HLADQA1 & HLADQB1 - Coeliac Disease Test: Booking, Price, and Results
About HLADQA1 & HLADQB1 - Coeliac Disease Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | HLA-DQ2/DQ8 Typing for Coeliac Disease, Coeliac Disease HLA-DQ Genotyping, HLA Typing for Gluten Sensitivity, Coeliac Gene Test |
| Sample Type | Peripheral blood (EDTA tube) |
| Fasting Required | No fasting required |
| Report Time | 15 days |
| Recommended For | All ages, both genders; especially first-degree relatives of coeliac disease patients |
| Price | Starting at ₹10,800 |
What is a HLADQA1 & HLADQB1 - Coeliac Disease Test?
The HLADQA1 & HLADQB1 - Coeliac Disease Test is a genetic blood test that checks for specific gene variants linked to coeliac disease, an autoimmune condition triggered by gluten. It identifies whether a person carries the HLA-DQ2 or HLA-DQ8 gene variants, which are present in nearly all individuals with coeliac disease. Also known as HLA-DQ2/DQ8 Typing or the Coeliac Gene Test, it is performed on a small blood sample collected in an EDTA tube.
What Does a HLADQA1 & HLADQB1 - Coeliac Disease Test Measure?
This test analyses two specific genes involved in immune system function. The results show whether certain high-risk gene combinations are present.
Here are the key components the test examines:
| Gene or Variant | What It Represents |
|---|---|
| HLA-DQA1 gene | Encodes the alpha chain of the HLA-DQ protein, which plays a role in immune responses |
| HLA-DQB1 gene | Encodes the beta chain of the same HLA-DQ protein |
| HLA-DQ2.5 heterodimer | A specific gene combination found in roughly 90% of coeliac disease patients |
| HLA-DQ8 heterodimer | A second gene combination is found in 5 to 10% of coeliac disease patients |
| HLA-DQ2.2 heterodimer | A less common variant also associated with an elevated risk of coeliac disease |
Why is a HLADQA1 & HLADQB1 - Coeliac Disease Test Done?
Doctors order this test to assess genetic risk for coeliac disease, particularly when antibody tests are inconclusive or when a patient has already started a gluten-free diet.
Common Symptoms That May Require This Test
A doctor may suggest this test if you experience any of the following symptoms:
- Chronic diarrhoea lasting several weeks or longer
- Persistent bloating and abdominal discomfort
- Unexplained fatigue, which may point to iron-deficiency anaemia
- Unintentional weight loss
- Recurring abdominal pain
- Dermatitis herpetiformis, an itchy, blistering skin rash associated with gluten sensitivity
- Chronic migraines without a clear cause
Conditions This Test Can Help Detect
The HLADQA1 & HLADQB1 - Coeliac Disease Test can help with identifying or evaluating the following:
- Coeliac disease, a chronic autoimmune condition in which gluten damages the small intestine
- Genetic risk in first-degree relatives (parents, siblings, and children) of people already diagnosed with coeliac disease
- Susceptibility in individuals with autoimmune conditions such as type 1 diabetes or thyroiditis
- Risk assessment in those with certain genetic conditions, including Down syndrome, Turner syndrome, and Williams syndrome
- Situations where a patient has already begun a gluten-free diet, making antibody tests unreliable
How to Prepare and What to Expect
No special preparation is needed for this test. Here is what to know before your appointment.
Do You Need to Fast?
No fasting is required. You can eat and drink as normal before the test. However, if your doctor has ordered additional tests alongside this one, some of those may require fasting, so check with your healthcare provider beforehand.
Practical Tips Before Your Test
Keep the following in mind to help ensure accurate results:
- Continue eating foods that contain gluten until a diagnosis is confirmed. Do not start a gluten-free diet before testing.
- Bring a detailed clinical history report, including your symptoms, previous test results, and any relevant family history, as this is required for the test.
- Inform your doctor of all medications and supplements you are currently taking.
- Wear clothing with easy access to your arm for blood collection.
- For home collection, ensure you are available at the scheduled time, and your address details are confirmed in advance.
Step-by-Step Procedure
Here is what happens during the HLADQA1 & HLADQB1 - Coeliac Disease Test procedure:
- A trained phlebotomist (blood collection specialist) will verify your identity and check your details.
- The collection site, usually the inside of your elbow, is cleaned with an antiseptic.
- A small blood sample of 2 ml is drawn from a vein and collected in a lavender-capped EDTA tube.
- The sample is labelled carefully and stored at the correct temperature (2 to 8 degrees Celsius) before dispatch.
- The sample is transported to the laboratory, where DNA is extracted from your blood cells.
- The DNA is analysed using MLPA (Multiplex Ligation-dependent Probe Amplification), a method that identifies the specific HLA gene variants associated with coeliac disease.
Factors That Can Affect Accuracy
The following factors may influence the reliability of your results:
- Incorrect patient identification at the time of sample collection
- Improper sample handling or storage during transport
- Rare genetic mutations at primer binding sites, which may cause diagnostic errors in exceptional cases
Understanding Your HLADQA1 & HLADQB1 - Coeliac Disease Test Results
Results from this test are qualitative, meaning they indicate whether specific gene variants are present and what level of risk they suggest. A doctor must interpret these findings in the context of your full clinical picture.
| Result | Risk Level |
|---|---|
| DQ2.5 homozygous (two copies of HLA-DQ2.5) | Very high risk (greater than 1 in 10) |
| DQ2.5 and DQ8 both present | High risk (greater than 1 in 20) |
| DQ8 homozygous (two copies of HLA-DQ8) | High risk (greater than 1 in 20) |
| DQ2.5 heterozygous (one copy of HLA-DQ2.5) | Intermediate risk (greater than 1 in 50) |
| DQ8 heterozygous (one copy of HLA-DQ8) | At risk (greater than 1 in 100) |
| Negative for both DQ2 and DQ8 | Not at risk |
A positive result does not confirm coeliac disease. These gene variants are present in approximately 30% of the general population, and only around 3% of those who carry them will go on to develop the condition. A negative result, on the other hand, makes coeliac disease very unlikely (lifetime risk below 0.04%).
Disclaimer: "These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice."
How to Maintain Healthy Levels
Genetic results cannot be changed, but the following steps are helpful regardless of your outcome:
- If your result shows a genetic risk, discuss a monitoring plan with a gastroenterologist.
- First-degree relatives of coeliac disease patients have a 4 to 15% chance of developing the condition, so family members may also benefit from screening.
- Maintain a balanced diet and seek medical advice if you have persistent digestive symptoms.
Lupin Diagnostics HLADQA1 & HLADQB1 - Coeliac Disease Test Price and Home Collection
The HLADQA1 & HLADQB1 - Coeliac Disease Test is available at Lupin Diagnostics starting at ₹10,800, with home sample collection offered across major cities.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 10800 |
| CHENNAI | 10800 |
| HYDERABAD | 10800 |
| KOLKATA | 10800 |
| NAVI MUMBAI | 10800 |
| PUNE | 10800 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Follow these steps to book your HLADQA1 & HLADQB1 - Coeliac Disease Test online:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Home Collection
HLADQA1 & HLADQB1 - Coeliac Disease Test home collection is available across cities through Lupin Diagnostics. A trained phlebotomist visits your home at the scheduled time to collect the blood sample. All samples are processed in NABL-accredited laboratories, and your digital report is shared directly with you once ready.
Frequently Asked Questions
This is a genetic test that checks for HLA-DQ2 and HLA-DQ8 gene variants associated with coeliac disease. The link between these gene variants and coeliac disease is one of the strongest known HLA-disease associations. The test helps assess genetic susceptibility rather than confirming an active diagnosis.
No. A positive result means you carry gene variants that increase the risk of coeliac disease, but it does not confirm the condition. These variants are found in about 30% of the general population, and only around 3% of those who carry them will develop coeliac disease. Further tests, such as antibody tests or an intestinal biopsy, are needed to confirm a diagnosis.
Yes. Because this is a genetic test, the results are not affected by your diet. This makes it particularly useful when a person has already started a gluten-free diet before testing, as antibody tests may give misleading results in that situation.
This test is recommended for people who have a first-degree relative with coeliac disease, those with symptoms such as chronic diarrhoea and unexplained fatigue, and individuals with autoimmune conditions like type 1 diabetes or autoimmune thyroid disease. People with genetic conditions such as Down syndrome or Turner syndrome may also benefit.
No fasting is required. You can eat and drink normally before the test. There are no dietary restrictions specific to this test.
The report is delivered within 15 days from the date of sample collection. This allows time for DNA extraction, genetic analysis, and result verification at the laboratory.
Yes, children of any age can have this test done, particularly if they have symptoms that suggest coeliac disease or if there is a known family history of the condition. A paediatrician or gastroenterologist can advise on whether testing is appropriate for a child.
HLADQA1 & HLADQB1 - Coeliac Disease Test: Booking, Price, and Results
