple's specific chromosomal rearrangement before any transfer decision is made.
| Result Category | Meaning | Suitability for Transfer |
|---|---|---|
| Euploid / Normal | Normal chromosomal complement with no detectable unbalanced rearrangement | Generally suitable for transfer |
| Balanced Carrier | Carries the parental balanced rearrangement with no net gain or loss of genetic material | Generally suitable for transfer; genetic counselling may be recommended |
| Unbalanced | Extra or missing chromosomal material resulting from the parental rearrangement | Generally not selected for transfer |
| Aneuploid | Extra or missing whole chromosome(s), such as trisomy or monosomy | Generally not selected for transfer |
| Mosaic | Evidence of both normal and abnormal chromosomal cell populations | Reviewed on a case-by-case basis with the fertility specialist and genetic counsellor |
| Inconclusive / No Result | No reliable result obtained due to insufficient DNA or technical limitations | Repeat testing or re-biopsy may be considered |
Disclaimer: These categories are general guidelines. Your fertility specialist and genetic counsellor will interpret your results in the context of your specific chromosomal rearrangement, reproductive history, and overall IVF cycle. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain factors may affect how results are interpreted.
- Because the trophectoderm sample contains multiple cells, some embryos may show a mix of normal and abnormal cells. This can yield inconclusive or mosaic results that require careful discussion with your clinician before any decision is made.
- Residual maternal cells around the embryo can introduce extra DNA into the sample, potentially affecting the accuracy of the analysis.
- Slow-growing or lower-quality blastocysts may yield fewer trophectoderm cells, which can reduce the reliability of the result.
How to Maintain Healthy Levels
While embryo chromosomal outcomes cannot be directly controlled, the following general steps can support the best possible IVF outcomes.
- Attend all recommended genetic counselling sessions before and after results are available to fully understand your rearrangement and its implications.
- Follow your fertility specialist's medication and lifestyle guidance closely throughout the IVF cycle to support egg and embryo quality.
- Be prepared that the proportion of embryos suitable for transfer may be lower in a PGT-SR cycle compared to standard IVF, and discuss expectations with your care team in advance.
Lupin Diagnostics PGT SR - 9 Embryos Test Price
The PGT SR - 9 Embryos Test cost at Lupin Diagnostics starts at ₹1,29,500. This test requires a visit to a Lupin Diagnostics centre or a coordinated arrangement through your IVF laboratory. Home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 129500 |
| CHENNAI | 129500 |
| HYDERABAD | 129500 |
| KOLKATA | 129500 |
| NAVI MUMBAI | 129500 |
| PUNE | 129500 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time, or coordinate sample dispatch through your IVF laboratory as advised.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
PGT-SR is designed specifically for couples who carry a known chromosomal structural rearrangement, such as a balanced translocation or inversion. It screens embryos for imbalances arising from that specific parental rearrangement and also detects whole-chromosome abnormalities. PGT-A, on the other hand, only checks for whole-chromosome number changes and is used when no structural rearrangement has been identified in either partner.
Laboratories offer PGT testing in tiered packages based on the number of embryos to be tested. The PGT SR - 9 Embryos package allows up to nine blastocyst-stage embryos to be biopsied and analysed within a single testing cycle. Couples whose IVF cycle produces more than nine embryos may need an additional package for the remaining embryos.
Current guidance from organisations such as ESHRE and ASRM indicates no clear evidence of increased risk to the embryo from trophectoderm biopsy. The cells removed are from the outer layer that forms the placenta, leaving the inner cell mass (which develops into the baby) untouched.
Results are available within approximately 18 days of the embryo biopsy. During this time, the biopsied embryos are kept frozen (vitrified) in the IVF laboratory.
No test can guarantee a successful pregnancy or a healthy baby. The PGT SR test significantly improves the chances of selecting a chromosomally suitable embryo for transfer and can reduce miscarriage risk.
This test is most relevant for couples where one or both partners carry a balanced chromosomal structural rearrangement, including reciprocal translocations, Robertsonian translocations, inversions, or complex rearrangements. It is particularly useful for those who have experienced recurrent miscarriages or failed IVF cycles linked to a chromosomal cause.
No. The PGT SR - 9 Embryos Test procedure requires an embryo biopsy performed by a trained embryologist within a specialised IVF laboratory.
PGT SR - 9 Embryos Test: Booking, Price, and Results
