Histamine, 24 Hours Urine
Histamine, 24 Hours Urine
Histamine is a substance that is released from specialized cells known as mast cells when they become activated, often as a part of an immune response to allergies. This test measures the quantity of histamine in the urine. Mast cells are large cells found throughout the body's tissues, primarily in the skin, lining of the intestines and air passages, and the bone marrow.
Mast cells play a role in the body's normal response to injury as well as allergic reactions. Normally, histamine concentrations in the blood and urine are very low. However, significant increases can be observed in individuals experiencing severe allergic reactions (anaphylaxis) or those with a condition called mastocytosis (abnormal mast cell proliferation).
To check for the presence of increased histamine production in urine during anaphylaxis, it is recommended to undergo Histamine, 24 Hours Urine test as histamine and its primary metabolite, N-methylhistamine, are excreted in urine
Symptoms Of Anaphylaxis
Difficulty in breathing
Drop in blood pressure
Dizziness
Swelling of the face, throat, tongue, and/or eyes
Red patches and rashes
What Is Histamine, 24 Hours Urine Test Used For?
Histamine, 24 Hours Urine test is performed to:
Help confirm a diagnosis of anaphylaxis, mast cell activation or mastocytosis
Monitor the effectiveness of treatments and interventions aimed at managing severe allergy symptoms
Test preparation
No special preparation is required for this test
Interpretation of the Test Results
Test results can differ based on factors such as your age, gender, health history, and other variables.
Typically, normal results range from 0.006 - 0.131 milligram per 24 hours (mg/24 hours). If histamine levels are found to be elevated in a 24-hour urine sample, it may indicate anaphylaxis or mastocytosis
FAQs
How is the sample collected for the Histamine, 24 Hours Urine test?
To provide a urine sample for this test, you will need to collect all of your urine over a 24-hour period. Begin by emptying your bladder fully in the morning without collecting it. Remember to take note of the time. From then on, collect your urine each time you use the bathroom throughout the day. To complete the 24-hour collection, urinate into the container on the morning of the next day and make sure to note the precise time
What are the risks involved in the Histamine, 24 Hours Urine test sample collection?
Urine sample collection for Histamine, 24 Hours Urine test does not pose any risks
What is the turnaround time (TAT) for the result of a Histamine, 24 Hours Urine test?
The result of a Histamine, 24 Hours Urine test is usually available within 3-7 working days. However, this duration may vary depending upon the clinic
If I suspect that I have an allergy, is it advisable to undergo a histamine test?
To identify the allergens responsible for your allergies, your healthcare practitioner may prescribe specific allergy tests. However, a histamine test is usually reserved for cases where severe allergic symptoms, such as anaphylaxis, are observed. Many individuals with allergies will not require a histamine test
How is the collected urine stored during the 24-hour collection period?
Keep the collected urine in a cool and dark place such as a refrigerator until it is handed over to the laboratory
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