MTB Susceptibility – Kanamycin Test: Booking, Price, and Results
About MTB Susceptibility – Kanamycin Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Antibiogram – MTB (Kanamycin), AFB Susceptibility – Kanamycin, TB Drug Susceptibility Test – Kanamycin, Kanamycin Sensitivity Test for TB |
| Sample Type | Ascitic fluid, aspirate, BAL, bile, bone marrow, bronchial fluid, catheter tip, corneal scraping, CSF, endotracheal secretion, gastric fluid, hair clipping, liver abscess fluid, nail, pericardial fluid, peritoneal fluid, pleural fluid, pus swab, reproductive tract secretions, semen, skin scraping, sputum, swab, synovial fluid, throat swab, tissue, urine, vaginal fluid, vaginal swab, pure culture, pus |
| Fasting Required | No |
| Report Time | 29 days |
| Recommended For | All genders and ages; primarily patients with diagnosed or suspected drug-resistant TB |
| Price | Starting at ₹2,200 |
What Is an MTB Susceptibility – Kanamycin Test?
The MTB Susceptibility – Kanamycin test checks whether the bacteria causing a tuberculosis (TB) infection respond to the antibiotic kanamycin. It is ordered when a patient has confirmed TB and the treating doctor needs to know which drugs will work. The test is also known as the Antibiogram – MTB (Kanamycin) or the Kanamycin Sensitivity Test for TB. A pure culture grown from the patient's sample is used to carry out the test.
What Does an MTB Susceptibility – Kanamycin Test Measure?
This test measures whether Mycobacterium tuberculosis (MTB), the bacterium responsible for TB, is sensitive to or resistant to kanamycin. Kanamycin belongs to the aminoglycoside class of antibiotics, a group of medicines that work by stopping bacteria from making proteins. It is a second-line drug, meaning it is used when first-line TB medicines are no longer effective. The result guides the doctor in selecting the right combination of drugs. The table below summarises what the test assesses:
| Parameter | Possible Result | What It Means |
|---|---|---|
| MTB Susceptibility to Kanamycin | Sensitive | The bacteria respond to kanamycin; the drug can be used in treatment |
| MTB Susceptibility to Kanamycin | Resistant | The bacteria do not respond to kanamycin; an alternative drug is needed |
Why Is an MTB Susceptibility – Kanamycin Test Done?
This test is prescribed when there is a need to understand how a patient's TB bacteria respond to kanamycin. Below are the common reasons a doctor may order it.
Common Symptoms That May Require This Test
The following symptoms often prompt investigation into drug-resistant TB:
- Cough lasting more than three weeks
- Persistent fever and chills
- Night sweats
- Unexplained weight loss
- Loss of appetite
- Weakness or fatigue
- No improvement despite being on standard TB treatment
Conditions This Test Can Help Detect
The MTB Susceptibility – Kanamycin test can help identify the following conditions:
- Multidrug-resistant tuberculosis (MDR-TB), defined as resistance to at least isoniazid and rifampicin
- Extensively drug-resistant tuberculosis (XDR-TB), which involves resistance to rifampicin, isoniazid, a fluoroquinolone and at least one second-line injectable drug, such as kanamycin
- Pre-extensively drug-resistant TB (pre-XDR-TB), where the bacteria meet MDR-TB criteria and are also resistant to a fluoroquinolone or a second-line injectable agent
- Drug resistance in patients whose TB has not responded to standard treatment
MTB Susceptibility – Kanamycin Test for Chronic Disease Monitoring
Patients undergoing treatment for MDR-TB are typically monitored with cultures every month throughout the full course of therapy. The MTB Susceptibility – Kanamycin test helps the treating doctor track whether the treatment is working or whether the drug regimen needs to be changed. MDR-TB treatment can last anywhere from 9 to 20 months, making regular testing an important part of care.
How to Prepare and What to Expect
Preparing correctly helps ensure the sample collected is suitable for testing. The guidance below covers the key steps.
Do You Need to Fast?
No fasting is required before this test. You can eat and drink normally before your appointment.
Practical Tips Before Your Test
Keep the following points in mind before you go for sample collection:
- Bring a detailed clinical history, including your symptoms, previous test results and relevant medical records, along with your complete address and mobile number, as these are required for this test.
- Provide your full address and mobile number at the time of booking or registration.
- Inform your doctor about any anti-TB medicines or other antibiotics you are currently taking, as these can affect results.
- If providing a sputum sample, rinse your mouth thoroughly with water beforehand (do not use mouthwash).
- Collect sputum samples (if applicable) early in the morning, before eating or drinking.
- If three sputum specimens are needed, they should ideally be collected 8 to 24 hours apart.
- Ensure the sample reaches the laboratory within 24 hours of collection; refrigerate it if there is any delay in transport.
Step-by-Step Procedure
The process from sample collection to reporting follows these steps:
- Your doctor confirms the need for the MTB Susceptibility – Kanamycin test based on your clinical history and previous test results.
- The appropriate sample is collected, which may be sputum, BAL, CSF, pus, urine or another body fluid depending on the site of infection. Sputum samples should be collected in a well-ventilated, isolated area as a safety measure.
- The sample is placed in a sterile container and transported to the laboratory under refrigerated conditions (2 to 8 degrees Celsius) to maintain its quality.
- In the laboratory, MTB bacteria are cultured (grown) from the sample. This stage takes several days.
- Once a pure culture is available, it is tested against kanamycin at a defined concentration to determine sensitivity or resistance.
- Results are processed, and your report is made available within 29 days of sample receipt.
Factors That Can Affect Accuracy
Several factors may influence the reliability of the test result:
- Prior use of anti-TB medicines or antibiotics before sample collection
- Poor sample quality (for example, saliva rather than true sputum)
- Delays in transporting the sample to the laboratory
- Contamination of the sample during collection
- Improper storage temperature during transit
Understanding Your MTB Susceptibility – Kanamycin Test Results
Your result will be reported as either 'sensitive' or 'resistant'. A doctor familiar with your full medical history is best placed to explain what the finding means for your treatment. The table below provides general reference information.
| Parameter | Result | Interpretation |
|---|---|---|
| MTB Susceptibility to Kanamycin | Sensitive | TB bacteria respond to kanamycin; the drug may be included in the treatment plan |
| MTB Susceptibility to Kanamycin | Resistant | TB bacteria do not respond to kanamycin; the treatment regimen will need to be adjusted |
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain factors can make result interpretation more complex:
- A few days of anti-TB treatment taken before the sample is collected may slow bacterial growth in the laboratory, which can affect the ability to isolate MTB and complete susceptibility testing. If you have already started treatment, inform your doctor and the laboratory team.
- Detecting kanamycin resistance is technically more demanding than detecting resistance to first-line drugs, and results may take longer to confirm.
How to Maintain Healthy Levels
The following general wellness steps support TB treatment outcomes:
- Complete the full course of treatment as prescribed by your doctor, even if you start feeling better before it ends.
- Attend all follow-up appointments and monitoring tests as scheduled.
- Follow infection control measures recommended by your healthcare team to protect those around you.
- Maintain good nutrition and rest to support your immune system during treatment.
Lupin Diagnostics MTB Susceptibility – Kanamycin Test Price
The MTB Susceptibility – Kanamycin test is priced starting at ₹2,200 at Lupin Diagnostics. This test requires a visit to a Lupin Diagnostics centre; home collection is not available due to the specialised biosafety requirements for handling TB samples.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 2200 |
| CHENNAI | 2200 |
| HYDERABAD | 2200 |
| KOLKATA | 2200 |
| NAVI MUMBAI | 2200 |
| PUNE | 2200 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Booking your MTB Susceptibility – Kanamycin test online at Lupin Diagnostics is straightforward:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time for sample collection.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
The MTB Susceptibility – Kanamycin test checks whether the TB-causing bacteria in a patient's body respond to the antibiotic kanamycin. It helps doctors decide if kanamycin can be included in the treatment plan or whether a different drug is needed.
This test is recommended for patients who have not responded to standard TB treatment, those with TB resistant to first-line drugs like rifampicin, individuals who have been in contact with a known drug-resistant TB patient and patients whose culture remains positive after three or more months of treatment.
The test uses a pure culture grown from a range of samples including sputum, BAL, CSF, pus, urine, tissue or other body fluids, depending on where the infection is located. The most appropriate sample type will be advised by your doctor.
The report is available within 29 days. This is because the laboratory must first grow the bacteria from the sample, a process that takes time, before testing the culture against kanamycin.
A resistant result means the TB bacteria in your body will not respond to kanamycin. Your doctor will review the findings and adjust your treatment plan, selecting alternative second-line medicines that are likely to be effective.
No, home collection is not available for this test. Sample collection and TB culture work require specialised laboratory facilities with appropriate safety controls, so a centre visit is necessary.
Yes. You will need to provide a detailed clinical history, including your symptoms, previous test results and relevant medical records. A valid mobile number and complete address are also required at the time of registration.
MTB Susceptibility – Kanamycin Test: Booking, Price, and Results
