HBOC Extended Panel 155 gene: Booking, Price, and Results
About HBOC Extended Panel 155 gene: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Hereditary breast and ovarian cancer panel, HBOC gene panel, Comprehensive breast and ovarian cancer risk panel, BRCA and related genes panel, multigene hereditary cancer panel |
| Sample Type | Peripheral blood (venous) collected in an EDTA tube |
| Fasting Required | No fasting required |
| Report Time | 25 days |
| Recommended For | Adults of any gender with a personal or family history suggestive of hereditary breast and ovarian cancer syndrome |
| Price | Starting at ₹36,000 |
What Is an HBOC Extended Panel 155 Gene?
The HBOC Extended Panel is a genetic test that analyses genes associated with inherited breast, ovarian and related cancers. It looks for changes (mutations) in genes that may raise a person’s chance of getting cancer in the future. The test is done using advanced DNA-reading technology called next-generation sequencing (NGS), which can look at many genes accurately at the same time using a blood sample. Doctors prescribe this test when a person's personal or family history suggests a possible inherited predisposition to cancer. The sample required is a small quantity of peripheral blood, collected from a vein in the arm.
What Does an HBOC Extended Panel 155 Gene Measure?
This HBOC Extended Panel test examines multiple cancer susceptibility genes in a single run. The genes analysed include, but are not limited to, the following:
| Parameter (Genes) | What It Measures |
|---|---|
| BRCA1, BRCA2 | Help repair damaged DNA; mutations may raise breast and ovarian cancer risk |
| APC | Helps control cell growth; mutations may increase the risk of colorectal cancer |
| AKT1 | Involved in cell signalling; alterations may contribute to cancer development |
| ALK | Associated with certain types of cancers when changed |
| ATM, CHEK2, PALB2 | Involved in DNA repair; mutations raise breast and other cancer risks |
| RAD51C, RAD51D, BRIP1, BARD1 | Part of the same DNA repair pathway as BRCA1 and BRCA2 |
| MLH1, MSH2, MSH6, PMS2 | Mismatch repair genes that fix DNA copying errors; linked to Lynch syndrome |
| AIP, ANTXR1, ASCC1, ATR and others | Additional genes included in the extended panel with known or emerging links to hereditary cancer risk |
Why Is an HBOC Extended Panel 155 Gene Done?
This test is ordered when there is a clinical reason to investigate inherited cancer risk. Below are the common indications and the conditions the test can help identify.
Common Symptoms That May Require This Test
Doctors typically recommend this test based on personal or family history rather than symptoms alone. The following are the most common reasons for referral:
- Personal history of breast or ovarian cancer diagnosed at a young age
- Multiple family members affected by breast, ovarian, or related cancers
- Family history of male breast cancer
- Diagnosis of triple-negative breast cancer (a specific subtype)
- Family history of pancreatic or prostate cancer
- Ashkenazi Jewish ancestry, which carries a higher carrier frequency for BRCA mutations
Conditions This Test Can Help Detect
The HBOC Extended Panel can help identify inherited mutations associated with several conditions:
- Hereditary breast and ovarian cancer (HBOC) syndrome
- Familial adenomatous polyposis (FAP), caused by APC gene mutations (changed), which lead to multiple growths in the colon
- Lynch syndrome, a hereditary condition that raises the risk of colorectal and other cancers
- Li-Fraumeni syndrome is a rare inherited condition associated with multiple cancer types
- Other hereditary cancer predisposition syndromes
How to Prepare and What to Expect
No special physical preparation is required for this test. However, gathering the right documentation beforehand is essential for accurate results.
Do You Need to Fast?
No fasting is required before this test. You can eat and drink normally on the day of sample collection.
Practical Tips Before Your Test
The following steps will help ensure your sample is collected and processed correctly:
- Bring a detailed clinical history, including your symptoms, previous test results, and family history. This is required for the test.
- If this is a primary (first-time) cancer case, bring the histopathological report (tissue examination report) of the patient.
- Carry your doctor's prescription and any relevant earlier test reports.
- Prepare a written family history of cancers, including the type of cancer and age at diagnosis for each affected relative.
- Inform the laboratory if you have had a recent blood transfusion or bone marrow transplant, as this may affect results.
- Genetic counselling before the test is strongly advisable to help you understand what the results may or may not tell you.
Step-by-Step Procedure
Here is what to expect during sample collection for the HBOC Extended Panel test 155 gene:
- A trained phlebotomist (blood collection specialist) will confirm your identity and review the clinical documents you have brought.
- A small volume of blood (2 ml) is drawn from a vein in your arm using a fine needle.
- The blood is collected into a lavender-top EDTA tube, which prevents the blood from clotting during transit.
- The sample is labelled with your details and the date of collection.
- The sample is refrigerated and dispatched to the laboratory as soon as possible after collection.
- At the laboratory, the DNA is extracted from your blood and analysed using next-generation sequencing (NGS) technology.
Factors That Can Affect Accuracy
Certain conditions may affect the quality of results:
- Poor sample quality due to improper collection or delayed transport
- A recent blood transfusion, which may introduce donor DNA into the sample
- A recent allogeneic bone marrow or stem cell transplant, as the blood would carry the donor's DNA rather than the patient's
- Active blood cancers or haematological diseases, which may complicate NGS interpretation
- Incomplete or missing clinical history at the time of submission
Understanding Your HBOC Extended Panel 155 Gene Results
Results from this test are not straightforward numbers; they are classifications of genetic variants found in the tested genes. A qualified genetic counsellor or specialist doctor should always review these results alongside your clinical and family history.
| Parameter | References/ interpretations |
|---|---|
| Pathogenic (Class 5) | A disease-causing mutation has been identified |
| Likely Pathogenic (Class 4) | A probable disease-causing variant; associated with increased cancer risk |
| Variant of Uncertain Significance (VUS) (Class 3) | Insufficient evidence to confirm disease association |
| Likely Benign(Class 2) | Probably not disease-causing |
| Benign(Class 1) | Not associated with increased cancer risk |
These interpretations are general. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain medical situations can affect how results are interpreted. Here is one example.
Suppose you have an active blood cancer. DNA extracted from your blood may include mutations from the diseased tissue rather than inherited germline mutations, making interpretation more complex.
How to Maintain Healthy Levels
Genetic test results do not change with lifestyle, but these habits support general health and may reduce modifiable cancer risk:
- Maintain a balanced diet rich in vegetables, whole grains, and lean proteins, and keep a healthy body weight.
- Engage in regular physical activity, as exercise is associated with reduced cancer risk in the general population.
- Discuss a personalised cancer screening schedule with your doctor, based on your individual genetic profile and family history
Lupin Diagnostics HBOC Extended Panel 155 gene Price and Home Collection
The HBOC Extended Panel is available at Lupin Diagnostics starting at ₹36,000, with home blood collection available across major cities.
| City | Approximate price(₹) |
|---|---|
| Mumbai | 36000 |
| Pune | 36000 |
| Bangalore | 36000 |
| Chennai | 36000 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the HBOC Extended Panel test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Home Collection
Home collection for the HBOC Extended Panel is available across cities. A certified phlebotomist visits your home to collect the blood sample, which is then dispatched to a NABL-accredited Lupin Diagnostics laboratory for NGS analysis. Your digital report is shared with you once the results are ready.
Frequently Asked Questions
The HBOC Extended Panel is a genetic test that uses next-generation sequencing technology to analyse genes associated with hereditary breast, ovarian, and related cancers. It identifies inherited mutations that may raise a person's lifetime risk of developing certain cancers.
This test is recommended for individuals with a personal or family history suggestive of hereditary breast and ovarian cancer syndrome. It is also advised for those with Ashkenazi Jewish ancestry to have a family history of cancer.
A VUS does not confirm or rule out a genetic diagnosis. Scientific evidence for many variants is still developing, and your doctor may recommend re-evaluation at a later date if new research reclassifies the variant. Continue with regular health check-ups as advised.
The report for the HBOC Extended Panel 155 gene is delivered within 25 days of sample collection. In some cases, depending on the complexity of variants identified, it may take slightly longer.
This is a one-time genetic test. However, if your initial result includes a VUS, your doctor may recommend reclassification review in the future as more research becomes available.
No. A negative result means no known mutations were found in the genes tested. It does not eliminate all cancer risk, as most breast cancers are not caused by inherited mutations, and other genetic or environmental factors may still play a role.
HBOC Extended Panel 155 gene: Booking, Price, and Results
