CLL Panel Deletion/Duplication Detection Test: Booking, Price, and Results
About CLL Panel Deletion/Duplication Detection Test
| Field | Value |
|---|---|
| Also Known As | CLL FISH Panel, CLL Panel by FISH, Chronic Lymphocytic Leukaemia Panel, B-cell CLL Panel, CLL Prognostic Panel |
| Sample Type | Peripheral blood (sodium heparin tube) and bone marrow aspirate |
| Fasting Required | No fasting required |
| Report Time | 15 days |
| Recommended For | Adults diagnosed with or suspected of having CLL; most commonly affects those over 50 years; more frequent in males |
| Price | Starting at ₹10,800 |
What Is a CLL Panel Deletion/Duplication Detection Test?
The CLL Panel Deletion/Duplication Detection test is a specialised genetic test that identifies chromosomal abnormalities in patients with chronic lymphocytic leukaemia (CLL), a cancer of the blood and bone marrow. It uses a laboratory method called MLPA (Multiplex Ligation-dependent Probe Amplification) to detect deletions or duplications in specific chromosomal regions. Also known as the CLL FISH Panel or Chronic Lymphocytic Leukaemia Panel, this test helps doctors understand the nature of the disease and guide treatment decisions. Two sample types are required: peripheral blood and bone marrow.
What Does a CLL Panel Deletion/Duplication Detection Test Measure?
The CLL Panel Deletion/Duplication Detection test examines specific chromosomal regions known to be altered in CLL. Each marker provides information about prognosis and likely disease behaviour.
The following chromosomal markers are assessed in this panel:
| Marker | What It Involves | Prognostic Significance |
|---|---|---|
| Deletion 13q (del13q) | Loss of a segment on chromosome 13 | Favourable prognosis when present as the sole abnormality |
| Deletion 17p (del17p/TP53) | Loss of a segment on chromosome 17 involving the TP53 gene | Unfavourable; associated with poor response to chemotherapy |
| Deletion 11q (del11q/ATM) | Loss of a segment on chromosome 11 involving the ATM gene | Unfavourable; linked to extensive lymph node involvement |
| Trisomy 12 (+12) | Gain of an extra copy of chromosome 12 | Intermediate prognosis |
| IGH Gene Rearrangement | Rearrangement of the immunoglobulin heavy chain gene | Helps exclude an alternative diagnosis called mantle cell lymphoma |
| Deletion 6q (del6q) | Loss of a segment on chromosome 6 | Present in roughly 6% of CLL cases; may indicate a need for more demanding treatment |
Why Is a CLL Panel Deletion/Duplication Detection Test Done?
This test is ordered when CLL is diagnosed or suspected, and also when a patient's condition changes or new treatment options are being considered.
Common Symptoms That May Require This Test
Doctors may recommend the CLL Panel Deletion/Duplication Detection test when a patient presents with the following symptoms:
- Swollen lymph nodes, felt as lumps in the neck, armpits, or groin
- Unexplained fatigue and persistent weakness
- Unintentional weight loss over a short period
- Night sweats without an obvious cause
- Frequent infections due to a weakened immune system
- A sense of fullness or discomfort in the abdomen from an enlarged spleen or liver
- Easy bruising or unexplained fever
Conditions This Test Can Help Detect
This panel is used to identify and assess the following conditions:
- Chronic lymphocytic leukaemia (CLL), the most common form of leukaemia in adults
- Distinguishing CLL from mantle cell lymphoma, which can present similarly
- Risk stratification in confirmed CLL cases to support treatment planning and prognosis estimation
CLL Panel Deletion/Duplication Detection Test for Chronic Disease Monitoring
This test is not limited to initial diagnosis. It may be repeated if there is a change in a patient's clinical status or when alternative treatments are being considered. Monitoring chromosomal changes over time helps the treating haematologist or oncologist understand how the disease is evolving and whether the current treatment approach remains appropriate.
How to Prepare and What to Expect
Preparation for this test is straightforward, though it does involve two sample types. Read the steps below before your appointment.
Do You Need to Fast?
No fasting is required before the CLL Panel Deletion/Duplication Detection test. You may eat and drink normally on the day of collection.
Practical Tips Before Your Test
Keep these points in mind ahead of your appointment:
- Bring a detailed clinical history, including your symptoms, previous test results, and any relevant medical records, as this is required for the test.
- Inform your doctor about all medications and supplements you are currently taking, as some may affect results.
- Stay well hydrated before the appointment.
- If bone marrow collection has been planned, follow any specific instructions given by your healthcare provider, including those related to local anaesthesia.
- Ensure you carry a valid doctor's prescription or referral when booking.
Step-by-Step Procedure
Peripheral Blood Collection
- A healthcare professional will clean the skin at the collection site, usually the inner arm, and locate a suitable vein.
- A needle is used to draw approximately 3 mL of blood, which is collected in a sodium heparin (green top) tube.
- The tube is gently inverted several times to prevent clotting and labelled with your details.
Bone Marrow Collection
- Bone marrow aspiration is performed by a trained specialist, typically under local anaesthesia, to collect a small sample from the hip bone or another suitable site.
- A 3 mL sample is collected in a sodium heparin (green top) tube, labelled, and stored at the correct temperature (2 to 8 degrees Celsius).
- Both samples are dispatched to the laboratory promptly for MLPA analysis.
Factors That Can Affect Accuracy
The following factors may influence the reliability of your results:
- Poor sample quality or an insufficient number of viable cells in the sample
- Delayed transport of samples to the laboratory
- Ongoing chemotherapy or prior treatment, which may alter the detectable cell population
- The current stage of CLL at the time of testing
- Technical variables during laboratory analysis
Understanding Your CLL Panel Deletion/Duplication Detection Test Results
Results from this test require careful interpretation by a specialist. The table below shows what a normal result looks like for each marker and what its absence or presence may suggest.
| Parameter | Normal Result | Interpretation if Detected |
|---|---|---|
| del(13q) | Not detected | Favourable prognosis if present as the sole abnormality |
| del(17p)/TP53 | Not detected | Unfavourable; associated with resistance to standard chemotherapy |
| del(11q)/ATM | Not detected | Unfavourable; linked to extensive lymph node enlargement and disease progression |
| Trisomy 12 | Not detected | Intermediate prognosis |
| IGH Rearrangement | Not detected | Presence may suggest an alternative diagnosis such as mantle cell lymphoma |
| del(6q) | Not detected | May indicate a requirement for more intensive treatment |
When no abnormalities are detected across all markers, the result is considered normal, which itself carries an intermediate prognostic classification in CLL.
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Ongoing treatment and the current stage of CLL can both influence what is detectable in the sample. Prior chemotherapy may change the proportion of abnormal cells visible through testing. Serial testing over time may show shifts in the percentage of abnormal cells, and some patients may show changes in specific deletions at the time of disease relapse.
How to Maintain Healthy Levels
While chromosomal abnormalities cannot be altered through lifestyle changes, the following general measures support overall well-being for patients with CLL:
- Attend all scheduled follow-up appointments with your haematologist or oncologist.
- Eat a balanced diet and stay adequately hydrated to support your body's overall function.
- Practise good hygiene and take precautions to avoid infections, as CLL can reduce the immune system's ability to fight illness.
Lupin Diagnostics CLL Panel Deletion/Duplication Detection Test Price and Home Collection
The CLL Panel Deletion/Duplication Detection test cost at Lupin Diagnostics starts at ₹10,800. Home collection is available, subject to your location and scheduling.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 10800 |
| CHENNAI | 10800 |
| HYDERABAD | 10800 |
| KOLKATA | 10800 |
| NAVI MUMBAI | 10800 |
| PUNE | 10800 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
Home Collection
Lupin Diagnostics offers home collection for the CLL Panel Deletion/Duplication Detection test across multiple cities in India. Blood samples are collected at home by trained phlebotomists, while bone marrow collection will require a visit to an appropriate clinical facility. All samples are processed in NABL-accredited laboratories, and reports are delivered digitally for easy access.
How to Book
Booking the CLL Panel Deletion/Duplication Detection test online is straightforward:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
The CLL Panel Deletion/Duplication Detection test identifies specific chromosomal deletions and duplications in patients with chronic lymphocytic leukaemia. It helps doctors confirm the diagnosis, assess the likely course of the disease, and decide on the most appropriate treatment approach. Results are always reviewed alongside other clinical findings.
No, fasting is not required. You can eat and drink normally before your appointment. No special dietary preparation is needed for either the blood or bone marrow sample collection.
The turnaround time for the CLL Panel Deletion/Duplication Detection test at Lupin Diagnostics is 15 days. This is because the test involves complex genetic analysis that requires careful processing and review by specialist technologists.
Both peripheral blood and bone marrow samples are collected because they allow a thorough examination of the leukaemic cell population. Some chromosomal changes may be more clearly visible in one sample type than the other, and using both improves the completeness of the analysis.
A deletion at chromosome 17p, which involves the TP53 gene, is considered an unfavourable finding in CLL. It is associated with resistance to standard chemotherapy and a more challenging disease course. Your haematologist or oncologist will discuss what this means for your specific treatment plan.
Yes, the CLL Panel Deletion/Duplication Detection test procedure may be repeated if your clinical condition changes or if new treatment options are being considered. Monitoring chromosomal abnormalities over time helps track how the disease is progressing and whether treatment is working as expected.
Abnormal results from this test should be discussed with a haematologist (a specialist in blood disorders) or an oncologist specialising in blood cancers. They will interpret the findings in the context of your full clinical history and advise on next steps.
CLL Panel Deletion/Duplication Detection Test: Booking, Price, and Results
