PGT SR - 1 Embryo Test: Booking, Price, and Results
About PGT SR - 1 Embryo Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | PGT-SR, Preimplantation Genetic Testing for Structural Rearrangements, PGD for Translocations, Chromosomal Rearrangement Testing |
| Sample Type | Embryo biopsy (trophectoderm cells from Day 5 or Day 6 blastocyst) |
| Fasting Required | Not applicable. This test is performed on embryo cells, not on the patient directly. |
| Report Time | 18 days |
| Recommended For | Couples where one or both partners carry a known chromosomal structural rearrangement, such as a translocation or inversion |
| Price | Starting at ₹18,000 |
What Is a PGT SR - 1 Embryo Test?
The PGT SR - 1 Embryo Test analyses a small sample of cells taken from a developing embryo during an IVF cycle. It checks whether the embryo carries chromosomal imbalances caused by a structural rearrangement inherited from one or both parents. It is also known as Preimplantation Genetic Testing for Structural Rearrangements or PGT-SR. The test helps fertility specialists identify which embryos are suitable for transfer, reducing the risk of miscarriage or a chromosomally affected pregnancy.
What Does a PGT SR - 1 Embryo Test Measure?
The PGT SR - 1 Embryo Test procedure uses next-generation sequencing (NGS) technology to examine the DNA of embryo cells. It looks at chromosomal structure and number across the entire genome.
The key areas assessed are listed below.
| Parameter | What It Checks |
|---|---|
| Chromosomal balance | Whether the embryo has the correct amount of genetic material overall |
| Reciprocal translocations | Sections of two chromosomes that have swapped positions |
| Robertsonian translocations | Fusion of two specific chromosomes into one |
| Chromosomal inversions | A segment within a chromosome that has flipped orientation |
| Aneuploidy | Extra or missing whole chromosomes unrelated to the parental rearrangement |
Why Is a PGT SR - 1 Embryo Test Done?
Couples with a known chromosomal structural rearrangement face a higher risk of miscarriage, implantation failure, or having a child with chromosomal abnormalities. The PGT SR - 1 Embryo Test helps select chromosomally suitable embryos before transfer.
Common Symptoms That May Require This Test
A fertility specialist may recommend this test in the following situations.
- Recurrent miscarriages (two or more consecutive pregnancy losses)
- Repeated implantation failure despite good-quality embryos
- Known balanced translocation or chromosomal inversion in one or both partners
- A previous child born with a chromosomal abnormality
- A family history of structural chromosomal rearrangements
- Unexplained infertility in couples confirmed to carry a rearrangement
Conditions This Test Can Help Detect
The test can identify the following chromosomal issues in embryos.
- Reciprocal translocations, which account for 2 to 5% of recurrent miscarriage cases
- Robertsonian translocations
- Chromosomal inversions
- Unbalanced rearrangements that can result in developmental delays or congenital abnormalities in a child
- Segmental aneuploidies (extra or missing pieces of chromosomes)
How to Prepare and What to Expect
The PGT SR - 1 Embryo Test is a highly specialised genetic test performed on embryo cells within an IVF programme. Preparation involves several steps before and during the IVF cycle.
Do You Need to Fast?
No fasting is required. This test is not performed on a blood or urine sample from the patient. The sample is taken from the embryo itself during the IVF process.
Practical Tips Before Your Test
The following steps are important before proceeding with the test.
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test.
- Carry all past reproductive and genetic reports, including karyotype results confirming the chromosomal rearrangement.
- Bring a duly filled Test Request Form (TRF) and biopsy worksheet, along with a signed consent form.
- Both partners are advised to undergo genetic counselling before starting the IVF cycle.
- A high-resolution karyotype confirming the exact chromosomal breakpoints must be available before the test can begin.
- ICSI (intracytoplasmic sperm injection, where a single sperm is injected directly into the egg) is the preferred fertilisation method when PGT-SR is planned.
Step-by-Step Procedure
- The IVF cycle is completed, and embryos are allowed to develop to the blastocyst stage, typically by Day 5 or Day 6.
- A trained embryologist uses a microsurgical needle to remove 5 to 8 cells from the trophectoderm, which is the outer cell layer of the blastocyst that would form the placenta. This step involves a laser-assisted opening of the embryo's protective shell.
- While the biopsy cells are sent for genetic analysis, the embryo is cryopreserved (frozen) and stored safely until results are ready.
- The biopsy sample is transported on dry ice to the Lupin Diagnostics laboratory, where NGS technology is used to analyse the chromosomal DNA.
- Results are reviewed by a genetic specialist, and a detailed report is prepared.
Factors That Can Affect Accuracy
The following factors can influence the reliability of test results.
- Quality of the embryo at the time of biopsy
- The technique used during trophectoderm biopsy
- Timing of the biopsy (Day 5 to Day 7 is preferred)
- Laboratory expertise in handling and processing embryo samples
- Insufficient sample quantity or DNA amplification failure
Understanding Your PGT SR - 1 Embryo Test Results
Your fertility doctor will review your results and explain what they mean for your embryo transfer plan. The table below provides a general guide to how results are typically classified.
| Result Category | Meaning | Implication |
|---|---|---|
| Euploid (Normal) | Normal chromosomal complement with no detected imbalance | Generally considered suitable for transfer |
| Balanced | Structural rearrangement present, but no net gain or loss of genetic material | May be suitable for transfer; genetic counselling may be recommended |
| Aneuploid (Abnormal) | Extra or missing chromosome(s) or an unbalanced chromosomal rearrangement detected | Generally not selected for transfer |
| Mosaic | Evidence of both normal and abnormal chromosomal cell populations | Requires individualised review and counselling by a fertility specialist |
| Inconclusive | No reliable result obtained due to insufficient DNA or technical limitations | Repeat testing or re-biopsy may be considered |
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
How to Maintain Healthy Levels
- Attend genetic counselling sessions before and after the IVF cycle to understand your results fully.
- After a successful transfer and confirmed pregnancy, discuss confirmatory testing such as CVS (chorionic villus sampling) or amniocentesis with your doctor, as these are recommended following a PGT-SR cycle.
- Keep all medical records and past genetic reports organised, as they are essential for your fertility team's decision-making.
Lupin Diagnostics PGT SR - 1 Embryo Test Price
The PGT SR - 1 Embryo Test cost at Lupin Diagnostics starts at ₹18,000 per embryo. This test requires a visit to a Lupin Diagnostics centre or an associated IVF facility; home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 18000 |
| CHENNAI | 18000 |
| HYDERABAD | 18000 |
| KOLKATA | 18000 |
| NAVI MUMBAI | 18000 |
| PUNE | 18000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time for sample submission, ensuring you carry all required documents (TRF, biopsy worksheet, consent form, and clinical history).
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
PGT-SR stands for Preimplantation Genetic Testing for Structural Rearrangements. It is specifically designed for couples where one partner carries a chromosomal structural rearrangement, such as a translocation or inversion. Other PGT tests include PGT-A (for abnormal chromosome number) and PGT-M (for single gene disorders). Each test targets a different category of genetic risk.
This test is recommended for any individual who carries a confirmed chromosomal structural rearrangement and is therefore at higher risk of miscarriage or having a child with a chromosomal disorder. It is particularly relevant for couples who have experienced multiple miscarriages or repeated implantation failure during IVF.
At Lupin Diagnostics, the report is delivered within 18 days from receipt of the biopsy sample. This allows sufficient time for the laboratory to complete NGS analysis and for your fertility team to plan the embryo transfer accordingly.
Trophectoderm biopsy, which removes 5 to 8 cells from the outer layer of the blastocyst, has been shown to have little or no negative impact on the embryo's ability to implant. The inner cell mass, which forms the baby, is left completely untouched during the procedure.
No. This test can only detect unbalanced chromosomal rearrangements. It cannot identify the balanced form of a structural rearrangement, where no genetic material is gained or lost. It also cannot detect single-gene disorders such as cystic fibrosis or sickle cell anaemia. A separate PGT-M test would be needed for those conditions.
This varies depending on the type of rearrangement carried by the parents. Research shows that the proportion of suitable embryos ranges from approximately 22.5% for reciprocal translocation carriers to around 44.6% for those with certain inversions. Your fertility specialist can give you a more personalised expectation based on your specific situation.
Yes. Leading medical bodies recommend confirmatory prenatal testing, such as CVS or amniocentesis, after pregnancy is established, even when the embryo is tested normal on PGT-SR. This is because PGT-SR, while highly accurate, is a screening test, and confirmatory testing provides an additional level of assurance. Speak with your doctor about the best option for you.
PGT SR - 1 Embryo Test: Booking, Price, and Results
