FGFR1 Test: Booking, Price, and Results
About FGFR1 Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | FGFR1 FISH Test, FGFR1 amplification test, FGFR1 gene test, Fibroblast growth factor receptor 1 test |
| Sample Type | Bone marrow (sodium heparin tube) and peripheral blood (EDTA tube) |
| Fasting Required | No fasting required |
| Report Time | 8 days |
| Recommended For | Adults with suspected squamous cell carcinoma (lung, oesophagus, breast), myeloproliferative neoplasms with eosinophilia, or patients being evaluated for FGFR-targeted therapy eligibility |
| Price | Starting at ₹4,800 |
What is an FGFR1 Test?
The FGFR1 test detects changes in the FGFR1 gene, which provides instructions for making a protein called Fibroblast Growth Factor Receptor 1. This protein plays a key role in how cells grow and divide. When the gene is altered, cells may grow in an uncontrolled way, which can lead to certain cancers or inherited conditions.
The test is also known as the FGFR1 FISH test or FGFR1 amplification test. It uses a technique called FISH (fluorescence in situ hybridisation), which highlights specific gene sequences under a fluorescent microscope. Doctors order this test to guide treatment decisions, particularly when evaluating eligibility for targeted cancer therapies.
What Does an FGFR1 Test Measure?
The FGFR1 gene test analyses the FGFR1 gene for three types of changes that can affect how the gene behaves in cells.
| What is Detected | What it Means |
|---|---|
| FGFR1 gene amplification | Extra copies of the FGFR1 gene are present, which can drive abnormal cell growth in certain cancers |
| FGFR1 gene translocation or rearrangement | Part of chromosome 8 containing FGFR1 fuses with another chromosome region, causing abnormal protein activity |
| FGFR1 gene mutation | A change in the gene sequence that may affect how the receptor protein functions |
Why is an FGFR1 Test Done?
Doctors order the FGFR1 test when they need to understand the genetic makeup of a cancer or investigate certain inherited conditions.
Common Symptoms That May Require This Test
Several symptoms may prompt a doctor to request this test as part of a wider investigation:
- Unexplained weight loss
- Persistent cough or shortness of breath
- Haemoptysis (coughing up blood)
- Bone pain
- Eosinophilia (an elevated count of a type of white blood cell called eosinophils)
- Enlarged lymph nodes (lymphadenopathy)
- Signs or symptoms suggesting a hereditary syndrome affecting development
Conditions This Test Can Help Detect
The FGFR1 FISH test can help identify or confirm several conditions:
- Squamous cell carcinoma of the lung, breast, oesophagus, or thymus
- Squamous cell lung cancer (FGFR1 amplification occurs in approximately 20% of cases)
- Breast cancer (amplification is reported in approximately 10 to 15% of cases)
- 8p11 myeloproliferative syndrome, a rare condition that frequently involves eosinophilia
- Kallmann syndrome, a hereditary disorder affecting hormone production and the sense of smell
- Hartsfield syndrome, a rare condition involving abnormal brain development
- Pfeiffer syndrome, a genetic condition affecting skull bone fusion
How to Prepare and What to Expect
The FGFR1 test procedure involves collecting bone marrow and blood samples. No special preparation is needed, but a few steps will help the process go smoothly.
Do You Need to Fast?
No fasting is required before this test. You may eat and drink normally before sample collection.
Practical Tips Before Your Test
A few simple steps will help ensure your samples are collected safely and accurately:
- Bring a detailed clinical history, including your symptoms, previous test results, and family history, as this is required for the test
- Inform your doctor about all medications you are taking, especially blood thinners
- If possible, samples should be collected before chemotherapy is started, as treatment can affect results
- Wear clothing with easy access to the inner arm for blood collection
- Stay well hydrated before your appointment
Step-by-Step Procedure
The FGFR1 test requires two sample types: a bone marrow sample and a peripheral blood sample. Both are collected during the same appointment.
Bone Marrow Collection:
- A doctor cleans and numbs a small area, usually over the hip bone, with a local anaesthetic.
- A thin needle is carefully inserted into the bone marrow space to draw out approximately 3 ml of bone marrow.
- The sample is collected in a sodium heparin (green-top) tube and mixed gently.
- A small dressing is applied over the site after collection.
Peripheral Blood Collection:
- A trained phlebotomist cleans a vein in your arm and draws approximately 3 ml of blood into an EDTA (lavender-top) tube.
- Both samples are labelled, stored at 2 to 8 degrees Celsius, and dispatched to the laboratory for FISH analysis.
Factors That Can Affect Accuracy
Several factors can influence the reliability of your test result:
- Insufficient sample volume or poor sample quality
- Prior chemotherapy or other cancer treatments affecting cells
- Improper fixation or handling of samples before dispatch
- Delayed transport to the laboratory
- Inadequate tumour cell content in the sample
Understanding Your FGFR1 Test Results
Your results will be reported by a pathologist after analysing the FGFR1 gene under fluorescent microscopy. The table below explains the reference ranges used for interpretation.
| Parameter | Value | Interpretation |
|---|---|---|
| FGFR1 to CEN8 ratio | 2.0 or below | Negative (no amplification detected) |
| FGFR1 to CEN8 ratio | Above 2.0 | Positive (amplification present) |
| Average FGFR1 copies per nucleus | Fewer than 6 copies | Negative (no amplification detected) |
| Average FGFR1 copies per nucleus | 6 copies or more | Positive (amplification present) |
A negative result means no FGFR1 gene amplification, translocation, or pathogenic mutation was found. However, a negative result does not fully exclude the presence of a blood or tumour disorder. A positive result indicates that the FGFR1 gene is amplified or altered, which may have implications for cancer prognosis and treatment planning.
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
How to Maintain Healthy Levels
Because this is a genetic and molecular test, FGFR1 status cannot be altered through lifestyle changes. The following general points may still be helpful:
- Follow your oncologist's or specialist's guidance closely after receiving your results
- If a hereditary mutation is identified, consider genetic counselling to understand implications for you and your family
- Attend all scheduled follow-up appointments so your doctor can review results in the full context of your health
Lupin Diagnostics FGFR1 Test Price and Home Collection
The FGFR1 test cost at Lupin Diagnostics starts at ₹4,800. Home collection may be available for the blood sample component, while bone marrow sample collection must be performed at a hospital or authorised healthcare facility.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 4800 |
| CHENNAI | 4800 |
| HYDERABAD | 4800 |
| KOLKATA | 4800 |
| NAVI MUMBAI | 4800 |
| PUNE | 4800 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Follow these steps to book your FGFR1 test online:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection for peripheral blood samples through a certified phlebotomist. Bone marrow sample collection must be performed at a hospital or authorised healthcare facility by a trained specialist.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Home Collection
FGFR1 test home collection is available for peripheral blood samples across cities where Lupin Diagnostics operates. Bone marrow sample collection must be performed at a hospital or authorised healthcare facility by a trained specialist. All samples are processed in NABL-accredited laboratories by experienced pathologists and molecular specialists, and digital reports are delivered securely via email or WhatsApp once ready.
Frequently Asked Questions
The FGFR1 test is used to detect amplification, translocation, or mutation of the FGFR1 gene. It helps doctors predict disease outcomes and decide whether a patient may benefit from FGFR-targeted therapies, particularly in certain cancers of the lung, breast, and oesophagus.
At Lupin Diagnostics, the FGFR1 test procedure uses a method called FISH (fluorescence in situ hybridisation). This technique labels specific gene sequences with fluorescent markers and allows a pathologist to count gene copies and detect rearrangements under a microscope.
FGFR1 amplification has been found in squamous cell carcinoma of the lung, breast, oesophagus, and oral cavity, among other sites. It is also linked to 8p11 myeloproliferative syndrome, a rare and aggressive blood disorder.
A positive result means that extra copies or abnormal rearrangements of the FGFR1 gene were detected. This finding can serve as a biomarker to guide treatment and may indicate that the patient could be eligible for FGFR inhibitor therapy. Your treating doctor will explain the implications for your specific situation.
At Lupin Diagnostics, the report for the FGFR1 test is delivered within 8 days. This allows sufficient time for the FISH analysis and pathologist review to be completed accurately.
This is a super-specialised molecular test. It is typically ordered by an oncologist, haematologist, or geneticist based on clinical findings. Booking without a referral may not be appropriate; speak to your doctor first.
Coverage depends on your insurance provider and the terms of your policy. When the test is medically necessary for cancer diagnosis or treatment planning, some insurers may provide coverage. It is advisable to confirm with your insurer before booking.
FGFR1 Test: Booking, Price, and Results
