IHC Marker – Langerin (CD 207) Test: Booking, Price, and Results
About IHC Marker – Langerin (CD 207) Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | CD207 Test, Langerin Immunostain Test, Langerin IHC Test, CD207 Immunohistochemistry Test |
| Sample Type | Formalin-fixed paraffin-embedded (FFPE) tissue block |
| Fasting Required | No |
| Report Time | 3 days |
| Recommended For | All ages and genders; typically ordered when Langerhans cell histiocytosis or related disorders are suspected |
| Price | Starting at ₹1,920 |
What is an IHC Marker – Langerin (CD 207) Test?
The IHC marker – langerin (CD 207) test is a specialised laboratory test that detects the langerin protein in tissue samples using a technique called immunohistochemistry (IHC). Langerin, also known as CD207, is a protein found almost exclusively on Langerhans cells, a type of immune cell present in the skin and other tissues. Doctors order this test when they suspect conditions such as Langerhans cell histiocytosis (LCH), a rare disorder involving abnormal growth of these immune cells. The test is also referred to as the CD207 test, langerin immunostain test, langerin IHC test, or CD207 immunohistochemistry test.
What Does an IHC Marker – Langerin (CD 207) Test Measure?
This test uses a laboratory technique called immunohistochemistry (IHC) to identify the Langerin protein within a tissue section. The technique applies specially designed antibodies that bind to the Langerin protein and produce a visible colour change under a microscope.
The test measures one parameter:
| Parameter | What It Indicates |
|---|---|
| Langerin (CD207) Expression | Whether Langerin protein is present (positive) or absent (negative) in the tissue sample |
Why is an IHC Marker – Langerin (CD 207) Test Done?
This test is ordered when a doctor suspects a condition involving abnormal Langerhans cells. It is used both for initial diagnosis and to differentiate between types of histiocytic disorders.
Common Symptoms That May Require This Test
Several symptoms may prompt a doctor to request the IHC marker – langerin (CD 207) test. These include:
- Skin rash involving a single lesion or widespread areas of skin
- Scaly papules, nodules, or plaques on the skin
- Small red spots (petechiae) or bloody, crusting lesions
- Chronic cough, shortness of breath, or chest pain
- Bone pain or soft tissue swelling
- Recurrent lung collapse (pneumothorax)
- Unexplained fever or weight loss
Conditions This Test Can Help Detect
This test helps identify a range of Langerhans cell-related conditions:
- Langerhans cell histiocytosis (LCH), a rare disorder in which Langerhans cells multiply abnormally; positive Langerin staining is required for a definitive diagnosis
- Indeterminate cell histiocytosis, a related disorder that is typically Langerin-negative, helping to distinguish it from LCH
- Other non-Langerhans cell histiocytic disorders, such as Erdheim-Chester disease or Rosai-Dorfman disease
- Non-histiocytic conditions when LCH was initially suspected but has been ruled out
How to Prepare and What to Expect
The CD 207 test procedure involves a tissue sample rather than a blood draw, so patient preparation is minimal. The steps below explain what to expect at each stage.
Do You Need to Fast?
No fasting is required. The test is performed on a tissue block obtained through a biopsy, so there are no dietary restrictions before the procedure. Always follow specific instructions provided by your doctor.
Practical Tips Before Your Test
Being prepared helps the process go smoothly. Keep the following points in mind:
- Bring a detailed clinical history including your symptoms, previous test results, and family history, as this is required for the test
- Carry the formalin-fixed paraffin-embedded (FFPE) tissue block from your earlier biopsy or surgery
- Attach the original pathology report from the initial tissue examination
- Provide relevant imaging reports and clinical notes for the pathologist
- Inform your doctor about any medications or supplements you are currently taking
Step-by-Step Procedure
The CD 207 test procedure follows a set sequence carried out in a pathology laboratory. Here is how the process works:
- A tissue sample is collected through a biopsy. Depending on the suspected condition, this may be a fine-needle aspiration, core-needle biopsy, or surgical biopsy, all performed in a clinical setting.
- The tissue is sent to the laboratory, where it is embedded in paraffin wax to preserve its structure and then cut into very thin slices.
- Specially designed antibodies that bind to the langerin protein are applied to the tissue slices. These antibodies are linked to a dye so they can be seen under a microscope.
- A pathologist examines the stained slides and assesses the pattern, colour, and intensity of the staining.
- The pathologist prepares a report stating whether langerin expression is positive or negative, along with any relevant observations.
- The completed report is made available within 3 days.
Factors That Can Affect Accuracy
Several factors may influence the quality of staining and the reliability of results. These include:
- Quality of tissue fixation at the time of biopsy
- Tissue processing and storage before testing
- Specificity of the antibody used in staining
- Technical aspects of the staining process
Understanding Your IHC Marker – Langerin (CD 207) Test Results
Results from this test are qualitative and must be interpreted by a qualified pathologist alongside the patient's clinical details and other investigations. The table below outlines what each result typically indicates:
| Result | Interpretation |
|---|---|
| Positive | Langerin (CD207) protein is detected in the tissue; supports a diagnosis of LCH or a Langerhans cell-related disorder |
| Negative | Langerin (CD207) protein is absent; helps rule out LCH in most cases and points towards non-Langerhans cell histiocytic conditions |
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
How to Maintain Healthy Levels
Because this is a diagnostic test rather than a routine screening tool, lifestyle changes do not alter its results. The following points are relevant after receiving your report:
- If diagnosed with LCH, attend all follow-up appointments as advised by your doctor
- Keep copies of your pathology reports and imaging records for reference at future consultations
- Discuss any new or returning symptoms with your doctor promptly, as early review is helpful in managing Langerhans cell disorders
Lupin Diagnostics IHC Marker – Langerin (CD 207) Test Price
The CD 207 test cost at Lupin Diagnostics starts at ₹1,920. This test requires a visit to a hospital; home collection is not available as the sample must be submitted as an FFPE tissue block obtained through a clinical procedure. The table below shows indicative prices across major cities:
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 1920 |
| CHENNAI | 1920 |
| HYDERABAD | 1920 |
| KOLKATA | 1920 |
| NAVI MUMBAI | 1920 |
| PUNE | 1920 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
The CD 207 test online booking process at Lupin Diagnostics is straightforward:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time to submit your FFPE tissue block along with your clinical history and pathology reports.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
The IHC marker – langerin (CD 207) test detects the langerin protein in tissue samples using immunohistochemistry. It is primarily used to diagnose Langerhans cell histiocytosis and to differentiate it from other histiocytic conditions that look similar under a microscope. The result helps pathologists confirm or rule out Langerhans cell-related disorders.
This test is typically ordered when a doctor suspects Langerhans cell histiocytosis (LCH) or a related histiocytic disorder based on a patient's symptoms, skin lesions, or imaging findings. A positive Langerin result is required to confirm an LCH diagnosis definitively.
No, CD 207 test home collection is not available. The test requires a formalin-fixed paraffin-embedded tissue block, which must be submitted directly at a Lupin Diagnostics centre. The block is typically obtained from a prior biopsy procedure performed at a hospital.
At Lupin Diagnostics, the report is generally ready within 3 days of the tissue block being received and processed. The test results are delivered via email or WhatsApp.
A positive result means the langerin protein was detected in the tissue. This finding, when combined with positive CD1a staining and clinical presentation, is consistent with Langerhans cell histiocytosis. Your doctor will interpret the result alongside all available clinical and imaging information.
You should consult the doctor who ordered the test in the first place. Depending on your symptoms and diagnosis, this may be a dermatologist, a haematologist, or an oncologist. For confirmed LCH, a haematologist or oncologist typically oversees further management.
IHC Marker – Langerin (CD 207) Test: Booking, Price, and Results
