FISH - MDS Panel Test
About FISH - MDS Panel Test
| Field | Value |
|---|---|
| Also Known As | MDS FISH Panel, Myelodysplastic Syndrome FISH Panel, FISH for MDS, Cytogenetics FISH Panel for MDS |
| Sample Type | Bone marrow aspirate (preferred) or peripheral blood in a sodium heparin tube |
| Fasting Required | No |
| Report Time | 5 days |
| Recommended For | Adults of all ages, primarily older adults, both male and female |
| Price | Starting at ₹8,900 |
What is a FISH - MDS Panel Test?
The FISH - MDS Panel Test uses fluorescence in situ hybridisation (FISH), a laboratory technique that applies fluorescent probes to detect specific chromosomal changes in cells. It is prescribed to evaluate myelodysplastic syndromes (MDS), a group of blood disorders in which the bone marrow does not produce healthy blood cells. The test is also known as the MDS FISH Panel or Myelodysplastic Syndrome FISH Panel. A bone marrow aspirate or peripheral blood sample collected in a sodium heparin tube is used for the analysis.
What Does a FISH - MDS Panel Test Measure?
This panel examines cells for four key chromosomal abnormalities that are frequently associated with MDS. Each abnormality provides information about diagnosis, prognosis, and disease management.
The following chromosomal regions are analysed:
| Probe Target | What It Detects |
|---|---|
| del 5q31.2 | Deletion on chromosome 5; linked to a specific MDS subtype with a generally favourable outlook |
| del 7q22.1 and del 7q36.1 | Deletion or loss of chromosome 7; associated with a less favourable prognosis |
| Trisomy 8 | An extra copy of chromosome 8, a common chromosomal change in blood disorders |
| del 20q11 | Deletion on chromosome 20; observed in MDS and related myeloid conditions |
Why is a FISH - MDS Panel Test Done?
A doctor may request the FISH - MDS Panel Test when blood counts are unexplained or when a blood disorder is suspected. It plays a key role in confirming diagnosis, assessing risk, and guiding treatment decisions.
Common Symptoms That May Require This Test
Patients are often referred for this test when they present with one or more of the following symptoms:
- Persistent fatigue and weakness due to low red blood cell levels (anaemia)
- Unexplained breathlessness with minimal physical effort
- Frequent infections caused by a reduced white blood cell count
- Easy bruising or bleeding that seems out of proportion to minor injuries
- Flat, pinpoint red or purple spots on the skin (known as petechiae) caused by minor bleeding under the surface
- Unusual pallor or a consistently pale appearance
Conditions This Test Can Help Detect
This panel is used to identify and assess the following conditions:
- Myelodysplastic syndrome (MDS), including specific subtypes defined by chromosomal patterns
- Risk of transformation from MDS to acute myeloid leukaemia (AML)
- Other myeloid malignancies associated with recurrent chromosomal changes
- Prognosis and risk stratification in patients with known or suspected MDS
FISH - MDS Panel Test for Chronic Disease Monitoring
For patients already diagnosed with MDS, this test is used alongside conventional cytogenetics (chromosome analysis) to track the course of the condition. It helps identify known chromosomal abnormalities over time and can indicate how well a patient is responding to therapy. If the disease evolves or new chromosomal changes develop, repeat testing can capture these changes.
How to Prepare and What to Expect
The FISH - MDS Panel Test procedure involves bone marrow aspiration, which is carried out in a clinical setting by a trained healthcare professional. Knowing what to expect can help ease any anxiety before the appointment.
Do You Need to Fast?
No fasting is required before this test. You may eat and drink normally on the day of your appointment.
Practical Tips Before Your Test
Keep the following points in mind when preparing for the procedure:
- Bring a detailed clinical history, including your symptoms, previous test results, and relevant medical records, as this is required for the test
- Inform your doctor about all medications you are currently taking, particularly blood thinners or anticoagulants
- Discuss any known allergies, especially to local anaesthetics, with your healthcare provider in advance
- Wear comfortable, loose-fitting clothing on the day of the procedure for ease of access to the hip area
- Arrange for someone to accompany you, as you may feel mild discomfort after the procedure
Step-by-Step Procedure
The bone marrow sample for this test is collected through a procedure called bone marrow aspiration. Here is what typically happens:
- You will be asked to lie on your side or stomach so that the doctor can access the hip bone, the most common collection site.
- The skin over the area is cleaned thoroughly, and a local anaesthetic is injected to numb the skin and the surface of the bone.
- A specialised needle is inserted into the bone. A small syringe attached to the needle draws out a liquid bone marrow sample through gentle suction.
- The collected sample (approximately 3 ml) is placed into a green-top sodium heparin tube and inverted gently several times to prevent clotting.
- In some cases, a peripheral blood sample (also 3 ml in a green-top tube) may also be collected as an additional specimen.
- Both samples are stored at 2 to 8 degrees Celsius and dispatched to the NABL-accredited laboratory for FISH analysis.
Factors That Can Affect Accuracy
Several factors can influence the quality of results. These include:
- Clotted or insufficient bone marrow samples, which may reduce the number of cells available for analysis
- Samples older than 24 hours, as these are considered suboptimal for FISH testing
- Prior chemotherapy or radiation therapy, which can affect bone marrow cellularity
- Improper sample handling or delays in transport to the laboratory
- Patient positioning, site selection, and sampling technique during the procedure
Understanding Your FISH - MDS Panel Test Results
Results from the FISH - MDS Panel Test are reported per probe target and indicate whether a chromosomal abnormality was detected. A specialist will interpret your results alongside your clinical history, blood counts, and other investigations.
| Parameter | Normal Result | Interpretation If Abnormal |
|---|---|---|
| 5q deletion | Negative (no abnormal clone detected) | Deletion present; may indicate a specific MDS subtype |
| 7q deletion or Monosomy 7 | Negative (no abnormal clone detected) | Deletion or loss present; associated with poorer prognosis |
| Trisomy 8 | Negative (no abnormal clone detected) | An extra chromosome 8 is present, seen in various myeloid disorders |
| 20q deletion | Negative (no abnormal clone detected) | Deletion present; associated with MDS and myeloid conditions |
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
A negative result does not completely rule out a myeloid disorder. Some genetic changes may fall outside the regions targeted by the specific probes used in this panel.
If a satisfactory conventional chromosome analysis (karyotype with 20 interpretable metaphases) has already been obtained, the additional benefit of FISH testing is limited.
Prior chemotherapy or radiation therapy may also affect bone marrow cellularity and influence how results are read.
How to Maintain Healthy Levels
While chromosomal changes in MDS are not entirely preventable, the following general habits may support overall bone marrow health:
- Avoid prolonged exposure to benzene and other recognised carcinogenic chemicals in the environment or workplace
- Avoid smoking, as it is associated with an increased risk of haematological conditions
- Attend regular health check-ups, particularly if you have a history of chemotherapy, radiation therapy, or unexplained blood count changes
Lupin Diagnostics FISH - MDS Panel Test Price
The FISH - MDS Panel Test cost at Lupin Diagnostics starts at ₹8,900. This test requires a visit to a Lupin Diagnostics centre, as bone marrow sample collection must be performed by a trained healthcare professional in a clinical setting. Home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 8900 |
| CHENNAI | 8900 |
| HYDERABAD | 8900 |
| KOLKATA | 8900 |
| NAVI MUMBAI | 8900 |
| PUNE | 8900 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Booking the FISH - MDS Panel Test online at Lupin Diagnostics is straightforward:
- Select the FISH - MDS Panel Test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time for sample collection by a trained professional.
- Receive your report via email or WhatsApp within 5 days.
Frequently Asked Questions
The FISH - MDS Panel Test detects specific chromosomal abnormalities, such as deletions on chromosomes 5, 7, and 20, as well as trisomy 8, that are commonly associated with myelodysplastic syndromes (MDS). It helps doctors confirm a diagnosis, assess prognosis, and plan appropriate treatment.
The test primarily requires a bone marrow aspirate, which is collected from the hip bone under local anaesthesia. A peripheral blood sample in a sodium heparin tube may also be taken alongside it. Both collections are done by a trained healthcare professional at the centre.
You will receive a local anaesthetic to numb the skin and bone surface, which reduces discomfort significantly. You may feel brief pressure or a dull ache when the bone marrow is drawn out, as the inside of the bone cannot be fully numbed. Most patients find the procedure tolerable, and any discomfort usually passes quickly.
A negative result means no chromosomal abnormalities were found within the regions targeted by the panel probes. However, a negative result does not completely rule out MDS, as some genetic changes may not be picked up by the specific probes used. Your doctor will review the result alongside your other test findings.
The report is typically available within 5 days from the time the sample is received at the laboratory. Turnaround time may vary depending on sample quality and the complexity of the analysis.
This test is recommended for adults, particularly older individuals, who present with unexplained low blood cell counts, persistent fatigue, frequent infections, or unusual bleeding. It is also used for people already diagnosed with MDS to support risk assessment and monitor response to treatment.
Yes, you can book the FISH - MDS Panel Test online through the Lupin Diagnostics website. Select your preferred centre, choose a convenient appointment time, and visit the centre for sample collection. You will receive your results digitally once the analysis is complete.
FISH - MDS Panel Test
