Everolimus Test: Booking, Price, and Results
About Everolimus Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Everolimus Level, Everolimus Drug Monitoring, Everolimus, Blood by LC-MS/MS, mTOR Inhibitor Level, Immunosuppressant Drug Level |
| Sample Type | Whole Blood (EDTA tube) |
| Fasting Required | No fasting required |
| Report Time | 5 days |
| Recommended For | Organ transplant recipients (kidney, liver, heart); patients on everolimus therapy for cancer or tuberous sclerosis complex |
| Price | Starting at ₹6,200 |
What is an Everolimus Test?
The Everolimus Test measures the concentration of the drug everolimus in your blood. Everolimus is an mTOR inhibitor, meaning it blocks a protein involved in cell growth and immune responses. Doctors use this test to check whether the drug level in your blood is within a safe and effective range. It is also known as the Everolimus Blood Test, Everolimus Level, or EVR.
What Does an Everolimus Test Measure?
This test analyses two key aspects of drug concentration in whole blood. The table below explains what is measured and why it matters.
| Parameter | What It Measures |
|---|---|
| Everolimus concentration | The total amount of everolimus present in your blood at the time of collection |
| Trough concentration (C0) | The lowest drug level in your blood, measured just before your next scheduled dose, gives the most reliable reading for dose adjustment |
Why is an Everolimus Test Done?
Doctors order this test whenever everolimus has been prescribed, to confirm the drug is working safely. Below are the main reasons it may be requested.
Common Symptoms That May Require This Test
The following signs may prompt your doctor to check your everolimus level:
- Fever or persistent fatigue, which may signal organ rejection or infection
- Unusual tiredness or general weakness
- Shortness of breath or a persistent cough
- Swelling of the hands, ankles, or feet
- Reduced urine output in kidney transplant patients
- Mouth ulcers, skin rash, or diarrhoea may indicate drug toxicity
- Poor response to treatment, where the drug does not appear to be working
- Suspected missed doses or changes in the medication schedule
Conditions This Test Can Help Detect
This test helps monitor and manage several conditions, including:
- Prevention of organ rejection following kidney, liver, or heart transplantation
- Advanced kidney cancer (renal cell carcinoma) and certain breast cancers
- Neuroendocrine tumours
- Subependymal giant cell astrocytoma (SEGA), a brain tumour linked to tuberous sclerosis complex
- Drug toxicity is due to the narrow gap between effective and harmful drug levels
Everolimus Test for Chronic Disease Monitoring
Everolimus has a narrow therapeutic range and significant variation in how the body absorbs and processes it from person to person. Because of this, routine therapeutic drug monitoring is recommended for all patients on this medication. Levels are typically checked weekly after starting or adjusting a dose, then monthly once stable levels are confirmed.
How to Prepare and What to Expect
Preparing correctly for your Everolimus Test helps ensure accurate results. Here is what you need to know before your sample is collected.
Do You Need to Fast?
No fasting is required for this test. You can eat and drink normally beforehand. However, the timing of your blood draw relative to your last dose is critical.
Practical Tips Before Your Test
Keep the following in mind to get the most accurate reading:
- Bring a detailed clinical history, including your symptoms, previous test results, and medication records, as this is required for the test
- Have your blood drawn immediately before your next scheduled everolimus dose (this is called the trough level)
- Record the exact date and time you took your last dose of everolimus
- Tell your doctor about all medicines you are currently taking, particularly antibiotics, antifungals, and anticonvulsants
- Avoid grapefruit and grapefruit juice for at least 24 hours before the test, as these can raise drug levels
- Avoid alcohol for 24 hours before the test
- Take everolimus consistently, either always with food or always without, as your doctor has instructed
Step-by-Step Procedure
- A soft elastic band is tied around your upper arm to make your veins easier to find. The skin over the puncture site is cleaned with an antiseptic solution.
- A trained phlebotomist inserts a sterile needle into a vein, usually in the inner elbow, and collects approximately 2 mL of blood into a lavender-top EDTA tube.
- The needle is removed, and a small dressing or cotton pad is pressed over the site to stop any minor bleeding.
- The blood sample is not centrifuged. It is kept as whole blood and stored at refrigerator temperature (2 to 8°C) until dispatch.
- The sample is sent to a NABL-accredited laboratory and analysed using EIA (enzyme immunoassay) to measure your everolimus concentration accurately.
- Your report is prepared and delivered within 5 days.
Factors That Can Affect Accuracy
Several factors can alter your test result. Be sure to discuss these with your doctor:
- Drug interactions, particularly with antibiotics, antifungals (such as ketoconazole), and anticonvulsants (such as carbamazepine or phenytoin)
- Incorrect collection timing, for example, drawing blood too soon after a dose rather than at the trough
- Missed or delayed doses before the test
- Consumption of grapefruit or grapefruit juice can raise drug levels significantly
- Liver function changes, as everolimus is metabolised primarily in the liver
- Genetic differences in how your body processes the drug
Understanding Your Everolimus Test Results
Your results should always be reviewed by your treating doctor alongside your clinical history, type of condition, and other medications. The table below shows the general therapeutic reference ranges.
| Parameter | Target Range | Unit | Notes |
|---|---|---|---|
| Everolimus (transplant, with calcineurin inhibitors) | 3 to 8 | ng/mL | Trough specimen required |
| Everolimus (transplant, without calcineurin inhibitors) | 6 to 10 | ng/mL | Trough specimen required |
| Everolimus (SEGA/Tuberous Sclerosis) | 5 to 15 | ng/mL | Trough specimen required |
| Critical value | 30 or above | ng/mL | Requires urgent clinical review |
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, type of transplant or condition, and other medications. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain conditions can affect how your body processes everolimus and therefore alter your results.
- Patients with liver (hepatic) impairment should be monitored especially closely, as reduced liver function slows everolimus metabolism and raises blood levels. Dose adjustments are often needed in this group.
- Everolimus is metabolised through the CYP3A4 enzyme pathway. Medicines that inhibit or activate this pathway, including ciclosporin, can raise or lower everolimus levels considerably, which is why a full medication review is important before each test.
How to Maintain Healthy Levels
These general tips support consistent and safe drug levels during treatment:
- Take your everolimus dose at the same time every day, without skipping, to keep blood levels steady
- Avoid grapefruit and grapefruit juice throughout your treatment, as they can push drug levels into a harmful range
- Attend all scheduled monitoring appointments so your doctor can adjust your dose promptly if needed
Lupin Diagnostics Everolimus Test Price and Home Collection
The Everolimus Test cost at Lupin Diagnostics starts at ₹6,200, and home collection is available across cities. The table below gives an approximate price guide based on available data.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 6200 |
| CHENNAI | 6200 |
| HYDERABAD | 6200 |
| KOLKATA | 6200 |
| NAVI MUMBAI | 6200 |
| PUNE | 6200 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the Everolimus Test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within 5 days.
Home Collection
Lupin Diagnostics offers home collection for the Everolimus Test across multiple cities, so you do not need to travel to a centre. All samples are processed in NABL-accredited laboratories. Your digital report is shared securely once ready.
Frequently Asked Questions
The Everolimus Test measures how much of the drug is present in your blood at a given time. Doctors use this information to confirm that levels are high enough to prevent organ rejection or treat a medical condition, but not so high that they cause toxicity. It is a key tool for safe and effective treatment management.
Blood should be collected immediately before your next scheduled dose, at what is called the trough point. This is when drug levels are at their lowest and give the most consistent, reliable reading. Make a note of when you took your last dose and share that information with the phlebotomist or laboratory.
Everolimus has a narrow therapeutic window, meaning the difference between an effective dose and a harmful one is small. It also behaves differently from person to person. Regular Everolimus Test monitoring allows your doctor to fine-tune your dose so you get the full benefit of the drug while minimising the risk of side effects.
No fasting is needed. You can eat and drink normally on the day of your test. The most important preparation step is timing your blood draw correctly, immediately before your next dose.
Several factors can alter your everolimus level reading. These include drug interactions with certain antibiotics, antifungals, or anticonvulsants, consuming grapefruit or grapefruit juice, missed doses, changes in liver function, and collecting the blood sample at the wrong time. Share a full list of your current medicines with your doctor before the test.
Monitoring frequency depends on your individual situation. After starting everolimus or changing your dose, levels are usually checked weekly until they stabilise. Once stable, monthly monitoring or testing as clinically indicated is typical. Your doctor will advise on the schedule that is right for you.
Yes. Lupin Diagnostics' home collection service is carried out by trained, certified phlebotomists following standardised procedures. Your sample is stored at the correct temperature and dispatched to a NABL-accredited laboratory for analysis, ensuring accurate and dependable results.
Everolimus Test: Booking, Price, and Results
