PGT-A (7 Embryos) Test: Booking, Price, and Results
About PGT-A (7 Embryos) Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | PGT-A, Preimplantation Genetic Testing for Aneuploidy, PGS, Embryo Chromosomal Screening |
| Sample Type | Embryo biopsy (Day 5 or Day 6 trophectoderm cells from blastocyst-stage embryo) |
| Fasting Required | Not applicable — the test is performed on embryo cells, not a patient's blood or urine sample |
| Report Time | 18 days after biopsy submission |
| Recommended For | Couples undergoing IVF; especially women aged 35 and above, those with recurrent miscarriage, repeated IVF failure, or a family history of chromosomal conditions |
| Price | Starting at ₹70,000 |
What is a PGT-A (7 Embryos) Test?
The PGT-A test — short for Preimplantation Genetic Testing for Aneuploidy — is a genetic screening procedure carried out during an IVF cycle. It checks embryos for abnormal chromosome numbers before they are transferred to the uterus. This version of the PGT-A test covers up to seven embryos in a single cycle. It is also known as PGS or Embryo Chromosomal Screening.
What Does a PGT-A (7 Embryos) Test Measure?
The PGT-A test procedure analyses all 23 chromosome pairs in each embryo's cells. The goal is to identify whether each embryo has the correct number of chromosomes. Using Next Generation Sequencing (NGS), the lab classifies every embryo into one of the following categories:
| Category | What it Means |
|---|---|
| Euploid | The embryo has the correct 46 chromosomes and is considered chromosomally normal |
| Aneuploid | The embryo has extra or missing chromosomes, making it chromosomally abnormal |
| Mosaic | The embryo contains a mix of normal and abnormal cells (30% to 70% abnormal cells) |
| Inconclusive | The biopsy did not yield a usable result; this does not indicate an abnormality |
Why is a PGT-A (7 Embryos) Test Done?
Doctors recommend the PGT-A test when the risk of chromosomal abnormalities in embryos is higher than usual. Below are the key reasons this test is requested.
Common Clinical Situations Requiring This Test
- Recurrent miscarriage (two or more pregnancy losses)
- Multiple failed IVF cycles without a clear explanation
- Advanced maternal age (35 years and above)
- Prior pregnancy affected by a chromosomal condition
- Family history of chromosomal abnormalities
- Abnormal results on sperm DNA fragmentation testing
- Desire to reduce the risk of transferring a chromosomally abnormal embryo
Conditions This Test Can Help Detect
The PGT-A test can identify embryos affected by a range of chromosomal conditions, including:
- Trisomy 21 (Down syndrome) — an extra copy of chromosome 21
- Trisomy 18 (Edwards syndrome) — an extra copy of chromosome 18
- Trisomy 13 (Patau syndrome) — an extra copy of chromosome 13
- Turner syndrome and Klinefelter syndrome — sex chromosome abnormalities
- Monosomies — embryos missing one chromosome from a pair
- Complex or segmental chromosomal abnormalities
How to Prepare and What to Expect
Because this test is performed on embryo cells rather than a patient's blood or urine, preparation is quite different from a routine diagnostic test. The process takes place entirely within an IVF laboratory setting.
Do You Need to Fast?
Fasting is not required. The PGT-A test procedure analyses cells biopsied from embryos, so there are no dietary restrictions for the patient before or during the process.
Practical Tips Before Your Test
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test.
- Carry a duly filled Test Request Form (TRF), biopsy worksheet, and signed consent form to the IVF centre.
- Attend a genetic counselling session beforehand to understand what euploid, aneuploid, and mosaic results mean for your situation.
- Discuss with your fertility specialist whether PGT-A is suitable based on your age, the number of embryos available, and your previous cycle history.
- Be aware that all embryos biopsied will be frozen immediately after the procedure, and transfer will occur in a separate frozen embryo transfer (FET) cycle.
Step-by-Step Procedure
- Eggs are retrieved from the female partner and fertilised with sperm in the IVF laboratory to create embryos.
- The embryos are cultured for five to six days until they reach the blastocyst stage.
- On Day 5 or Day 6, an embryologist carefully removes five to eight cells from the trophectoderm — the outer layer of the embryo that later forms the placenta. This biopsy does not harm the embryo itself.
- Immediately after biopsy, each embryo is vitrified (rapidly frozen) and stored safely while testing proceeds.
- The biopsied cells are packed using the PGT Collection Kit and transported on dry ice to the genetics laboratory, where NGS analysis is performed.
- Results are reported within 18 days. Your fertility specialist reviews the findings and discusses which embryos are suitable for transfer.
Factors That Can Affect Accuracy
Several factors can influence the reliability of PGT-A test results:
- Mosaicism within the embryo — not all cells carry the same chromosomal makeup, which can affect interpretation
- Quality and timing of the embryo biopsy
- The developmental stage of the embryo at the time of biopsy
- Laboratory expertise and the technology platform used
- Advanced maternal or paternal age, which is associated with higher rates of chromosomal abnormalities
Understanding Your PGT-A (7 Embryos) Test Results
Your results will classify each embryo tested. A fertility specialist or genetic counsellor will explain the findings in the context of your individual situation.
| Result | Description | Clinical Notes |
|---|---|---|
| Euploid | 46 chromosomes; chromosomally normal | Suitable for transfer; approximately 60% chance of live birth |
| Aneuploid | Incorrect chromosome number | Generally not recommended for transfer; live birth rate is 0 to 1% |
| Mosaic | 30% to 70% of cells are abnormal | Transfer may be considered in selected cases; live birth rate is 15% to 45% |
| Inconclusive | Biopsy did not yield a result | Does not indicate abnormality; repeat biopsy may be discussed |
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Maternal age has a significant effect on aneuploidy rates. In women aged 35 to 39, approximately 40% to 50% of embryos may be aneuploid. In women over 40, this figure rises to more than 50%. In women under 30, the aneuploidy rate is closer to 27%. Advanced paternal age is also associated with higher rates of chromosomal abnormalities in embryos.
How to Maintain Healthy Levels
While chromosomal abnormalities in embryos are largely age-related and cannot be prevented, certain general wellness habits may support overall reproductive health:
- Follow a balanced diet rich in folate, antioxidants, and whole foods before and during an IVF cycle
- Avoid smoking, alcohol, and excessive stress, as these can affect egg and sperm quality
- Speak with your fertility specialist about any supplements or lifestyle changes appropriate for your situation
Lupin Diagnostics PGT-A (7 Embryos) Test Price
The PGT-A test cost at Lupin Diagnostics starts at ₹70,000 for seven embryos. This test requires a visit to an authorised IVF centre for sample collection; home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 70000 |
| CHENNAI | 70000 |
| HYDERABAD | 70000 |
| KOLKATA | 70000 |
| NAVI MUMBAI | 70000 |
| PUNE | 70000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Follow these steps to book your PGT-A test online with Lupin Diagnostics:
- Select the PGT-A (7 Embryos) test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre or your IVF clinic at your scheduled time for sample collection.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
The PGT-A test checks embryos created during IVF for the correct number of chromosomes. It helps fertility specialists identify chromosomally normal embryos, which may improve the chances of a successful pregnancy and reduce the risk of miscarriage.
PGT-A is generally recommended for women over 40, those with a history of recurrent pregnancy loss, couples who have had multiple failed IVF cycles, and those with a known family history of chromosomal conditions. Your fertility specialist will advise whether this test is appropriate for your situation.
Around Day 5 or Day 6 after fertilisation, an embryologist removes a small number of cells from the outer layer of each embryo. This outer layer forms the placenta and not the baby itself. The procedure is safe and does not damage the embryo.
NGS-based PGT-A has an estimated accuracy of around 98%. However, a biological limitation called mosaicism — where not all cells in an embryo share the same chromosomal makeup — can affect results. False positive rates are estimated between 5% and 10%.
A mosaic result means the embryo contains a mix of chromosomally normal and abnormal cells. Transfer of a mosaic embryo may still be considered in some cases, and healthy live births following mosaic embryo transfers have been reported. Your fertility specialist will guide you based on the specific chromosomes involved and your overall situation.
No. PGT-A only screens for abnormalities in chromosome number. It does not detect single-gene disorders or all possible genetic conditions. Prenatal testing during pregnancy is still recommended even after transferring a PGT-A-tested euploid embryo.
Results are typically available within 18 days of the biopsy being submitted to the laboratory. During this time, all biopsied embryos are kept safely frozen until the findings are ready and reviewed by your specialist.
PGT-A (7 Embryos) Test: Booking, Price, and Results
