PGT SR - 10 Embryos Test: Booking, Price, and Results
About PGT SR - 10 Embryos Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | PGT-SR, Preimplantation Genetic Testing for Structural Rearrangements (10 Embryos), PGD for Chromosomal Rearrangements |
| Sample Type | Trophectoderm biopsy cells (cells from the outer layer of a day-5 or day-6 embryo) |
| Fasting Required | Not applicable, this test is performed on embryo cells, not on a patient's blood or urine sample |
| Report Time | 18 days |
| Recommended For | Couples where one or both partners carry a known balanced chromosomal structural rearrangement, undergoing IVF |
| Price | Starting at ₹1,44,000 |
What Is a PGT SR - 10 Embryos Test?
The PGT SR - 10 Embryos Test is a specialised genetic test performed on embryos created through in vitro fertilisation (IVF). It screens up to ten embryos for chromosomal structural problems arising from a known rearrangement carried by one or both parents. The test analyses a small number of cells carefully removed from each embryo and uses next-generation sequencing (NGS) to examine all 23 chromosome pairs. It is also referred to as PGT-SR or Preimplantation Genetic Testing for Structural Rearrangements.
What Does a PGT SR - 10 Embryos Test Measure?
This test examines embryo cells for chromosomal problems linked to a parental structural rearrangement. The table below summarises what is assessed.
| What Is Analysed | What It Means |
|---|---|
| Unbalanced Chromosomal Rearrangements | Extra or missing chromosomal material resulting from a parental structural rearrangement, such as a translocation or inversion |
| Numerical Chromosome Abnormalities (Aneuploidies) | Extra or missing whole chromosomes, such as trisomies or monosomies |
| Segmental Gains or Losses | Deletions or duplications of chromosomal segments that may affect embryo viability or development |
| All 23 Chromosome Pairs | Genome-wide assessment of all chromosome pairs to identify chromosomal imbalances in each embryo |
Why Is a PGT SR - 10 Embryos Test Done?
Unlike most diagnostic tests, this procedure is not triggered by patient symptoms. It is indicated based on a couple's reproductive history and genetic background.
Common Indications for This Test
The following situations commonly lead a fertility specialist to recommend the PGT SR - 10 Embryos Test:
- Known balanced translocation or inversion in one or both partners
- Recurrent miscarriage (two or more pregnancy losses)
- Recurrent implantation failure during previous IVF cycles
- Previous pregnancy was confirmed to have a chromosomal abnormality
- Offspring with developmental delays, intellectual disabilities, or congenital differences
- Unexplained infertility linked to chromosomal factors
Conditions This Test Can Help Identify
The test helps identify embryos affected by the following chromosomal situations:
- Reciprocal translocations (segments of two chromosomes have swapped places)
- Robertsonian translocations (two specific chromosomes have joined together)
- Chromosomal inversions (a segment of a chromosome is reversed in orientation)
- Complex chromosomal rearrangements involving more than two chromosomes
- Whole-chromosome aneuploidy unrelated to the parental rearrangement
How to Prepare and What to Expect
Preparation for this test takes place at the IVF clinic level, not at home. The steps below explain what to expect across the full process.
Do You Need to Fast?
No fasting is required. Standard pre-IVF medical advice from your fertility specialist applies.
Practical Tips Before Your Test
The following steps are important to complete before the PGT SR - 10 Embryos Test procedure can begin:
- Both partners should complete a full karyotype analysis (chromosome test from a blood sample) before the IVF cycle starts
- Bring detailed genetic and reproductive history records to every clinic appointment, as parental reports for structural variations are mandatory for this test
- Attend genetic counselling before the cycle begins to understand your specific rearrangement, expected embryo outcomes, and test limitations
- Share all current medications and supplements with your fertility specialist
- Follow all ovarian stimulation and egg retrieval instructions from your clinic to maximise blastocyst numbers available for testing
Step-by-Step Procedure
- Eggs are retrieved from the female partner and fertilised with sperm in the laboratory, usually using ICSI (intracytoplasmic sperm injection)
- Fertilised eggs are cultured in the laboratory for five to six days until they develop into blastocysts.
- A trained embryologist performs a trophectoderm biopsy: a laser is used to open the outer shell of the blastocyst, and five to eight cells are gently removed from the outer layer. The inner part of the embryo, which forms the baby, is not touched.
- Each biopsied embryo is immediately frozen (vitrified) and stored safely while testing takes place.
- The biopsied cells are sent to the genetics laboratory, where DNA is amplified and analysed using NGS to examine all 23 chromosome pairs for imbalances.
- Results are reviewed by a fertility specialist and genetic counsellor, who discuss the outcome with the couple and advise on which embryos, if any, are suitable for transfer.
Factors That Can Affect Accuracy
The following factors may influence the reliability of the test result:
- Embryo mosaicism (where cells within the same embryo carry different chromosomal compositions)
- Quality of the trophectoderm biopsy sample obtained
- Inclusion of lower-quality or delayed blastocysts in the testing batch
- The specific type of chromosomal rearrangement and the exact location of its breakpoints
Understanding Your PGT SR - 10 Embryos Test Results
Each embryo receives a categorical outcome, which your fertility specialist and genetic counsellor will explain in the context of your specific rearrangement and reproductive history.
| Result Category | Meaning | Next Step |
|---|---|---|
| Euploid / Balanced | No detectable chromosomal imbalance was identified in the embryo | Generally considered for transfer |
| Unbalanced / Aneuploid | Extra, missing, or unbalanced chromosomal material detected | Generally not selected for transfer |
| Mosaic (if reported) | Evidence of both normal and abnormal chromosomal cell populations | Genetic counselling and specialist review are recommended before any transfer decision |
| Inconclusive / No Result | No reliable result obtained, often due to insufficient DNA or technical limitations | Repeat testing or re-biopsy may be considered |
Disclaimer: These categories are general guidelines. Your doctor will interpret your results based on your specific chromosomal rearrangement, reproductive history, and overall clinical picture. Always consult a qualified fertility specialist and genetic counsellor for personalised medical advice.
Results During Special Conditions
Embryo mosaicism is an important factor to be aware of. When the cells within an embryo do not all share the same chromosomal makeup, the biopsy sample may not fully represent the entire embryo.
Studies have shown that complete agreement between the biopsied outer-layer cells and the whole embryo is seen in approximately 68% of cases, meaning some level of discordance can occur. This is an inherent limitation of trophectoderm biopsy-based testing and should be discussed with your genetic counsellor.
How to Maintain Healthy Levels
While embryo chromosomal outcomes cannot be controlled directly, the following steps support the best possible cycle conditions:
- Ensure both partners complete karyotype analysis well before the IVF cycle begins to allow adequate preparation time
- Attend all recommended genetic counselling sessions to make informed decisions about embryo transfer
- Follow the fertility specialist's guidance on stimulation protocols and embryo culture conditions to encourage the development of good-quality blastocysts
Lupin Diagnostics PGT SR - 10 Embryos Test Price
The PGT SR - 10 Embryos Test cost at Lupin Diagnostics starts at ₹1,44,000. This test requires a visit to a Lupin Diagnostics centre or affiliated IVF laboratory; home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 144000 |
| CHENNAI | 144000 |
| HYDERABAD | 144000 |
| KOLKATA | 144000 |
| NAVI MUMBAI | 144000 |
| PUNE | 144000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time; embryo biopsy samples are collected and dispatched from the IVF laboratory in coordination with your fertility clinic.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
PGT-SR specifically targets chromosomal structural rearrangements in couples where one or both partners carry a known balanced translocation or inversion. PGT-A, by contrast, screens any IVF patient's embryos for the wrong number of chromosomes, without requiring a known parental rearrangement.
This test is recommended for couples where one or both partners have been confirmed to carry a balanced chromosomal structural rearrangement. It is particularly relevant for those with a history of recurrent miscarriages, recurrent IVF implantation failure, or a previous pregnancy with chromosomal abnormalities linked to a known translocation or inversion.
The "10 Embryos" designation means the package covers genetic analysis of up to ten blastocysts from a single IVF stimulation cycle. If fewer than ten embryos develop to the blastocyst stage, only those available are tested. Batch pricing typically makes the per-embryo cost lower than testing each embryo individually.
At the blastocyst stage, five to eight cells can be removed from the outer layer (trophectoderm) without touching the inner cell mass, which is the part of the embryo that develops into the baby. The procedure is performed by trained embryologists using a laser-assisted technique, and available studies have not shown significant increases in birth defect rates following trophectoderm biopsy.
No. The PGT SR test reduces the risk of transferring a chromosomally unbalanced embryo, which in turn lowers the risk of miscarriage and chromosomally affected pregnancies. However, it cannot screen for single-gene disorders or all possible causes of pregnancy complications. Confirmatory prenatal testing, such as amniocentesis, is recommended if a pregnancy is achieved after transfer.
Report delivery for the PGT SR - 10 Embryos Test at Lupin Diagnostics is 18 days from the time of embryo biopsy.
No. The trophectoderm biopsy must be performed by a qualified embryologist inside a specialised IVF laboratory. There is no home collection option for this test.
PGT SR - 10 Embryos Test: Booking, Price, and Results
