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Deletion 17p p53 (Multiple Myeloma, CLL) Blood/Bone Marrow Test: Booking, Price, and Results

About Deletion 17p p53 (Multiple Myeloma, CLL) Blood/Bone Marrow Test: Booking, Price, and Results

Field	Value
Also Known As	17p Deletion by FISH, del(17p) TP53, p53 Deletion FISH, TP53/17p13.1 Deletion
Sample Type	Peripheral blood (EDTA tube) or bone marrow aspirate (sodium heparin tube)
Fasting Required	No fasting required
Report Time	3 days
Recommended For	Adults of any gender with suspected or confirmed multiple myeloma, chronic lymphocytic leukaemia, or other blood cancers
Price	Starting at ₹5,000

What is a Deletion 17p p53 (Multiple Myeloma, CLL) Blood/Bone Marrow Test?

The Deletion 17p p53 Blood/Bone marrow test is a specialised genetic test that detects a specific chromosomal abnormality in cancer cells. It identifies whether the short arm of chromosome 17 (the 17p region) is missing, which removes a key tumour suppressor gene called TP53. Doctors typically order this test for patients with multiple myeloma (MM) or chronic lymphocytic leukaemia (CLL) to assess prognosis and guide treatment choices. It is also known as the 17p Deletion by FISH test, where FISH stands for fluorescence in situ hybridisation, a technique that uses fluorescent probes to detect genetic changes under a microscope.

What Does a Deletion 17p p53 (Multiple Myeloma, CLL) Blood/Bone Marrow Test Measure?

This test examines two key findings in the sample. The table below explains what each one means.

Parameter	What It Measures	Normal Finding
TP53 gene signals per cell	Number of copies of the TP53 gene present	2 signals per cell (both copies intact)
Percentage of cells with deletion	Proportion of cancer cells carrying the 17p deletion	Below the laboratory cut-off (typically less than 7 to 10%)

A higher percentage of cells carrying the deletion generally points to a more aggressive disease course and a reduced response to standard chemotherapy.

Why is a Deletion 17p p53 (Multiple Myeloma, CLL) Blood/Bone Marrow Test Done?

This test is ordered when a doctor needs to understand the genetic profile of a blood cancer. It helps predict how the disease may behave and informs decisions about treatment.

Common Symptoms That May Require This Test

A doctor may request this test when a patient presents with the following symptoms:

Unexplained and persistent fatigue
Swollen lymph nodes in the neck, armpits, or groin
Frequent infections that do not resolve easily
Unexplained weight loss
Persistent fever or night sweats
Easy bruising or unusual bleeding
Bone pain or repeated fractures (more common in multiple myeloma)

Conditions This Test Can Help Detect

This test is used in the diagnosis and risk assessment of several blood cancers. The conditions it can help identify or classify include:

Multiple myeloma, where del(17p) is found in roughly 10% of newly diagnosed patients and more frequently at relapse
Chronic lymphocytic leukaemia (CLL), where 17p deletion is present in 5 to 8% of patients needing first-line treatment and is linked to rapid disease progression
Acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS), where 17p changes carry prognostic significance

Deletion 17p p53 for Chronic Disease Monitoring

The Deletion 17p p53 Blood/Bone marrow test is not only done at diagnosis. It may be repeated at disease relapse or when a patient stops responding to treatment, as the deletion can be acquired during the disease course. In multiple myeloma, acquired del(17p) at relapse is associated with shorter progression-free survival. Repeat testing helps the oncologist adjust the treatment plan in a timely manner.

How to Prepare and What to Expect

There are no major preparation steps for this test, but a few important points apply. Read the guidance below before your appointment.

Do You Need to Fast?

No fasting is required for the Deletion 17p p53 Blood/Bone marrow test. You may eat and drink normally before your sample collection.

Practical Tips Before Your Test

Keep these points in mind before going for your test:

Bring a detailed clinical history including your symptoms, previous test results, and medical records, as this is required for the test.
Inform your doctor about any medications, supplements, or recent treatments such as chemotherapy, as these can affect cell viability.
Do not request collection in a lithium heparin tube, as this is not suitable for this test.
Wear clothing with easy access to the arm for a blood draw.
Samples must be refrigerated and transported with a cold pack; do not freeze them or place them directly on ice.

Step-by-Step Procedure

The Deletion 17p p53 test procedure involves two possible sample types. Your doctor will decide which one is appropriate.

Peripheral Blood Collection:

A healthcare professional will clean the skin over a vein in your arm.
A needle is inserted and 3 ml of blood is drawn into a lavender-top EDTA tube.
The sample is labelled, refrigerated, and sent to the laboratory with a cold pack.

Bone Marrow Aspirate Collection:

The procedure is performed in a clinical setting by a trained specialist.
The skin over the hip bone (or another suitable site) is cleaned and numbed with a local anaesthetic.
A needle is inserted into the bone marrow cavity and approximately 3 ml of aspirate is drawn into a green-top sodium heparin tube.
The sample is labelled and refrigerated immediately for transport.
In the laboratory, a fluorescent DNA probe specific to the 17p region is applied to cells spread on a glass slide.
Under a fluorescence microscope, at least 200 cells are examined to count TP53 gene signals and calculate the percentage of cells with a deletion.

Factors That Can Affect Accuracy

Several factors can influence the quality and reliability of results:

Poor sample freshness or low cell viability at the time of analysis
Use of an incorrect anticoagulant (sodium heparin is preferred for bone marrow)
Inadequate cell count in the sample
Improper storage or transport temperature
Previous chemotherapy, which may reduce the number of detectable cancer cells
Insufficient purification of plasma cells (CD138+ selection) in myeloma samples

Understanding Your Deletion 17p p53 (Multiple Myeloma, CLL) Blood/Bone Marrow Test Results

Results from this test are reported alongside the patient's clinical details and are best reviewed with an oncologist or haematologist. The table below outlines how findings are generally interpreted.

Finding	Interpretation
2 TP53 signals in majority of cells	No significant deletion detected (negative result)
1 or 0 signals in cells above the cut-off percentage	Deletion present (positive result); associated with high-risk disease
Deletion in less than 10% of cells (subclonal)	Lower-risk pattern; generally associated with better outcomes than a major clone
Deletion in more than 60% of cells	Major clone; associated with shorter progression-free survival

"These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice."

Results During Special Conditions

The proportion of affected cells matters. Patients with a deletion in a smaller percentage of cells tend to have better survival outcomes than those with the deletion in a larger proportion. Patients with subclonal del(17p) (10 to 60% of cells affected) generally show longer progression-free survival compared to those where more than 60% of cells carry the deletion. Previous chemotherapy may also reduce the pool of detectable cancer cells, which can influence the reported percentage.

How to Maintain Healthy Levels

This is a chromosomal genetic test, so lifestyle choices do not directly change whether the deletion is present. However, the following steps support overall disease management:

Attend all scheduled follow-up appointments with your haematologist or oncologist.
Discuss repeat testing at any sign of disease relapse or progression.
Maintain a balanced diet and adequate hydration to support general health during treatment.

Lupin Diagnostics Deletion 17p p53 (Multiple Myeloma, CLL) Blood/Bone Marrow Test Price

The Deletion 17p p53 Blood/Bone marrow test cost at Lupin Diagnostics starts at ₹5,000. This test requires a visit to a Lupin Diagnostics centre, as home collection is not available due to specialised sample handling requirements.

City	Approximate Price (₹)
BHOPAL	5000
CHENNAI	5000
HYDERABAD	5000
KOLKATA	5000
NAVI MUMBAI	5000
PUNE	5000

Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.

How to Book

Follow these steps to book the Deletion 17p p53 Blood/Bone marrow test online booking or in person:

Select the test on the Lupin Diagnostics website.
Choose your city and preferred centre location.
Visit the centre at your scheduled time for sample collection.
Receive your report via email or WhatsApp within 3 days.

Frequently Asked Questions

The Deletion 17p p53 Blood/Bone marrow test detects the loss of a region on chromosome 17 that contains the TP53 tumour suppressor gene. It is primarily used to assess prognosis and guide treatment decisions in patients with CLL and multiple myeloma.

For multiple myeloma, bone marrow is often preferred because the cancer cells (plasma cells) live in the bone marrow rather than the blood. A bone marrow sample gives a more accurate picture of how many cancer cells carry the deletion. For CLL, a peripheral blood sample is usually sufficient.

A positive result indicates high-risk disease that may respond poorly to standard chemotherapy. However, newer targeted therapies have shown benefit in patients with 17p deletion. Your doctor will discuss appropriate treatment options based on your full clinical picture.

The test is typically done at diagnosis. Repeat testing is recommended at disease relapse or if there are signs of progression, as the deletion can be acquired over time and was not necessarily present at the start.

A smaller proportion of affected cells (a subclonal deletion) is generally linked to better outcomes than having the deletion in the majority of cells. However, regular monitoring remains important, as subclones can grow over time.

A peripheral blood draw feels like a brief sting and is well tolerated. A bone marrow aspirate is more involved; the area is numbed with local anaesthetic beforehand, though some pressure or brief discomfort is normal. Your doctor's team will keep you comfortable throughout.

Yes. A negative result for 17p deletion does not rule out other chromosomal or molecular changes associated with high-risk disease. Your oncologist may recommend additional FISH tests or molecular panels to get a full genetic profile of the cancer.