Gliadin Antibody (DGP), IgG Test: Booking, Price, and Results
About Gliadin Antibody (DGP), IgG Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Deamidated Gliadin Peptide (DGP) Antibody IgG Test, Anti-DGP IgG Test, DGP-IgG Test, Gliadin IgG Antibodies Test, Anti-Gliadin IgG Test |
| Sample Type | Serum (venous blood) |
| Fasting Required | No fasting required |
| Report Time | 4 days |
| Recommended For | All ages and genders; particularly useful for children under 2 years and individuals with IgA deficiency |
| Price | Starting at ₹1,600 |
What is a Gliadin Antibody (DGP), IgG Test?
The gliadin antibody (DGP), IgG test measures a specific type of antibody in the blood that the immune system produces in response to gluten. Gluten is a protein found in wheat, barley, and rye. Doctors order it when they suspect coeliac disease or gluten sensitivity, particularly in patients who cannot be assessed using standard IgA-based tests. This test is also known as the deamidated gliadin peptide (DGP) antibody IgG test, anti-DGP IgG test, DGP-IgG test, gliadin IgG antibodies test, or anti-gliadin IgG test. A small blood sample drawn from a vein is all that is needed.
What Does a Gliadin Antibody (DGP), IgG Test Measure?
This test measures a single type of antibody in the blood. The table below explains what it represents:
| Parameter | What It Measures |
|---|---|
| DGP IgG Antibodies | Immunoglobulin G antibodies directed against deamidated gliadin peptides; elevated levels point towards coeliac disease or gluten-related intestinal damage |
Coeliac disease is an autoimmune condition where the body reacts to gliadin by attacking the lining of the small intestine. This damages the tiny finger-like projections (villi) responsible for nutrient absorption, leading to significant nutritional deficiencies over time.
Why is a Gliadin Antibody (DGP), IgG Test Done?
A doctor may order this test for several reasons, ranging from evaluating new symptoms to tracking how well a patient is responding to dietary changes.
Common Symptoms That May Require This Test
The following symptoms are among the most common reasons a doctor may request this test:
- Persistent diarrhoea or loose stools
- Abdominal pain and bloating
- Excessive wind and indigestion
- Unexplained fatigue or weakness
- Unintended weight loss
- Constipation or nausea and vomiting
- An itchy skin rash or numbness and swelling in the hands and feet
Conditions This Test Can Help Detect
This test can support the evaluation of several conditions related to gluten exposure. These include:
- Coeliac disease, an autoimmune condition triggered by gluten
- Non-coeliac gluten sensitivity, especially in patients with IgA deficiency
- Dermatitis herpetiformis, a skin condition linked to gluten sensitivity
- Monitoring dietary adherence and treatment response in known coeliac disease
- Assessment in children under two years of age, where other coeliac markers are less reliable
Gliadin Antibody (DGP), IgG Test for Chronic Disease Monitoring
Once a patient with coeliac disease begins a gluten-free diet, this test can be repeated to check how well the body is responding. Antibody levels may take up to one year to normalise after dietary changes are made. If levels remain high, it may suggest the patient is still consuming gluten or has a form of coeliac disease that does not respond to diet alone. A fall in antibody levels generally indicates good adherence to a gluten-free diet.
How to Prepare and What to Expect
Preparing correctly for this test is essential to getting an accurate result. The most important step is to keep eating gluten-containing foods before the test.
Do You Need to Fast?
No fasting is required for this test. You must continue eating foods that contain gluten for at least 6 weeks before the test. If you have already stopped eating gluten, your antibody levels may drop to normal even if coeliac disease is present, leading to a misleading result. Do not switch to a gluten-free diet before your sample is collected. Always follow any specific instructions provided by your doctor.
Practical Tips Before Your Test
Follow these steps to ensure your sample gives the most accurate result:
- Continue eating gluten-containing foods (such as bread, pasta, and wheat-based products) every day for several weeks before the test. Stopping gluten early can cause the antibody levels to drop, leading to a false-negative result.
- Do not switch to a gluten-free diet before your blood is collected.
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test.
- Inform your doctor about any medications or supplements you are currently taking, as some can affect results.
- Wear a short-sleeved shirt on the day of collection to make the blood draw easier.
Step-by-Step Procedure
Here is what to expect during the DGP test procedure:
- A trained phlebotomist will ask you to sit comfortably and verify your identity and test details.
- The inner part of your elbow or another suitable vein on your arm will be cleaned with an antiseptic wipe.
- A tourniquet (elastic band) is tied around your upper arm to make the veins more visible.
- Blood is drawn from the vein using a needle into a serum separator tube (SST gel tube).
- The tourniquet is removed, and a small cotton pad or bandage is placed over the puncture site.
- The sample is labelled and stored at the correct temperature before being sent to the laboratory for analysis using the EIA (enzyme immunoassay) method.
Factors That Can Affect Accuracy
Several factors can influence how reliable your test result is:
- Following a gluten-free diet before the test (can cause a falsely negative result if not followed)
- Presence of IgA deficiency, which is more common in people with coeliac disease
- Certain medications or supplements
- Concurrent autoimmune conditions
- Improper sample handling or delays in serum separation
Understanding Your Gliadin Antibody (DGP), IgG Test Results
Your results should always be reviewed with a qualified doctor who is familiar with your full health history. The table below shows commonly used reference ranges for this test:
| Result | Level (AU/mL) | General Interpretation |
|---|---|---|
| Negative | Less than 15 | Decreased likelihood of coeliac disease |
| Equivocal | 15 to 30 | Borderline; repeat testing or further investigation may be needed |
| Positive | Greater than 30 | Consistent with coeliac disease; further confirmation (such as biopsy) is typically required |
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain health conditions can change how results are read:
In people who produce sufficient total IgA, the tissue transglutaminase (tTG) IgA test is considered the most sensitive marker for coeliac disease. In those who are IgA deficient, the DGP IgG test is the preferred option.
Coeliac disease is also more common in people who have type 1 diabetes, Down's syndrome, or autoimmune thyroid disease, and results in these groups should be interpreted with that context in mind.
How to Maintain Healthy Levels
These general wellness tips may help, particularly for those already diagnosed with coeliac disease:
- Maintain strict adherence to a gluten-free diet as advised by your doctor.
- Work with a registered dietitian to ensure your diet remains nutritionally complete while avoiding gluten.
- Attend regular follow-up appointments and repeat testing as recommended so your doctor can track your response over time.
Lupin Diagnostics Gliadin Antibody (DGP), IgG Test Price and Home Collection
The DGP test cost at Lupin Diagnostics starts at ₹1,600, and home collection is available across cities in India. The table below provides a reference for pricing:
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 1700 |
| CHENNAI | 800 |
| HYDERABAD | 800 |
| KOLKATA | 1900 |
| NAVI MUMBAI | 1600 |
| PUNE | 1600 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
DGP test online booking at Lupin Diagnostics is simple and takes just a few steps:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Home Collection
DGP test home collection is available across major cities in India through Lupin Diagnostics. All samples are processed in NABL-accredited laboratories by experienced technologists. Once your report is ready, you can access it digitally via email or WhatsApp.
Frequently Asked Questions
The gliadin antibody (DGP), IgG test is used to help identify coeliac disease, an autoimmune condition where the immune system reacts abnormally to gluten. It is also used to detect related conditions such as dermatitis herpetiformis and gluten-sensitive enteropathy. Your doctor will recommend this test if you have symptoms that suggest gluten intolerance or a family history of coeliac disease.
This test is particularly useful for children under 2 years old and for individuals with IgA deficiency, as other coeliac markers may not work reliably in these groups. It is also ordered for anyone experiencing ongoing digestive symptoms, unexplained anaemia, or skin rashes that may be linked to gluten sensitivity.
No. A positive gliadin antibody (DGP), IgG test result strongly suggests coeliac disease, but a definitive diagnosis requires a duodenal biopsy to check for damage to the lining of the small intestine. Your doctor will guide you on whether a biopsy is needed.
When gluten is removed from the diet, DGP IgG antibody levels begin to fall. If you have already stopped eating gluten, your antibody levels may appear normal even if coeliac disease is present. Eating gluten regularly in the weeks leading up to the test ensures an accurate result.
A positive result is consistent with coeliac disease, but it is not a final diagnosis on its own. A duodenal biopsy, which examines a small piece of intestinal tissue, is typically needed to confirm the diagnosis. Your doctor will guide you on the next steps based on your full clinical picture.
Yes, DGP test home collection is available through Lupin Diagnostics. A trained phlebotomist will visit your home at a convenient time to collect the blood sample, which is then transported to an NABL-accredited laboratory for analysis.
The tTG IgA test is generally the first-choice marker for coeliac disease in people who produce normal levels of IgA. The DGP test is recommended when a person has low or absent IgA levels, making the tTG IgA test unreliable. Both tests are often used together to give a clearer picture, and your doctor will decide which combination is appropriate for you.
Gliadin Antibody (DGP), IgG Test: Booking, Price, and Results
