HBOC Extended Panel 32 Gene Test: Booking, Price, and Results
About HBOC Extended Panel 32 Gene Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Hereditary breast and ovarian cancer panel, HBOC 32-gene panel, BRCA and related genes panel, Multigene hereditary cancer panel |
| Sample Type | Peripheral blood (EDTA tube) |
| Fasting Required | No fasting required |
| Report Time | 30 days |
| Recommended For | Adults (male and female) with a personal or family history of breast, ovarian, pancreatic, or prostate cancer; individuals of Ashkenazi Jewish ancestry |
| Price | Starting at ₹24,000 |
What is an HBOC Extended Panel 32 Gene Test?
The HBOC extended panel 32-gene test is a genetic blood test that checks for inherited mutations in 32 genes linked to hereditary breast and ovarian cancer. A small blood sample is collected and analysed using Next-Generation Sequencing (NGS), a technology that reads DNA in great detail. Doctors typically recommend this test for people with a personal or family history of certain cancers, or when a basic BRCA1/BRCA2 test has already returned a negative result despite a strong family history.
What Does an HBOC Extended Panel 32 Gene Test Measure?
The HBOC extended panel 32-gene test procedure involves analysing DNA extracted from a blood sample to identify harmful changes in genes associated with hereditary cancer risk. The genes are grouped by the level of risk they carry.
The panel covers two main categories of genes:
High-penetrance genes (associated with a significantly increased cancer risk):
| Parameter (Genes) | What It Measures |
|---|---|
| BRCA1 | Breast and ovarian cancer |
| BRCA2 | Breast, ovarian, prostate, and pancreatic cancer |
| CDH1 | Breast and stomach cancer |
| PALB2 | Breast and pancreatic cancer |
| PTEN | Breast and other cancers (Cowden syndrome) |
| STK11 | Multiple cancers (Peutz-Jeghers syndrome-stomach/intestinal growths with cancer risk) |
| TP53 | Multiple cancers (Li-Fraumeni syndrome- different cancers at a young age) |
Moderate-penetrance genes (associated with a moderately increased cancer risk):
| Parameter (Genes) | What It Measures |
|---|---|
| ATM | Breast and pancreatic cancer |
| BARD1 | Breast cancer |
| BRIP1 | Ovarian cancer |
| CHEK2 | Breast and colorectal cancer |
| MLH1, MSH2, MSH6, PMS2, EPCAM | Lynch syndrome-related cancers (Inherited multiple organ cancers) |
| NF1 | Breast and other cancers |
| RAD51C, RAD51D | Ovarian cancer |
Why is an HBOC Extended Panel 32 Gene Test Done?
This test is ordered when a doctor suspects an inherited cancer risk based on personal or family medical history. It helps identify whether a genetic mutation is contributing to that risk.
Common Symptoms That May Require This Test
The test is not based on symptoms in the traditional sense. Instead, it is recommended based on specific personal or family history factors. The following situations may lead a doctor to recommend testing:
- Personal diagnosis of breast cancer before age 50
- Personal history of ovarian, fallopian tube, or peritoneal cancer
- Multiple close relatives with breast or ovarian cancer
- A family member with male breast cancer
- Previous negative BRCA1/BRCA2 test result, but a strong family history of cancer remains
- Triple-negative breast cancer diagnosis
- Ashkenazi Jewish ancestry combined with a family history of breast or ovarian cancer
Conditions This Test Can Help Detect
The HBOC extended panel 32-gene test can help identify genetic predispositions to the following conditions:
- Hereditary breast and ovarian cancer (HBOC) syndrome
- Increased risk for prostate and pancreatic cancers
- Male breast cancer risk
- Lynch syndrome (related to MLH1, MSH2, MSH6, PMS2 genes)
- Li-Fraumeni syndrome (related to TP53 mutations)
- Cowden syndrome (related to PTEN mutations)
How to Prepare and What to Expect
Preparing for the HBOC extended panel 32-gene test involves a few practical steps to ensure accurate results and a smooth experience.
Do You Need to Fast?
No fasting is required for this test. You can eat and drink normally before your appointment.
Practical Tips Before Your Test
Here are a few things to arrange before you come in for sample collection:
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test
- Document your family's cancer history across at least three generations if possible
- Bring any previous genetic testing reports you may have
- Consider attending a pre-test genetic counselling session to understand what the results may mean for you and your family
- Inform the counsellor about your ancestry or ethnicity, as certain mutations are more common in specific populations
Step-by-Step Procedure
The following steps describe what happens from the time you arrive to when your sample is dispatched:
- You provide your clinical history and any relevant family cancer records to the healthcare team.
- A trained phlebotomist cleans a small area on your arm, usually the inside of the elbow.
- A small blood sample of 2 ml is drawn into an EDTA (lavender-top) tube.
- The sample is labelled and stored at 2 to 8 degrees Celsius for transport to the laboratory.
- In the lab, DNA is extracted from the blood and analysed across all 32 genes using Next-Generation Sequencing (NGS).
- Results are reviewed by a specialist, and your report is prepared, typically within 30 days.
Factors That Can Affect Accuracy
The following factors may affect the quality or interpretation of your results:
- Poor sample quality or improper storage during transport
- Incomplete or inaccurate family history information
- Certain rare gene variants that current sequencing technology may not detect
- Laboratory sequencing coverage and interpretation expertise
Understanding Your HBOC Extended Panel 32 Genes Test Results
Results from this test fall into three broad categories. A specialist, ideally a genetic counsellor or oncologist, should always review and explain your results in the context of your personal and family history.
| Parameter | Reference/ Interpretation |
|---|---|
| Pathogenic or Likely Pathogenic Variant (Positive) | A harmful change in one or more genes was detected; increased cancer risk is indicated |
| Variant of Uncertain Significance (VUS) | Insufficient evidence to confirm disease association |
| No Variant Detected (Negative) | No harmful mutation was identified in the 32 genes tested; some inherited risk may still exist based on family history |
These interpretations are general. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain medical situations can affect how results are interpreted.
If you have recently had a bone marrow or stem cell transplant, the blood sample will predominantly carry your donor's DNA. In such cases, the test should be an alternative sample type discussed with your doctor.
How to Maintain Healthy Levels
While genetic mutations cannot be changed, certain lifestyle habits can support overall health, particularly for those with a positive result:
- Maintain a healthy body weight and engage in regular physical activity, as these are associated with lower cancer risk.
- Limit alcohol intake, as excessive consumption has been linked to increased breast cancer risk.
- Follow the cancer screening schedule recommended by your doctor, particularly if you carry a pathogenic variant.
Lupin Diagnostics HBOC Extended Panel 32 Gene Test Price and Home Collection
The HBOC extended panel 32-gene test is available at Lupin Diagnostics, starting at ₹24,000, with home sample collection available across cities.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 24000 |
| CHENNAI | 24000 |
| HYDERABAD | 24000 |
| KOLKATA | 24000 |
| NAVI MUMBAI | 24000 |
| PUNE | 24000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
The following steps explain how to book the HBOC extended panel 32 genes test online:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified blood collector, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Home Collection
Lupin Diagnostics offers home collection for the HBOC extended panel 32 genes test across multiple cities in India. Your sample is collected by a trained phlebotomist and processed in NABL-accredited laboratories. Digital reports are shared via email or WhatsApp once ready.
Frequently Asked Questions
This test is recommended for individuals with a personal history of breast, ovarian, pancreatic, or prostate cancer, or those with multiple close relatives affected by these cancers. People with a relevant family history may also be advised to consider testing.
A positive result means a harmful change was found in one or more of the tested genes, indicating an increased risk of developing certain cancers. It does not mean you will definitely develop cancer. Your doctor will discuss appropriate screening, monitoring, or preventive options based on your specific result.
Yes. Men can inherit and carry a mutation. Male carriers may have an increased risk for prostate cancer, pancreatic cancer, and male breast cancer.
Results are typically available within 30 days.
Genetic counselling before and after testing is strongly recommended. Pre-test counselling helps you understand what the test can and cannot tell you, while post-test counselling helps you make sense of the results and decide on next steps.
A harmful mutation in genes can be passed on to children and siblings. Each first-degree relative (parent, sibling, or child) has roughly a 50% chance of carrying the same variant. It is advisable for close family members to speak with a genetic counsellor about whether testing is right for them.
HBOC Extended Panel 32 Gene Test: Booking, Price, and Results
