PGT SR - 6 Embryos Test: Booking, Price, and Results
About PGT SR - 6 Embryos Test
| Field | Value |
|---|---|
| Also Known As | PGT-SR, Preimplantation Genetic Testing for Structural Rearrangements, PGT for Structural Chromosomal Abnormalities |
| Sample Type | Embryo biopsy (trophectoderm cells from blastocyst-stage IVF embryos) |
| Fasting Required | Not applicable (test is performed on embryo cells, not on the patient) |
| Report Time | 18 days |
| Recommended For | Couples where one or both partners carry a balanced chromosomal rearrangement, such as a translocation or inversion |
| Price | Starting at ₹86,500 |
What Is a PGT SR - 6 Embryos Test?
The PGT SR - 6 Embryos Test is a specialised genetic test performed on embryos created through IVF (in vitro fertilisation). It screens up to six embryos for chromosomal imbalances caused by a structural rearrangement carried by one or both parents. The test is also known as PGT-SR, short for Preimplantation Genetic Testing for Structural Rearrangements. A small number of cells are taken from each embryo and analysed using NGS (next-generation sequencing) before any embryo is transferred to the uterus.
What Does a PGT SR - 6 Embryos Test Measure?
The PGT-SR test analyses the chromosomal content of each biopsied embryo. Here is what it looks for:
| What Is Assessed | Why It Matters |
|---|---|
| Unbalanced Chromosomal Rearrangements | Detects embryos with extra or missing chromosomal material resulting from a parental structural rearrangement, such as a translocation or inversion |
| Numerical Chromosome Abnormalities (Aneuploidies) | Identifies embryos with extra or missing whole chromosomes |
| Euploid or Balanced Status | Identifies embryos with no detectable chromosomal imbalance, which are generally preferred for transfer consideration |
Why Is a PGT SR - 6 Embryos Test Done?
The PGT SR - 6 Embryos Test is recommended when there is a known chromosomal structural rearrangement in the family. It helps identify embryos most likely to lead to a healthy pregnancy.
Common Symptoms That May Require This Test
Doctors typically recommend this test based on reproductive history rather than physical symptoms. The following histories are common indications:
- Recurrent miscarriages with no clear cause identified
- A confirmed diagnosis of a balanced chromosomal translocation or inversion in either partner
- Multiple failed IVF implantation attempts
- A previous pregnancy affected by chromosomal abnormalities
- A family history of chromosomal structural rearrangements
- Offspring born with developmental delay, intellectual disability, or birth defects linked to chromosomal causes
Conditions This Test Can Help Detect
The PGT SR - 6 Embryos Test procedure helps identify embryos affected by the following:
- Reciprocal translocations (where segments of two different chromosomes swap positions)
- Robertsonian translocations (where two chromosomes join together)
- Chromosomal inversions (where a segment of a chromosome is reversed)
- Complex chromosomal rearrangements involving multiple chromosomes
- De novo aneuploidies (new chromosomal number errors arising independently of the parental rearrangement)
How to Prepare and What to Expect
The PGT SR - 6 Embryos Test is not a standard blood or urine test. Preparation involves completing an IVF cycle first. The following sections explain what to arrange before and during the process.
Do You Need to Fast?
Fasting is not required. The test is performed on embryo biopsy cells, not on a blood or urine sample from the patient.
Practical Tips Before Your Test
There are several important steps to complete before your embryo biopsy samples are sent for analysis:
- Bring a detailed clinical history, including your symptoms, previous pregnancy losses, past test results, and family history, as this is required for the test
- Carry the duly filled Test Request Form (TRF), biopsy worksheet, and signed consent form
- Ensure parental karyotyping (chromosome analysis of both partners) has been completed before the IVF cycle begins
- Attend genetic counselling before starting the process to understand what the results can and cannot tell you
- Confirm that ICSI (intracytoplasmic sperm injection, where a single sperm is injected directly into the egg) is planned, as it is typically required for fertilisation in this context
- Use the designated PGT Collection Kit provided by the laboratory for sample transport
Step-by-Step Procedure
- The patient completes an IVF cycle as directed by their fertility specialist, including ovarian stimulation and egg retrieval.
- Retrieved eggs are fertilised in the laboratory using ICSI.
- Fertilised embryos are cultured until they reach the blastocyst stage, which occurs around day 5 or day 6 of development.
- A trained embryologist performs a biopsy, removing a small number of trophectoderm cells (the outer layer of the blastocyst) from each embryo using a fine needle and laser-assisted cutting.
- Each embryo is frozen within approximately one hour after biopsy to preserve its integrity for future transfer.
- The biopsied cells are placed in the PGT Collection Kit, stored on dry ice at -20°C, and dispatched to the Lupin Diagnostics laboratory for NGS-based analysis.
Factors That Can Affect Accuracy
Several factors may influence the accuracy or reliability of the PGT SR - 6 Embryos Test results:
- Low cell count in the biopsy sample due to poor embryo quality
- Mosaicism within the embryo (a mixture of chromosomally normal and abnormal cells)
- Very small chromosomal imbalances below the detection threshold of approximately 6 megabases
- Maternal cell contamination during the biopsy procedure
- Amplification failure due to insufficient DNA in the sample
Understanding Your PGT SR - 6 Embryos Test Results
Results are reported by the laboratory for each embryo individually. Your fertility specialist and genetic counsellor will review the findings with you before deciding which embryo is suitable for transfer.
| Result Category | What It Means |
|---|---|
| Euploid or Normal or Balanced | The embryo has the correct chromosome content and is suitable for transfer |
| Aneuploid or Unbalanced | The embryo carries extra or missing chromosome material; typically not recommended for transfer |
| Mosaic | A mixture of normal and abnormal cells is present; it requires a detailed clinical discussion before any transfer decision |
| No Result or Inconclusive | Insufficient DNA or a technical issue prevented analysis; re-biopsy may be considered |
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
A few clinical situations can affect how results are interpreted:
- Standard PGT-SR analysis cannot distinguish between an embryo with completely normal chromosomes and one that carries the same balanced rearrangement as the parent. Both would appear as suitable for transfer, but a child born from a balanced-carrier embryo may face similar reproductive considerations later in life.
- Advanced maternal age increases the likelihood of de novo aneuploidies, which arise independently of the parental structural rearrangement and may affect results.
- Poor embryo quality or a small biopsy sample may lead to amplification failure, resulting in an inconclusive report for one or more embryos.
How to Maintain Healthy Levels
While chromosomal outcomes in embryos cannot be changed through lifestyle measures, the following steps support the best possible outcomes during the IVF and PGT SR - 6 Embryos Test process:
- Work with experienced fertility and genetics specialists who have familiarity with structural rearrangements.
- Complete both pre-test and post-test genetic counselling sessions to fully understand your options.
- Consider confirmatory prenatal testing, such as CVS (chorionic villus sampling) or amniocentesis, after a successful embryo transfer and positive pregnancy test.
Lupin Diagnostics PGT SR - 6 Embryos Test Price
The PGT SR - 6 Embryos Test cost at Lupin Diagnostics starts at ₹86,500. This test requires a visit to a Lupin Diagnostics centre or coordination with your IVF centre for sample dispatch. Home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 86500 |
| CHENNAI | 86500 |
| HYDERABAD | 86500 |
| KOLKATA | 86500 |
| NAVI MUMBAI | 86500 |
| PUNE | 86500 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
The following steps explain how to arrange your PGT SR - 6 Embryos Test online booking:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time, or coordinate with your IVF clinic for sample collection and dispatch using the designated PGT Collection Kit.
- Receive your report via email or WhatsApp within 18 days of sample receipt.
Frequently Asked Questions
PGT-SR screens embryos specifically for chromosomal imbalances caused by a known structural rearrangement (such as a translocation or inversion) carried by a parent. PGT-A, by contrast, screens any IVF patient's embryos for aneuploidy (an incorrect number of whole chromosomes), regardless of parental chromosomal status. Both tests use NGS-based analysis of embryo biopsy cells.
This test is recommended for couples where one or both partners have a confirmed balanced chromosomal rearrangement, often identified after recurrent miscarriages or after the birth of a child with a chromosomal condition. Genetic counselling before starting IVF is strongly recommended to determine whether this test is appropriate for your situation.
The patient undergoes a standard IVF cycle, including ovarian stimulation, egg retrieval, and fertilisation. The biopsy itself is performed by the embryologist on the embryos in the laboratory, not directly on the patient. Embryos are frozen after biopsy while the genetic results are awaited.
Results are delivered within 18 days of the laboratory receiving the biopsy samples. Your fertility clinic will coordinate the sample dispatch and will inform you once the results are available for review.
No. The PGT SR - 6 Embryos Test significantly improves the chances of selecting chromosomally suitable embryos and can reduce the risk of miscarriage related to structural rearrangements. However, no genetic test can guarantee a successful pregnancy or rule out all possible conditions.
If all tested embryos are found to be unbalanced or aneuploid, your fertility specialist will discuss the next steps. These may include undergoing another IVF cycle to create additional embryos, or exploring alternative options such as the use of donor eggs or donor sperm.
Yes. Confirmatory prenatal testing, such as CVS or amniocentesis, is recommended after a positive pregnancy test. This provides additional assurance about the chromosomal status of the pregnancy. A child born following a normal PGT-SR result may also benefit from chromosome testing before starting their own family.
PGT SR - 6 Embryos Test: Booking, Price, and Results
