PGT SR - 7 Embryos Test: Booking, Price, and Results
About PGT SR - 7 Embryos Test
| Field | Value |
|---|---|
| Also Known As | PGT-SR, Preimplantation Genetic Testing for Structural Rearrangements (7 embryos), PGD for chromosomal rearrangements, PGT for translocations and inversions |
| Sample Type | Trophectoderm biopsy (cells taken from the outer layer of each IVF embryo at blastocyst stage, day 5 or 6 of development) |
| Fasting Required | No, this test is performed on embryonic cells, not on the patient directly |
| Report Time | 18 days |
| Recommended For | Couples undergoing IVF where one or both partners carry a known balanced chromosomal structural rearrangement; all adult ages |
| Price | Starting at ₹1,00,000 |
What Is a PGT SR - 7 Embryos Test?
The PGT SR - 7 Embryos Test is a specialised genetic test performed on IVF embryos before they are transferred to the uterus. PGT-SR stands for Preimplantation Genetic Testing for Structural Rearrangements. It examines the chromosomal structure of up to seven embryos in a single IVF cycle to identify those with the best chance of a healthy pregnancy. This test is recommended for couples where one or both partners carry a chromosomal structural change, such as a translocation or inversion.
What Does a PGT SR - 7 Embryos Test Measure?
Rather than producing numerical values, the PGT SR - 7 Embryos Test procedure classifies each embryo based on its chromosomal profile. Using next-generation sequencing (NGS), the test analyses all 23 chromosome pairs in each biopsy sample. The test evaluates the following in each embryo:
| What Is Evaluated | What It Means |
|---|---|
| Unbalanced Structural Rearrangements | Extra or missing chromosomal material resulting from a parental structural rearrangement, such as a translocation or inversion |
| Numerical Chromosome Abnormalities (Aneuploidies) | Extra or missing whole chromosomes, such as trisomies or monosomies |
| Segmental Gains or Losses | Duplications or deletions of smaller chromosomal regions that may affect embryo viability or development |
| Mosaicism | A mixture of chromosomally normal and abnormal cell populations within the same embryo |
Why Is a PGT SR - 7 Embryos Test Done?
This test is prescribed in specific clinical situations related to IVF and known chromosomal changes in one or both partners.
Common Symptoms That May Require This Test
The following situations commonly lead a fertility specialist to recommend PGT-SR:
- Known balanced translocation or chromosomal inversion in one or both partners
- Recurrent miscarriages (two or more pregnancy losses)
- Repeated IVF implantation failure with no clear cause
- A previous pregnancy affected by a chromosomal structural abnormality
- Family history of a chromosomal structural rearrangement
- Ring chromosomes or other rare structural abnormalities identified in a parent
Conditions This Test Can Help Detect
PGT-SR helps identify embryos affected by the following chromosomal situations:
- Reciprocal translocations (segments swapped between two different chromosomes)
- Robertsonian translocations (two specific chromosomes joining together)
- Chromosomal inversions (a segment flipped within a chromosome)
- Complex chromosomal rearrangements involving multiple chromosomes
- Whole-chromosome aneuploidies across all 23 chromosome pairs
How to Prepare and What to Expect
The PGT SR - 7 Embryos Test does not require any preparation, as the sample is collected from embryos rather than from the patient's body. However, there are important steps to complete before the IVF cycle begins.
Do You Need to Fast?
No fasting is required. This test is performed on embryo cells, so food and drink restrictions do not apply.
Practical Tips Before Your Test
Before starting the IVF cycle for PGT-SR, keep the following points in mind:
- Ensure both partners' karyotype (chromosome map) results are available, as parental reports for structural variations are mandatory for this test
- Carry a detailed clinical history, including symptoms, previous test results, and family history, along with a duly filled test request form, biopsy worksheet, and signed consent form, as these are required
- Attend genetic counselling before the IVF cycle, so both partners fully understand the scope and limitations of the test
- The recommended fertilisation method for PGT-SR cycles is ICSI (intracytoplasmic sperm injection, where a single sperm is injected directly into each egg) to prevent DNA contamination
- Plan for a frozen embryo transfer cycle, as embryos are vitrified (rapidly frozen) while results are being processed
Step-by-Step Procedure
- Eggs are retrieved from the female partner and fertilised with sperm in the laboratory, using ICSI as the preferred method.
- The fertilised embryos are cultured in the lab for 5 to 6 days until they reach the blastocyst stage, developing an outer cell layer called the trophectoderm.
- A trained embryologist removes 5 to 6 cells from the outer layer of each blastocyst using micro-manipulation tools. The inner cell mass, the part that develops into the baby, is left untouched.
- All biopsied embryos are rapidly frozen and stored safely while genetic analysis is carried out.
- The biopsied cells undergo whole genome amplification (a technique to increase the tiny amount of DNA available), followed by next-generation sequencing. All 23 chromosome pairs are examined for each embryo.
- A detailed report classifying each embryo is generated and shared with the treating fertility specialist, who discusses the results and next steps with the couple.
Factors That Can Affect Accuracy
Several factors can influence the reliability of PGT-SR results:
- Quality and number of trophectoderm cells collected during biopsy
- Mosaicism within an embryo (mixed cell lines may give intermediate results)
- Correct labelling and careful handling of each embryo's biopsy sample
- Use of ICSI to avoid contamination from extra paternal DNA
- Laboratory expertise in whole genome amplification and NGS analysis
Understanding Your PGT SR - 7 Embryos Test Results
Results from the PGT SR - 7 Embryos Test are reported qualitatively for each embryo and should always be reviewed with a fertility specialist and a genetic counsellor.
| Classification | Meaning | Transfer Recommendation |
|---|---|---|
| Euploid or Balanced carrier | No unbalanced rearrangement; normal chromosome count | Suitable for transfer |
| Aneuploid or Unbalanced | Chromosomal imbalance detected | Not recommended for transfer |
| Mosaic | Mixed normal and abnormal cells | Case-by-case discussion with a specialist |
| No result or Inconclusive | Insufficient DNA or amplification failure | Re-biopsy may be considered |
Disclaimer: These classifications are general guidelines. Your doctor will interpret your results based on your specific chromosomal rearrangement, reproductive history, and overall IVF plan. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain situations can affect how results are interpreted:
- When an embryo contains two or more genetically different cell lines, the biopsy may not fully represent the rest of the embryo, leading to intermediate or uncertain results.
- Standard PGT-SR cannot distinguish between a truly normal embryo and a balanced carrier embryo (one that carries the rearrangement but has no gain or loss of chromosome material). This means some carrier embryos may appear normal in the report.
- PGT-SR does not detect uniparental disomy (when both copies of a chromosome come from one parent) and does not directly assess for all possible birth defects.
How to Maintain Healthy Levels
While PGT-SR itself does not have "levels" to maintain, the following general steps can support a positive IVF outcome:
- Choose an IVF centre with experienced embryologists and a proven record in PGT-SR cycles
- Attend pre-cycle genetic counselling to understand your specific rearrangement type and its expected impact on embryo results
- Follow all IVF preparation advice from your fertility specialist to maximise the number and quality of embryos available for testing
Lupin Diagnostics PGT SR - 7 Embryos Test Price
The PGT SR - 7 Embryos Test cost at Lupin Diagnostics starts at ₹1,00,000. This test requires a visit to a Lupin Diagnostics centre or an affiliated IVF laboratory. Home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 100000 |
| CHENNAI | 100000 |
| HYDERABAD | 100000 |
| KOLKATA | 100000 |
| NAVI MUMBAI | 100000 |
| PUNE | 100000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Booking your PGT SR - 7 Embryos Test online is straightforward:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time; the embryo biopsy will be coordinated through the affiliated IVF laboratory.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
PGT-SR is designed specifically for couples where one partner carries a known chromosomal structural change, such as a translocation or inversion. PGT-A screens embryos for chromosome number abnormalities only. PGT-SR does both: it screens for aneuploidies and also targets the specific structural rearrangement carried by the parent.
IVF cycles can produce different numbers of embryos depending on the individual. The 7-embryo package is a bundled pricing tier covering genetic testing for up to seven biopsied blastocysts in a single cycle. If fewer embryos reach the blastocyst stage, fewer will be tested.
The biopsy removes 5 to 6 cells from the outer layer of the embryo (trophectoderm). The inner part of the embryo, which develops into the baby, is left completely undisturbed. When performed by a skilled embryologist, the risk of harm to the embryo is considered very low.
Standard PGT-SR cannot identify balanced carrier embryos, because a balanced carrier has no gain or loss of chromosome material. This means a balanced carrier embryo may appear the same as a fully normal embryo in the report. Some advanced methods may help make this distinction, but these are not universally available.
Report delivery is approximately 18 days from the time the laboratory receives the biopsy samples. During this period, all embryos remain safely vitrified (frozen). Transfer takes place in a subsequent frozen embryo transfer cycle once results are ready.
No. This test requires a trophectoderm biopsy performed by a trained embryologist in a specialised IVF laboratory. It cannot be conducted at home.
No test can guarantee this outcome. PGT-SR significantly improves the chances of selecting a chromosomally suitable embryo for transfer, but it does not screen for all possible genetic conditions or birth defects.
PGT SR - 7 Embryos Test: Booking, Price, and Results
