PGT SR - 8 Embryos Test: Booking, Price, and Results
About PGT SR - 8 Embryos Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | PGT-SR, Preimplantation Genetic Testing for Structural Rearrangements (8 Embryos), PGD for translocations, PGT for chromosomal rearrangements |
| Sample Type | Trophectoderm biopsy cells (5 to 6 cells from the outer layer of each IVF embryo at the blastocyst stage) |
| Fasting Required | No. This test is performed on embryo biopsy samples, not on a blood or urine sample from the patient. |
| Report Time | 18 days |
| Recommended For | Couples undergoing IVF where one or both partners carry a known balanced chromosomal rearrangement (translocation or inversion) |
| Price | Starting at ₹1,15,000 |
What Is a PGT SR - 8 Embryos Test?
The PGT SR - 8 Embryos Test is a genetic analysis performed on embryos created through in vitro fertilisation (IVF). PGT-SR stands for Preimplantation Genetic Testing for Structural Rearrangements. It checks up to 8 embryos in a single IVF cycle for chromosomal imbalances caused by a known structural rearrangement in one or both parents.
The test uses Next Generation Sequencing (NGS), a method that reads the genetic material in detail, on cells biopsied from each embryo before it is transferred to the uterus. It is also known as PGD for translocations or PGT for chromosomal rearrangements.
What Does a PGT SR - 8 Embryos Test Measure?
The PGT SR - 8 Embryos Test procedure analyses embryo cells for four types of chromosomal findings. The table below outlines what is assessed.
| What Is Analysed | Plain Language Explanation |
|---|---|
| Unbalanced structural rearrangements | Extra or missing chromosomal segments arising from a parental translocation or inversion |
| Aneuploidy | An abnormal total number of chromosomes in the embryo |
| Mosaicism | A mix of chromosomally normal and abnormal cells within the same embryo |
| Segmental gains or losses | Extra or missing portions of individual chromosomes |
Disclaimer: This test detects chromosomal imbalances but does not screen for single-gene disorders. The ability to identify balanced chromosomal rearrangements depends on the testing method used by the laboratory.
Why Is a PGT SR - 8 Embryos Test Done?
This test is ordered by fertility specialists for couples with a specific genetic reason that may affect IVF outcomes. Below are the common reasons it is prescribed.
Common Symptoms That May Require This Test
The following are common clinical situations that lead a doctor to recommend PGT-SR testing:
- Recurrent pregnancy loss or repeated miscarriages
- Repeated IVF implantation failures despite good-quality embryos
- A known balanced chromosomal translocation in one or both partners
- A chromosomal inversion was identified in a partner
- A previous pregnancy affected by chromosomal abnormalities
- Infertility linked to chromosomal factors
- A family history of chromosomal structural rearrangements
Conditions This Test Can Help Detect
The PGT SR - 8 Embryos Test helps identify embryos affected by the following chromosomal situations:
- Unbalanced reciprocal translocations (sections of two chromosomes have swapped in a way that causes gain or loss of material)
- Unbalanced Robertsonian translocations (two specific chromosomes have joined together, creating an imbalance)
- Chromosomal inversions (a segment of a chromosome is reversed)
- Ring chromosomes and other complex chromosomal rearrangements
- Whole-chromosome aneuploidies such as trisomy (an extra chromosome) or monosomy (a missing chromosome)
How to Prepare and What to Expect
The PGT SR - 8 Embryos Test is not a standard blood or urine test. Preparation involves steps taken at the IVF clinic rather than by the patient at home.
Do You Need to Fast?
No fasting is required. The sample is an embryo biopsy performed in the IVF laboratory, not a blood or urine sample from the patient.
Practical Tips Before Your Test
The following steps will help ensure the test can proceed smoothly:
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test
- Ensure both partners have a completed karyotype (a chromosome analysis from a blood test) before planning the cycle, as parental karyotype reports are mandatory
- Carry a duly filled Test Request Form (TRF) and biopsy worksheet to the laboratory, along with a signed consent form
- Attend genetic counselling before the cycle to understand the possible outcomes and limitations of the test
Step-by-Step Procedure
- Eggs are retrieved and fertilised in the IVF laboratory, typically using ICSI.
- Embryos are cultured in the lab for approximately five to six days until they reach the blastocyst stage.
- A trophectoderm biopsy is performed, removing 5 to 6 cells from the outer layer of each blastocyst. This outer layer forms the placenta; the inner part that becomes the baby is left undisturbed.
- The biopsied embryos are vitrified (rapidly frozen and stored) while the samples are sent to the Lupin Diagnostics genetics laboratory for analysis.
- The biopsy samples are analysed using NGS at the laboratory, and results are prepared within 18 days.
- Once results are available, the fertility specialist reviews each embryo's genetic status and advises on which embryos are suitable for frozen embryo transfer.
Factors That Can Affect Accuracy
The following factors may influence the reliability of the test result:
- The quality and developmental stage of the embryo at the time of biopsy
- The number of cells successfully obtained during the trophectoderm biopsy
- Mosaicism within the embryo, where some cells differ genetically from others
- The efficiency of whole genome amplification (the process of multiplying the small amount of DNA from the biopsy for analysis)
- Laboratory expertise and the NGS platform used
Understanding Your PGT SR - 8 Embryos Test Results
Results for each embryo are reported as one of five categorical outcomes rather than numerical values. A fertility specialist and genetic counsellor should review all results in the context of the couple's karyotypes and clinical history.
| Result Category | Meaning | Transfer Recommendation |
|---|---|---|
| Euploid / Balanced | Normal chromosome number; no unbalanced rearrangement detected | Suitable for transfer |
| Aneuploid | An abnormal number of whole chromosomes | Not recommended for transfer |
| Unbalanced | Extra or missing chromosomal segments from the parental rearrangement | Not recommended for transfer |
| Mosaic | Mix of normal and abnormal cell lines (20% or more abnormal) | May be considered after genetic counselling |
| No result | Laboratory unable to generate a valid analysis from the biopsy | Re-biopsy or untested transfer may be considered |
Disclaimer: These categories are general guidelines. Your doctor and genetic counsellor will interpret your results based on your specific chromosomal rearrangement, clinical history, and reproductive goals. Always consult a qualified healthcare professional for personalised medical advice.
How to Maintain Healthy Levels
While chromosomal outcomes cannot be altered through lifestyle, the following general wellness steps support IVF cycle success:
- Eat a balanced diet rich in vegetables, whole grains, and lean protein throughout the IVF process.
- Manage stress through rest and light physical activity, as advised by your fertility team.
- Ensure both partners have up-to-date karyotyping completed before the cycle begins, so the laboratory has all necessary information.
Lupin Diagnostics PGT SR - 8 Embryos Test Price
The PGT SR - 8 Embryos Test cost at Lupin Diagnostics starts at ₹1,15,000. This test requires a visit to a Lupin Diagnostics centre; home collection is not available for this test. The city-wise price breakdown is provided below for reference.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 115000 |
| CHENNAI | 115000 |
| HYDERABAD | 115000 |
| KOLKATA | 115000 |
| NAVI MUMBAI | 115000 |
| PUNE | 115000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time for sample collection coordination with your IVF laboratory.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
PGT-SR is designed specifically for couples where one or both partners carry a known chromosomal rearrangement, such as a translocation or inversion. It checks whether embryos have inherited an unbalanced form of that rearrangement. PGT-A, by contrast, screens embryos for general aneuploidy in couples without a known structural rearrangement.
IVF cycles can produce varying numbers of blastocysts. An 8-embryo package allows genetic analysis of up to 8 embryos from a single cycle, which may be more cost-effective than per-embryo pricing. The actual number tested may be fewer if not all embryos reach the blastocyst stage.
No. The sample is a trophectoderm biopsy taken from IVF embryos in a specialised embryology laboratory. This procedure cannot be performed at home and requires trained embryologists and laboratory equipment.
Results are available within 18 days of the embryo biopsy. Embryos are vitrified (frozen) while results are processed, and a frozen embryo transfer is scheduled once suitable embryos are identified.
No. PGT-SR significantly reduces the risk of transferring chromosomally unbalanced embryos but does not screen for all possible genetic conditions. There is a general background risk of birth defects of approximately 4 to 6% for any baby born following IVF. Prenatal testing, such as amniocentesis or chorionic villus sampling (CVS), is still recommended during pregnancy.
If no euploid or balanced embryos are identified, the couple may discuss options with their fertility specialist. These include undertaking another IVF cycle to generate new embryos or considering mosaic embryos with appropriate genetic counselling. Research indicates a live birth rate of approximately 66.6% per transfer of balanced or normal embryos.
Yes. Parental karyotyping, a chromosome analysis performed from a blood sample, is required before PGT-SR can be planned. It helps the laboratory identify the specific chromosomal regions to evaluate in the embryos and is a mandatory requirement for this test.
PGT SR - 8 Embryos Test: Booking, Price, and Results
