del7q (Monosomy 7) by FISH Test: Booking, Price, and Results
About del7q (Monosomy 7) by FISH Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Monosomy 7 FISH, del(7q) FISH, Chromosome 7 Deletion FISH, 7q Deletion by FISH, -7/del(7q) FISH |
| Sample Type | Bone marrow aspirate (sodium heparin tube) and peripheral blood (EDTA tube) |
| Fasting Required | Not required for the FISH test itself; fasting may be needed if sedation is used during bone marrow collection |
| Report Time | 3 days |
| Recommended For | Adults and children of both genders with suspected myeloid malignancies |
| Price | Starting at ₹4,300 |
What is a del7q (Monosomy 7) by FISH Test?
The del7q (Monosomy 7) by FISH test is a specialised genetic test that checks for abnormalities on chromosome 7. It detects either a complete loss of chromosome 7 (monosomy 7) or a partial deletion of its long arm (del 7q). Doctors order this test when a patient shows signs of a myeloid blood disorder, such as myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). FISH stands for fluorescence in situ hybridisation, a laboratory technique that uses fluorescent probes to identify chromosomal changes.
What Does a del7q (Monosomy 7) by FISH Test Measure?
The del7q by FISH test analyses cells from a bone marrow or blood sample to detect specific chromosomal changes. Fluorescent probes target two regions on chromosome 7, namely 7q22 and 7q31.2, to identify deletions or loss of the chromosome.
The test looks for the following:
- Complete monosomy 7: Loss of the entire chromosome 7, leaving only one copy instead of the normal two
- Partial deletion del(7q): Loss of a portion of the long arm (q arm) of chromosome 7
- Unbalanced translocations: Structural rearrangements that result in loss of chromosome 7q material
- Signal pattern per cell: The number of fluorescent signals counted per nucleus, which indicates how many copies of chromosome 7 are present
Why Is a del7q (Monosomy 7) by FISH Test Done?
Doctors request this test to investigate blood disorders at a chromosomal level. It helps with diagnosis, prognosis, and treatment planning in patients with suspected or confirmed myeloid malignancies.
Common Symptoms That May Require This Test
A doctor may order the Monosomy 7 FISH test when a patient presents with the following symptoms:
- Persistent fatigue and unexplained weakness
- Frequent or recurring infections
- Unusual bruising or easy bleeding
- Shortness of breath without a clear cause
- Pallor (pale skin or pale appearance)
- Unexplained low blood cell counts on routine tests
Conditions This Test Can Help Detect
The del7q (Monosomy 7) by FISH test can help identify several serious blood-related conditions. These include:
- Myelodysplastic syndrome (MDS), a group of disorders where the bone marrow does not produce enough healthy blood cells
- Acute myeloid leukaemia (AML), a fast-growing cancer of the blood and bone marrow
- Therapy-related MDS or AML following previous chemotherapy with alkylating agents
- Juvenile myelomonocytic leukaemia and chronic myeloid leukaemia in children and adults
- MDS or AML arising in patients with inherited conditions such as Fanconi anaemia, Kostmann syndrome, and neurofibromatosis type 1
del7q (Monosomy 7) by FISH Test for Chronic Disease Monitoring
The del(7q) FISH test plays an important role in monitoring patients already diagnosed with MDS or AML. It complements conventional cytogenetics by assessing large numbers of both dividing and non-dividing cells. The test may be repeated to track treatment response, monitor disease progression, or assess minimal residual disease over time.
How to Prepare and What to Expect
Good preparation helps ensure the sample is collected safely and the results are accurate. Below is what you need to know before your appointment.
Do You Need to Fast?
Fasting is not required for the FISH test procedure itself. However, if your doctor uses sedation to manage discomfort during bone marrow aspiration, you may be asked to avoid food and drink from midnight the night before. Confirm fasting requirements with your doctor when your procedure is scheduled.
Practical Tips Before Your Test
Keep the following points in mind before attending your appointment:
- Bring a detailed clinical history including your symptoms, previous test results, and any relevant family history, as this is required for the test
- Tell your doctor about any bleeding disorders, such as haemophilia, before the procedure
- Disclose all current medications, particularly blood thinners (anticoagulants) and any vitamins or supplements
- Wear loose, comfortable clothing to allow easy access during sample collection
- Arrange for someone to take you home if you are receiving sedation
- Ensure the sample is delivered to the laboratory within 24 hours of collection, as delays can affect results
Step-by-Step Procedure
This test requires two samples: a bone marrow aspirate and a peripheral blood sample. Here is what to expect during collection.
Bone Marrow Sample:
- You will be positioned comfortably, and a local anaesthetic is applied to numb the area, usually the back of the hip bone
- A small needle is inserted to draw a liquid bone marrow sample into a sodium heparin (green-top) tube
- The procedure takes a few minutes; mild pressure or discomfort is normal and expected
- Once collected, the bone marrow sample is labelled and stored at 2 to 8 degrees Celsius for transport
Peripheral Blood Sample:
- A trained phlebotomist draws 3 ml of blood from a vein, usually in the arm, into a lavender-top EDTA tube
- Both samples are transported together to the laboratory, where FISH analysis is carried out using fluorescent probes targeting chromosome 7 regions
Factors That Can Affect Accuracy
The following factors may affect the reliability of your results:
- Delayed sample transport: samples must reach the laboratory within 24 hours of collection
- Frozen or clotted specimens, which are not acceptable for this test
- Sample stimulation with certain agents (such as PHA) before collection, which can mask cells with monosomy 7; unstimulated samples are preferred
- Low numbers of abnormal cells that fall below the laboratory's detection threshold
- Complex chromosomal rearrangements involving multiple abnormalities
Understanding Your del7q (Monosomy 7) by FISH Test Results
Results from this test are interpreted alongside other clinical investigations and cannot be read in isolation. The table below provides general reference information.
| Parameter | Normal Finding |
|---|---|
| Chromosome 7 copy number | 2 copies (two fluorescent signals per probe per cell) |
| Abnormal cell percentage | Below laboratory cutoff (typically below 5 to 10%) |
A positive result is reported when the percentage of cells showing an abnormality exceeds the laboratory's established cutoff. A negative result means no abnormality was detected, though it does not entirely rule out the presence of a blood disorder.
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain conditions can affect how results are interpreted:
- Samples stimulated with PHA or other agents before collection may conceal monosomy 7 cells, leading to an underestimate of the abnormal clone
- Complex karyotypes involving multiple chromosomal abnormalities may make signal counting and interpretation more difficult
- A very small abnormal cell population may fall below the detection threshold and produce a negative result even when an abnormality is present
How to Maintain Healthy Levels
This test detects chromosomal changes that cannot be prevented through lifestyle alone. General guidance includes:
- Attend all scheduled follow-up appointments with your haematologist (blood specialist) if you are undergoing treatment
- Avoid known environmental risks such as prolonged exposure to benzene and unnecessary ionising radiation
- Discuss any concerns about your treatment plan or disease monitoring with your specialist
Lupin Diagnostics del7q (Monosomy 7) by FISH Test Price
The del7q (Monosomy 7) by FISH test is priced starting at ₹4,300 at Lupin Diagnostics. This test requires a visit to a Lupin Diagnostics centre; home collection is not available for this test. The test is not scheduled on Sundays.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 4300 |
| CHENNAI | 4300 |
| HYDERABAD | 4300 |
| KOLKATA | 4300 |
| NAVI MUMBAI | 4300 |
| PUNE | 4300 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Follow these steps to book your del7q by FISH test online at Lupin Diagnostics:
- Select the test on the Lupin Diagnostics website
- Choose your city and preferred centre location
- Visit the centre at your scheduled time for sample collection (Monday to Saturday)
- Receive your report via email or WhatsApp within 3 days of sample receipt
Frequently Asked Questions
The del7q (Monosomy 7) by FISH test detects chromosomal deletions on chromosome 7 that are associated with myeloid blood disorders, particularly MDS and AML. It helps doctors confirm a diagnosis, assess prognosis, and guide treatment decisions. The test uses fluorescent probes to identify changes that would not be visible under a standard microscope.
Loss of chromosome 7 or deletion of its long arm is one of the most common chromosomal changes seen in myeloid malignancies. It is present in roughly 10 to 15% of adults with MDS or AML and is associated with a poorer outlook. Identifying this abnormality helps doctors tailor treatment and monitor disease more closely.
Two samples are collected: 3 ml of bone marrow aspirate in a sodium heparin tube and 3 ml of peripheral blood in an EDTA tube. Bone marrow is the preferred sample as it provides a more representative view of the abnormal cell population in myeloid conditions.
Fasting is not required for the FISH test procedure itself. If your doctor plans to use sedation during bone marrow aspiration, you may be asked to fast from midnight the previous night. Always confirm with your doctor beforehand.
Results are typically available within 3 days at Lupin Diagnostics. In some cases, depending on sample quality or clinical complexity, this may take longer. Your doctor will inform you if additional time is needed.
Peripheral blood can be used in some cases, but bone marrow aspirate is preferred. Blood alone may not contain enough abnormal cells to give a reliable result, especially in early or low-grade disease. Your doctor will decide the most suitable sample based on your condition.
A positive result means chromosome 7 abnormalities were detected in a proportion of the cells examined. This finding supports a diagnosis of a myeloid disorder but should not be used alone to initiate treatment. Your doctor will review the result alongside other clinical tests, blood counts, and your overall health history before recommending next steps.
del7q (Monosomy 7) by FISH Test: Booking, Price, and Results
