Home TestMyeov Igh Multiple Myeloma Test

MYEOV/IgH (MM) Test: Booking, Price, and Results

About MYEOV/IgH (MM) Test: Booking, Price, and Results

Field	Value
Also Known As	MYEOV/IGH Translocation Test, t(11;14) FISH Test, IgH/MYEOV Dual Fusion FISH Test, Cyclin D1/IgH Translocation Test, CCND1/IGH FISH Test
Sample Type	Bone marrow, peripheral blood, and FFPE tissue block
Fasting Required	No fasting required
Report Time	3 days
Recommended For	Adults of all genders with suspected or confirmed multiple myeloma, plasma cell neoplasms, or B-cell lymphoproliferative disorders
Price	Starting at ₹4,800

What Is a MYEOV/IgH (MM) Test?

The MYEOV/IgH (MM) test is a specialised genetic test that detects an abnormal exchange of genetic material between chromosomes 11 and 14. This exchange, known as the t(11;14) translocation, is associated with certain blood cancers, most notably multiple myeloma. The test uses a technique called FISH (fluorescence in situ hybridisation), which applies fluorescent probes to identify specific gene regions under a microscope. It is also known as the MYEOV/IGH translocation test, the t(11;14) FISH test, the IgH/MYEOV dual fusion FISH test, the cyclin D1/IgH translocation test, or the CCND1/IGH FISH test. Samples required for this test include bone marrow, peripheral blood, and FFPE tissue block.

What Does a MYEOV/IgH (MM) Test Measure?

This test looks for an abnormal exchange of genetic material between two chromosomes. It examines three key things:

Parameter	What It Looks For
MYEOV gene rearrangement	Checks whether the MYEOV gene (a gene with cancer-causing potential located on chromosome 11) has been displaced from its normal position
IGH gene rearrangement	Examines the IGH gene (which codes for part of the antibody structure) on chromosome 14 for any structural change
t(11;14) translocation	Detects whether genetic material has been swapped between chromosomes 11 and 14, a change associated with multiple myeloma and related conditions

Why Is a MYEOV/IgH (MM) Test Done?

Doctors order this test when there is clinical suspicion of a plasma cell disorder or a B-cell blood cancer. It supports both initial diagnosis and disease monitoring over time.

Common Symptoms That May Require This Test

Several symptoms may prompt a doctor to request this test. These include:

Unexplained fatigue and persistent weakness
Bone pain, particularly in the back, hips, or ribs
Anaemia (low red blood cell count) causing pallor or breathlessness
Frequent or recurring infections
Bone fractures without significant injury
Numbness or tingling in the arms and legs
Elevated protein levels detected in a routine blood test

Conditions This Test Can Help Detect

This test can assist in identifying a range of conditions affecting plasma cells and B-cells:

Multiple myeloma (MM), a blood cancer affecting plasma cells
Monoclonal gammopathy of undetermined significance (MGUS), a pre-cancerous plasma cell condition
Smouldering multiple myeloma (SMM), an early, inactive form of myeloma
Chronic lymphocytic leukaemia (CLL)
Non-Hodgkin lymphoma (NHL)

MYEOV/IgH (MM) Test for Chronic Disease Monitoring

This test plays an important role in tracking disease over time. It is recommended at initial diagnosis and again at disease relapse or progression to assist with risk classification and treatment planning. The IGH probe has shown strong performance both at the time of initial diagnosis and during follow-up care for myeloma patients.

How to Prepare and What to Expect

No special preparation is required for this test. Here is what you should know before the appointment.

Do You Need to Fast?

No fasting is required for the MYEOV/IgH (MM) test. You may eat and drink normally before your appointment. Always follow any specific instructions provided by your doctor.

Practical Tips Before Your Test

There are a few steps you can take to ensure the process goes smoothly:

Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test
Inform your doctor about all medications you are taking, especially blood thinners
Mention any known allergies, particularly to local anaesthetics (numbing agents)
Arrange for someone to accompany you, as you may feel mild discomfort after the bone marrow procedure
Wear comfortable, loose-fitting clothing to allow easy access to the collection site

Step-by-Step Procedure

This test requires three possible sample types: bone marrow, peripheral blood, and FFPE (formalin-fixed paraffin-embedded) tissue block. Here is what you should expect during the MM test procedure:

Bone Marrow Collection:

The back of the hip bone (posterior iliac crest) is the most common site for bone marrow aspiration.
The area is cleaned and numbed using a local anaesthetic injection.
A small cut is made in the skin, and a thin hollow needle is guided into the pelvic bone.
A syringe is attached to the needle, and a small amount of bone marrow (around 3 ml) is drawn out.
The sample is placed in a sodium heparin (green-top) tube and sent to the laboratory under refrigeration.
A small dressing is applied to the site after collection.

Peripheral Blood Collection:

A phlebotomist (trained blood collection specialist) cleans the inside of your elbow with an antiseptic swab.
A needle is inserted into a vein, and approximately 3 ml of blood is collected into a lavender-top EDTA tube.
The needle is removed, and light pressure is applied to stop any bleeding.
The sample is labelled and sent to the laboratory.

FFPE Tissue Block:

This sample is a preserved tissue block, usually from a prior biopsy.
The treating centre arranges transfer of the existing FFPE tissue block to the laboratory in an appropriate container.
No additional sample collection from the patient is required for this sample type.

Factors That Can Affect Accuracy

Certain conditions can influence the reliability of the test result:

Inadequate enrichment of plasma cells from the bone marrow sample may produce a false-negative result
A diluted bone marrow sample contaminated with peripheral blood (haemodilution) reduces accuracy
Low tumour burden in the sample can make the translocation harder to detect
Clotted or frozen specimens are not acceptable for FISH analysis
Delay in sample transport beyond 24 hours may affect specimen quality

Understanding Your MYEOV/IgH (MM) Test Results

Results from this test should always be reviewed by a qualified doctor, ideally a haematologist or oncologist, who can place them in the context of your clinical history and other findings. The table below shows the interpretation of test results:

Parameter	Normal (Negative) Result	Abnormal (Positive) Result
MYEOV/IGH fusion signal	No fusion detected	Fusion signal present
t(11;14) translocation	Not detected	Translocation detected

Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.

Results During Special Conditions

A few laboratory and clinical factors can affect how results are interpreted:

When plasma cells are not adequately separated from other bone marrow cells before FISH analysis, the translocation signal may be missed, leading to a false-negative result.
Low tumour burden in the sample reduces the number of abnormal cells available for analysis, which can lower detection sensitivity.
Haemodilution, where the bone marrow sample is diluted by peripheral blood, can also reduce the proportion of detectable abnormal cells.

How to Maintain Healthy Levels

Because the t(11;14) translocation is a genetic change, it cannot be prevented or reversed through lifestyle choices. However, general wellbeing supports overall health:

Follow a balanced diet with adequate nutrition as advised by your treating doctor.
Stay well hydrated and maintain reasonable physical activity within your comfort level.
Attend all scheduled follow-up appointments with your haematologist so that any disease changes are detected early.

Lupin Diagnostics MYEOV/IgH (MM) Test Price

The MM test cost starts at ₹4,800 at Lupin Diagnostics. This test requires a visit to a Lupin Diagnostics centre; home collection is not available for this test. The table below shows indicative prices across major Indian cities:

City	Approximate Price (₹)
BHOPAL	4800
CHENNAI	4800
HYDERABAD	4800
KOLKATA	4800
NAVI MUMBAI	4800
PUNE	4800

Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.

How to Book

Follow these steps for MM test online booking:

Select the test on the Lupin Diagnostics website.
Choose your city and preferred centre location.
Visit the centre at your scheduled time for sample collection.
Receive your report via email or WhatsApp within the stipulated turnaround time.

Frequently Asked Questions

The MYEOV/IgH (MM) test is used to detect a specific chromosomal translocation associated with multiple myeloma and other B-cell blood cancers, including chronic lymphocytic leukaemia and non-Hodgkin lymphoma. It helps doctors confirm a diagnosis and assess disease risk. Results also guide treatment planning at the time of diagnosis or relapse.

The procedure uses a local anaesthetic to numb the skin and surrounding tissue before the needle is inserted, so most patients feel pressure rather than sharp pain. You may experience mild soreness at the site for a day or two after the procedure. The process is generally well tolerated and completed in a short time.

Results for the MM test at Lupin Diagnostics are typically available within 3 days. The report is sent directly via email or WhatsApp once ready.

A positive result means the translocation between chromosomes 11 and 14 was detected in your sample. This is classified as a standard-risk finding in multiple myeloma under international guidelines, though overall prognosis depends on many additional factors. Your haematologist or oncologist will discuss the implications in the context of your complete clinical picture.

Yes, in many cases. The MYEOV/IgH (MM) test is recommended at the time of initial diagnosis and again if the disease relapses or progresses. Repeat testing helps doctors understand how the disease has changed and supports decisions about further treatment.

No, MM test home collection is not available. The test requires a bone marrow aspiration, which must be performed by a qualified medical professional in a clinical setting. You will need to visit a Lupin Diagnostics centre for sample collection.