Chronic Infectious Endometritis Detection Panel Test
About Chronic Infectious Endometritis Detection Panel Test
| Field | Value |
|---|---|
| Also Known As | DICE Panel, Detection of Infectious Chronic Endometritis Panel, CE Panel, Chronic Endometritis PCR Panel |
| Sample Type | Endometrial tissue biopsy (collected via pipelle or hysteroscopy-guided biopsy) in normal saline |
| Fasting Required | No |
| Report Time | 2 days |
| Recommended For | Women of reproductive age, particularly those with infertility, recurrent implantation failure, or recurrent pregnancy loss |
| Price | Starting at ₹3,200 |
What is a Chronic Infectious Endometritis Detection Panel Test?
The Chronic Infectious Endometritis Detection Panel test is a molecular diagnostic test that identifies specific bacteria causing long-term inflammation of the uterine lining. It uses Real-Time PCR (polymerase chain reaction) technology to detect bacterial DNA in a small endometrial tissue sample. Doctors typically order this test for women experiencing unexplained infertility, recurrent IVF implantation failure, or repeated miscarriages. It is also known as the DICE Panel or the Chronic Endometritis PCR Panel.
What Does a Chronic Infectious Endometritis Detection Panel Test Measure?
The Chronic Infectious Endometritis Detection Panel uses Real-Time PCR to check for the DNA of 11 pathogenic bacteria known to cause chronic endometritis. The table below lists all pathogens covered.
| Pathogen | Prevalence in CE Cases | Notes |
|---|---|---|
| Enterococcus faecalis | 19% | Intestinal bacterium that can colonise the uterine lining |
| Staphylococcus aureus | 9% | Gram-positive bacterium |
| Non-tuberculous Mycobacterium | 5.2% | Related to tuberculosis-causing organisms |
| Escherichia coli | 6.8% | Intestinal bacterium |
| Mycoplasma genitalium | 6.2% | Sexually transmitted microorganism |
| Mycoplasma hominis | 5% | Urogenital tract bacterium |
| Streptococcus agalactiae | 4.2% | Group B streptococcus |
| Ureaplasma urealyticum | 4% | Urogenital pathogen |
| Chlamydia trachomatis | 2.4% | Sexually transmitted bacterium |
| Mycobacterium tuberculosis | 1.2% | Bacterium causing tuberculosis |
| Neisseria gonorrhoeae | 0.6% | Bacterium causing gonorrhoea |
Why is a Chronic Infectious Endometritis Detection Panel Test Done?
This test helps doctors identify whether a bacterial infection in the uterine lining is contributing to reproductive difficulties. Below are the common reasons a doctor may request it.
Common Symptoms That May Require This Test
Several symptoms may prompt a doctor to recommend this test. These include:
- Pelvic pain, particularly persistent or recurring pain in the lower abdomen
- Abnormal vaginal discharge that is unusual in colour, quantity, or odour
- Painful intercourse (medically called dyspareunia)
- Irregular vaginal bleeding between periods
- Recurrent urinary tract infections
- Mild gastrointestinal discomfort without a clear cause
Conditions This Test Can Help Detect
The DICE Panel can help identify the following conditions:
- Chronic endometritis, which is a persistent bacterial inflammation of the uterine lining
- Recurrent implantation failure in women undergoing IVF treatment
- Recurrent pregnancy loss linked to an underlying uterine infection
- Unexplained infertility where other causes have been ruled out
- Chronic granulomatous endometritis caused by Mycobacterium tuberculosis, which is particularly relevant in the Indian subcontinent
How to Prepare and What to Expect
The Chronic Infectious Endometritis Detection Panel test procedure involves a minor office-based biopsy. Here is everything you need to know before your appointment.
Do You Need to Fast?
No fasting is required for this test. You may eat and drink normally before your appointment.
Practical Tips Before Your Test
The following steps will help ensure a smooth and accurate test. Please note that a clinical history report is required for this test.
- Bring a detailed clinical history file, including your symptoms, previous test results, reproductive history, and any family history, as this is required for the test
- Avoid scheduling the biopsy immediately before or during your menstrual period, as this can affect the results
- Inform your doctor about all current medications, including supplements and any recent antibiotic use, as antibiotics can lower bacterial detection
- A negative urine pregnancy test is typically required before the procedure
- Pain relievers such as ibuprofen (non-steroidal anti-inflammatory drugs) may be taken before the procedure on your doctor's advice to reduce discomfort
Step-by-Step Procedure
The endometrial biopsy is a short outpatient procedure. Here is what to expect:
- You will be asked to undress from the waist down and lie on a reclined examination table with your feet in stirrups, similar to a routine gynaecological examination.
- A speculum is gently inserted into the vagina so the clinician can see the cervix, which is then cleaned with a sterile solution.
- A thin, flexible suction tube called a pipelle is passed carefully through the cervix into the uterus.
- A small amount of endometrial tissue (the uterine lining) is drawn out through the tube using gentle suction. The entire procedure usually takes less than 15 minutes.
- The tissue sample is placed into a sterile container with normal saline and stored under refrigeration for transport to the laboratory.
- The sample is analysed using Real-Time PCR to detect the DNA of the 11 target bacteria. Your report is typically ready within 2 days.
Factors That Can Affect Accuracy
Certain factors may influence the reliability of results. These include:
- The timing of the biopsy within your menstrual cycle
- Recent use of antibiotics, which may reduce bacterial DNA levels in the sample
- Contamination of the tissue sample with vaginal bacteria during collection
- Improper sample handling or a delay in refrigerated transport to the laboratory
- Inadequate sample volume collected during the biopsy
Understanding Your Chronic Infectious Endometritis Detection Panel Test Results
Results from this test are qualitative, meaning they indicate whether specific bacterial DNA is present or absent. Always review your results with your gynaecologist or fertility specialist.
| Result | Interpretation |
|---|---|
| Not Detected | No DNA from the tested pathogenic bacteria was found in the sample |
| Detected | One or more pathogenic bacteria associated with chronic endometritis were identified |
A positive result indicates the presence of bacteria that may be causing endometritis. A negative result means none of the 11 tested organisms were found, though it does not rule out other pathogens not included in the panel.
Disclaimer: "These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice."
Results During Special Conditions
Certain conditions may influence the accuracy of your results. The timing of sample collection within your menstrual cycle can affect the amount of detectable bacteria. Recent antibiotic use may reduce bacterial DNA to levels below detection, potentially producing a false negative result. Contamination with vaginal bacteria during collection is also a recognised limitation of endometrial sampling.
How to Maintain Healthy Levels
These general wellness tips may support uterine health:
- Practise safe sex to reduce the risk of sexually transmitted infections, several of which are detected by this panel
- Seek prompt medical attention for any pelvic inflammatory disease or unusual vaginal discharge
- Maintain good genital hygiene as part of overall reproductive health care
Lupin Diagnostics Chronic Infectious Endometritis Detection Panel Test Price
The Chronic Infectious Endometritis Detection Panel test cost at Lupin Diagnostics starts at ₹3,200. This test requires a visit to a Lupin Diagnostics centre or clinic, as home collection is not available for tissue biopsy samples.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 3200 |
| CHENNAI | 3200 |
| HYDERABAD | 3200 |
| KOLKATA | 3200 |
| NAVI MUMBAI | 3200 |
| PUNE | 3200 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Chronic Infectious Endometritis Detection Panel test online booking is straightforward through the Lupin Diagnostics website:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time for sample collection by the clinical team.
- Receive your report via email or WhatsApp within 2 days of sample collection.
Frequently Asked Questions
Chronic endometritis is a persistent, low-grade inflammation of the uterine lining caused by a bacterial infection. It is found in up to 40% of women with infertility and is linked to recurrent implantation failure and repeated miscarriage. The Chronic Infectious Endometritis Detection Panel test helps identify the specific bacteria responsible, so targeted treatment can be given.
This test is particularly useful for women with a history of recurrent pregnancy loss, repeated IVF failure, or unexplained infertility. It assesses the bacterial environment of the uterus to determine whether infection may be affecting the chances of successful implantation.
RT-PCR identifies up to 63.6% of positive cases, compared to just 23% detected by standard culture methods. PCR can detect very small amounts of bacterial DNA, including from bacteria that are difficult or impossible to grow in a laboratory culture, making it a more sensitive diagnostic approach.
Mild cramping is common and is similar to menstrual cramps. The procedure itself takes less than 15 minutes. Most women can resume normal daily activities the same day, though light spotting or mild cramping may continue for a day or two afterwards.
Yes. Antibiotic therapy is the primary treatment, and after one course, the resolution rate is approximately 78 to 85%. The specific antibiotic is selected based on which bacteria were identified in the test results. Women whose infection resolves after treatment show higher pregnancy and live birth rates.
A clinician performs a short outpatient procedure in which a thin tube is passed through the cervix into the uterus. A small amount of tissue from the uterine lining is removed using gentle suction. The sample is sent to the laboratory in a sterile container for RT-PCR analysis.
Yes. A detailed clinical history, including your symptoms, reproductive history, previous test results, and family history, is required. You should also inform the clinical team about any medications or recent antibiotic use before the procedure begins.
Chronic Infectious Endometritis Detection Panel Test
