Maturity-Onset Diabetes of the Young (MODY) Gene Panel
About Maturity-Onset Diabetes of the Young (MODY) Gene Panel
| Field | Value |
|---|---|
| Also Known As | MODY Panel, Monogenic Diabetes Gene Panel, MODY Genetic Test, NGS MODY Panel |
| Sample Type | Chorionic Villus Sample (CVS), Amniotic Fluid, or Peripheral Blood |
| Fasting Required | No fasting required |
| Report Time | 35 days |
| Recommended For | Males and females; typically those with diabetes diagnosed before age 30 with a family history of the condition |
| Price | Starting at ₹21,600 |
What Is a Maturity-Onset Diabetes of the Young (MODY) Gene Panel?
The Maturity-Onset Diabetes of the Young (MODY) Gene Panel test is a specialised genetic test that examines a patient's DNA for mutations in genes linked to MODY, a rare inherited form of diabetes. It is prescribed when a doctor suspects that a patient's diabetes may have a genetic cause rather than being typical Type 1 or Type 2 diabetes.
Also known as the MODY Panel or Monogenic Diabetes Gene Panel, this test uses Next-Generation Sequencing (NGS) technology to analyse multiple genes in a single run.
What Does a Maturity-Onset Diabetes of the Young (MODY) Gene Panel Measure?
The MODY Genetic Test examines several genes that are known to affect how the pancreas produces and regulates insulin. Below are the key genes analysed in this panel.
| Gene | MODY Type | Role |
|---|---|---|
| HNF1A | MODY3 | Controls the development of insulin-producing cells in the pancreas |
| GCK | MODY2 | Encodes an enzyme (glucokinase) that helps the pancreas sense blood sugar levels |
| HNF4A | MODY1 | Regulates pancreatic development |
| HNF1B | MODY5 | Involved in pancreatic and kidney development |
| Other genes | Various | Includes PDX1, NEUROD1, INS, ABCC8, KCNJ11, BLK, CEL, APPL1, and others that influence insulin production and glucose metabolism |
Why Is a Maturity-Onset Diabetes of the Young (MODY) Gene Panel Done?
The NGS MODY Panel is ordered when a patient's clinical picture does not fit the standard pattern of Type 1 or Type 2 diabetes. A doctor may request this test based on specific symptoms or family history.
Common Symptoms That May Require This Test
The following symptoms, particularly when they appear in younger, non-obese individuals, may prompt a doctor to order this test:
- Frequent urination that cannot be explained by other causes
- Excessive thirst persisting throughout the day
- Unusual fatigue without a clear reason
- Blurred vision linked to elevated blood sugar
- Unexplained weight loss
- Recurrent skin infections
Conditions This Test Can Help Detect
This test helps a doctor identify or rule out several diabetes-related conditions:
- Maturity-onset diabetes of the young (MODY) in a symptomatic individual
- Neonatal diabetes (ND), a rare form of diabetes presenting in infancy
- Genetic carrier status in family members who have a history of MODY
- Misclassified diabetes, where a person has been labelled as Type 1 or Type 2 but may actually have MODY
How to Prepare and What to Expect
Because this is a genetic test that analyses DNA rather than blood sugar or other metabolic markers, the preparation is straightforward. The sample may be collected as chorionic villus material, amniotic fluid, or peripheral blood, depending on the clinical requirement advised by the doctor.
Do You Need to Fast?
No fasting is required before the MODY Gene Panel test. The test looks at your DNA, so food or drink does not affect the sample or results.
Practical Tips Before Your Test
The following steps will help ensure your sample is collected and processed correctly:
- Bring a detailed clinical history, including your symptoms, previous diabetes test results, and family history of diabetes, as this is required for the test
- Inform your doctor if you have had a recent blood transfusion or bone marrow transplant, as these can interfere with genetic results
- Share any existing test reports for blood glucose and HbA1c with the collecting technician
- Wear a loose-fitting top or clothing with sleeves that roll up easily for sample collection
Step-by-Step Procedure
Here is what you can expect during the sample collection process:
- The doctor or genetic counsellor will review your clinical history and confirm the test request
- The appropriate sample type is selected based on the clinical requirement — chorionic villus sample (CVS), amniotic fluid, or peripheral blood
- For CVS collection, the sample is collected in a sterile container by a qualified clinician using the appropriate procedure at a clinical facility
- For amniotic fluid collection, the sample is collected in a Falcon tube by a qualified clinician using the appropriate procedure under clinical supervision
- For peripheral blood collection, a trained phlebotomist collects the sample in an EDTA tube
- All samples are labelled clearly with patient details and collection information
- The sample is stored and transported under recommended conditions to the laboratory
- In the lab, DNA is extracted and analysed using Next-Generation Sequencing (NGS) technology
Factors That Can Affect Accuracy
A few factors can influence how accurately results are interpreted:
- Recent blood transfusions or bone marrow transplants can alter the DNA profile detected
- Mislabelled samples may lead to incorrect results
- Insufficient or incomplete clinical history provided with the sample can limit interpretation
- Rare genetic variants may have limited published data available at the time of reporting, affecting classification
Understanding Your Maturity-Onset Diabetes of the Young (MODY) Gene Panel Results
Results from this test do not come as numerical values. Instead, each genetic variant identified is classified into one of the categories below. A genetic counsellor or specialist doctor will walk you through your report.
| Classification | What It Means |
|---|---|
| Pathogenic | A disease-causing mutation has been confirmed |
| Likely Pathogenic | A mutation that very probably causes the condition has been found |
| Variant of Uncertain Significance (VUS) | A change in the gene was detected, but its clinical impact is not yet clear |
| Likely Benign | The variant found is probably not causing disease |
| Benign | The variant has no known clinical impact |
For reference, the following blood sugar values are typically seen in GCK-MODY (MODY2):
| Parameter | Typical Range in GCK-MODY | Unit |
|---|---|---|
| Fasting glucose | 5.4 to 8.3 | mmol/L |
| HbA1c | 5.8% to 7.6% (40 to 60 mmol/mol) | % |
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Managing Your Health After a MODY Diagnosis
If your results indicate a MODY mutation, the following general steps are useful to discuss with your doctor:
- Work with an endocrinologist to determine the most appropriate management approach based on your specific MODY subtype, as different subtypes respond differently to treatment options
- Keep regular follow-up appointments so that your blood sugar levels and overall health are monitored consistently
- Encourage first-degree family members (parents, siblings, and children) to consider genetic testing, since MODY is an inherited condition that can be passed down to children across generations.
Lupin Diagnostics Maturity-Onset Diabetes of the Young (MODY) Gene Panel Price
The MODY test cost at Lupin Diagnostics starts at ₹21,600. Chorionic villus and amniotic fluid samples must be collected by qualified clinicians under appropriate clinical conditions at a clinical facility and sent to Lupin Diagnostics. Home collection may be available only when the prescribed sample type is peripheral blood.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 21,600 |
| CHENNAI | 21,600 |
| HYDERABAD | 21,600 |
| KOLKATA | 21,600 |
| NAVI MUMBAI | 21,600 |
| PUNE | 21,600 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
The following steps explain how to book the MODY test online with Lupin Diagnostics:
- Select the Maturity-Onset Diabetes of the Young (MODY) Gene Panel on the Lupin Diagnostics website
- Choose your city and the nearest Lupin Diagnostics centre
- Consult your doctor or clinician regarding the appropriate sample type and collection procedure
- Submit the collected sample to Lupin Diagnostics as per the recommended sample handling requirements
- Receive your report via email or WhatsApp within 35 days of sample dispatch
Frequently Asked Questions
MODY is a group of inherited diabetes conditions caused by mutations in single genes that affect how the pancreas functions. Unlike Type 1 diabetes, MODY does not involve the immune system attacking insulin-producing cells. Unlike Type 2 diabetes, it is not related to obesity or insulin resistance. Patients with MODY often continue producing some insulin on their own.
This test is typically recommended for non-obese individuals who were diagnosed with diabetes before the age of 30 and have a strong family history of diabetes across multiple generations. It is also considered for those who test negative for typical Type 1 diabetes markers (such as pancreatic autoantibodies) yet still have elevated blood sugar.
The MODY test checks for an inherited genetic condition that can be evaluated at different stages of life. For adults, teenagers, or children, a standard peripheral blood draw in an EDTA tube is used. For expectant parents with a known family history of monogenic diabetes, doctors can perform early prenatal screening using an amniotic fluid sample (in a Falcon tube) or a chorionic villus sample (CVS) collected under strict clinical supervision.
The report for this test is delivered within 35 days. This extended turnaround time reflects the detailed nature of Next-Generation Sequencing analysis and the clinical review required to classify identified variants accurately.
A VUS means a change in a gene was detected, but there is currently not enough published scientific evidence to confirm whether it causes disease. Your doctor or genetic counsellor may recommend family studies or suggest re-evaluation at a later date as more research becomes available.
Yes. Once a MODY-causing mutation is identified in a patient, first-degree relatives can undergo targeted genetic testing to check whether they carry the same mutation. This can help diagnose or rule out MODY in family members who have diabetes or who may be at risk.
Yes. Detailed clinical history is required when submitting a sample for the MODY Gene Panel test. This information helps the laboratory team and genetic specialists interpret variants in the context of your specific health background, symptoms, and family history, leading to a more accurate and meaningful report.
Maturity-Onset Diabetes of the Young (MODY) Gene Panel
