Oncomine Focus Panel-77 Genes Test: Booking, Price, and Results
About Oncomine Focus Panel-77 Genes Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Oncomine Focus Assay, NGS Solid Tumour Panel, Targeted NGS Cancer Panel |
| Sample Type | FFPE Tissue Block (formalin-fixed paraffin-embedded tumour tissue) |
| Fasting Required | No |
| Report Time | 30 days |
| Recommended For | Adults with confirmed solid tumours requiring targeted therapy guidance |
| Price | Starting at ₹33,600 |
What Is an Oncomine Focus Panel-77 Genes Test?
The Oncomine Focus Panel-77 Genes test is a specialised next-generation sequencing (NGS) test that analyses tumour tissue for genetic changes across 77 cancer-related genes. It is prescribed by oncologists to identify specific mutations, gene amplifications, and gene fusions that may influence treatment choices. The sample used is an FFPE tissue block, obtained from a prior biopsy or surgical procedure. This test is also referred to as the Oncomine focus assay, NGS solid tumour panel, or targeted NGS cancer panel.
What Does an Oncomine Focus Panel-77 Genes Test Measure?
The Oncomine Focus Panel-77 Genes test analyses tumour DNA and RNA to detect three types of genetic changes: single nucleotide variants and small insertions or deletions (mutations at specific hotspots), copy number variations (extra or missing copies of a gene), and gene fusions or rearrangements. These findings help oncologists identify which targeted therapies may be effective.
The following genes are analysed as part of this panel:
| Gene Category | Genes Tested |
|---|---|
| Kinases and receptors | ABL1, AKT1, AKT3, ALK, AR, AXL, DDR2, EGFR, ERBB2, ERBB3, ERBB4, FGFR1, FGFR2, FGFR3, FGFR4, JAK1, JAK2, JAK3, KIT, MAP2K1, MAP2K2, MET, MTOR, NTRK1, NTRK2, NTRK3, PDGFRA, RAF1, RET, ROS1, SMO |
| Oncogenes and transcription factors | BRAF, CCND1, CDK4, CDK6, CTNNB1, ERG, ESR1, ETV1, ETV4, ETV5, GNA11, GNAQ, HRAS, IDH2, KRAS, MYC, MYCN, NRAS, PIK3CA, PPARG |
| Fusion and rearrangement targets | ALK, BRAF, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK2, NTRK3, PDGFRA, RAF1, RET, ROS1 |
Each genetic change detected may point to a specific targeted therapy that could be considered in your cancer care.
Why Is an Oncomine Focus Panel-77 Genes Test Done?
This test is requested when an oncologist needs detailed genetic information about a tumour to guide treatment decisions. It is particularly useful for advanced or metastatic cancers where targeted therapies are available.
Common Symptoms That May Require This Test
A doctor may recommend this test when a patient has already been diagnosed with cancer and presents with signs of advanced disease. The following situations commonly lead to this test being ordered:
- Advanced or metastatic solid tumour requiring treatment planning
- Disease progression despite initial therapy
- Cancer with known actionable mutation patterns (e.g., lung, colorectal, thyroid)
- Tumour type known to respond to targeted therapies
- Recurrence after prior treatment
- Need to identify resistance mechanisms to current therapy
Conditions This Test Can Help Detect
The Oncomine Focus Panel-77 Genes test helps guide therapy selection in several cancer types. Below are the conditions where this test is commonly used:
- Non-small cell lung cancer (NSCLC)
- Colorectal cancer
- Melanoma
- Thyroid cancer
- Gastrointestinal stromal tumours (GISTs)
- Gastric cancer
- Cholangiocarcinoma (bile duct cancer)
How to Prepare and What to Expect
This test requires no special preparation on your part, as the sample is tumour tissue already collected during a biopsy or surgery. However, there are important practical steps to follow when submitting the sample.
Do You Need to Fast?
No fasting is required. This test uses an FFPE tissue block from a tumour biopsy or surgical specimen, not a blood or urine sample. Always follow specific instructions provided by your doctor.
Practical Tips Before Your Test
Preparing the correct documentation and ensuring sample quality are essential for reliable results. The following steps will help the process go smoothly:
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test
- Provide the histopathology report from the biopsy or surgery that produced the tissue block
- Inform your doctor about all prior biopsies or surgical specimens, including their dates and locations
- FFPE blocks less than 5 years old generally yield better DNA and RNA quality; mention older specimens to your doctor
Step-by-Step Procedure
- A tumour tissue sample is collected through a biopsy or during surgery. This step is performed by a doctor or surgeon at a healthcare facility.
- The collected tissue is preserved using a standard method called formalin fixation and then embedded in paraffin wax.
- The block is cut into very thin sections (5 microns), and the wax is removed in the laboratory before analysis begins.
- DNA and RNA are extracted from the tissue, amplified, and prepared into sequencing libraries.
- The prepared libraries are run through NGS technology, which reads the genetic sequences in the tumour sample.
- Results are processed, and a clinical report is generated and delivered within 30 days.
Factors That Can Affect Accuracy
Several factors can influence how reliable the results are. These include:
- Low tumour content in the tissue sample
- Age and fixation quality of the FFPE block, as older or poorly fixed samples may have degraded DNA
- Use of zinc fixative or decalcification processing, which can damage nucleic acids
- Tumour heterogeneity, meaning a single biopsy may not capture all mutations present across the tumour
Understanding Your Oncomine Focus Panel-77 Genes Test Results
This test does not produce numerical values. It is a qualitative test, meaning it reports whether specific genetic changes are present or absent. Your oncologist or molecular pathologist will interpret the findings in the context of your cancer type and treatment history. The table below shows general reference for test results:
| Finding | What It Means |
|---|---|
| No pathogenic variant detected | No actionable mutations found in the genes tested; standard treatment protocols apply |
| Pathogenic or likely pathogenic variant | A clinically significant mutation is identified; this may influence treatment decisions |
| Variant of uncertain significance (VUS) | A genetic change is found but its clinical relevance is not yet established; further evaluation is needed |
| Gene amplification | An increased number of gene copies is detected; this may indicate sensitivity or resistance to specific therapies |
| Gene fusion positive | A gene rearrangement is detected; this may indicate eligibility for a specific targeted therapy |
Disclaimer: These findings are general guidelines. Your doctor will interpret your results based on your cancer type, clinical stage, health history, and available therapies. Always consult a qualified healthcare professional for personalised medical advice.
How to Maintain Healthy Levels
Because this test is used for cancer diagnosis and treatment guidance, results cannot be altered through lifestyle changes. The following general steps are still useful:
- Follow your oncologist's treatment recommendations closely based on the panel findings
- Attend all scheduled follow-up appointments so your care team can monitor your response to therapy
- Consider genetic counselling if you wish to better understand the implications of specific findings for yourself or your family
Lupin Diagnostics Oncomine Focus Panel – 77 Genes Test Price
The Oncomine Focus Panel-77 Genes test cost starts at ₹33,600 at Lupin Diagnostics. This test requires a visit to a hospital or submission of the FFPE tissue block through your treating hospital at the Lupin Diagnostics centre; home collection is not available for this test. The table below shows indicative prices:
| City | Approximate Price ( ₹) |
|---|---|
| BHOPAL | 33600 |
| CHENNAI | 33600 |
| HYDERABAD | 33600 |
| KOLKATA | 33600 |
| NAVI MUMBAI | 33600 |
| PUNE | 33600 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time, or coordinate with your treating hospital to submit the FFPE tissue block directly to the laboratory.
- Receive your report via email or WhatsApp within 30 days.
Frequently Asked Questions
This test is used to identify specific genetic mutations, gene amplifications, and gene fusions in a tumour sample. The results help oncologists decide whether a patient may benefit from targeted therapies. It is not a cancer screening test and is performed only after a cancer diagnosis has been made.
Not necessarily. Archived FFPE tissue blocks from a previous biopsy or surgery can be submitted. However, fresher samples generally produce better-quality DNA and RNA, leading to more reliable results. Your doctor will advise whether your existing sample is suitable.
The Oncomine Focus Panel-77 Genes test analyses solid tumour tissue preserved in an FFPE block, while a liquid biopsy analyses tumour DNA circulating in the blood. Tissue-based testing is generally considered more complete, though liquid biopsy may be used when tissue is unavailable or insufficient.
A result showing no pathogenic variants means the 77 genes tested did not reveal any known mutations in your tumour tissue. This does not mean the cancer is unresponsive to all treatment. Your oncologist will discuss other treatment approaches, such as chemotherapy or immunotherapy, based on your cancer type and stage.
At Lupin Diagnostics, results are delivered within 30 days from the date the laboratory receives the sample. The report is delivered directly via email or WhatsApp once it is ready.
No, Oncomine Focus Panel-77 Genes Test home collection is not available. This panel requires an FFPE tumour tissue block, which can only be obtained through a biopsy or surgical procedure at a medical facility.
The test identifies genetic mutations that are known to be associated with responses to certain targeted therapies. It does not guarantee a particular treatment outcome. Your oncologist will use the findings alongside other clinical information to decide the most appropriate treatment for you.
Oncomine Focus Panel-77 Genes Test: Booking, Price, and Results
