Chromo AI - Peripheral Blood (AI Karyotyping) Test: Booking, Price, and Results
About Chromo AI - Peripheral Blood (AI Karyotyping) Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | AI-assisted karyotyping, AI karyotype, chromosome analysis (AI), digital karyotyping, cytogenetic analysis |
| Sample Type | Peripheral blood (sodium heparin tube) |
| Fasting Required | No |
| Report Time | 6 days |
| Recommended For | All genders and age groups |
| Price | Starting at ₹8,000 |
What is a Chromo AI - Peripheral Blood (AI Karyotyping) Test?
The Chromo AI - peripheral blood (AI karyotyping) test is a specialised chromosomal analysis that examines the number, size, shape, and structure of chromosomes in a blood sample. It uses G-banding, a laboratory technique that stains chromosomes to reveal distinct patterns, combined with artificial intelligence software to produce accurate, detailed chromosome images for review by a specialist. The test is also known as AI-assisted karyotyping, AI karyotype, chromosome analysis (AI), digital karyotyping, or cytogenetic analysis. A small blood sample drawn from a vein in the arm is all that is needed.
What Does a Chromo AI - Peripheral Blood (AI Karyotyping) Test Measure?
This test examines your chromosomes at a high-resolution level. The table below outlines the key parameters assessed:
| Parameter | What It Checks |
|---|---|
| Chromosome count | Confirms the presence of 46 chromosomes in 23 pairs |
| Chromosome structure | Detects breaks, deletions, duplications, inversions, or rearrangements |
| Sex chromosome complement | Identifies the XX (female) or XY (male) configuration |
| Banding patterns | G-banding patterns help identify each individual chromosome |
AI algorithms within the karyotyping software automate chromosome identification and arrangement, allowing laboratory specialists to review accurate images more efficiently.
Why is a Chromo AI - Peripheral Blood (AI Karyotyping) Test Done?
A doctor may order this test for several clinical reasons, from investigating unexplained symptoms to evaluating blood disorders.
Common Symptoms That May Require This Test
The following symptoms are among the most common reasons a doctor may request this test:
- Developmental delays or intellectual disability in a child
- Infertility in men or women, including very low or absent sperm counts
- Recurrent miscarriages (two or more pregnancy losses)
- Unusual physical features present from birth
- Delayed puberty or absent secondary sexual development
- Abnormal results on other genetic or blood screening tests
- Suspected blood cancer or related haematological condition
Conditions This Test Can Help Detect
This test can help identify a range of chromosomal conditions. These include:
- Down syndrome (trisomy 21), caused by an extra copy of chromosome 21
- Turner syndrome, caused by the partial or complete absence of one X chromosome
- Klinefelter syndrome (47, XXY), in which males carry an extra X chromosome
- Edwards syndrome (trisomy 18), associated with severe organ problems
- Patau syndrome (trisomy 13), linked to poor development
- Philadelphia chromosome, found in the majority of cases of chronic myelogenous leukaemia (CML)
- Balanced translocations associated with infertility or repeated pregnancy loss
How to Prepare and What to Expect
The Chromo AI - peripheral blood (AI karyotyping) test procedure is straightforward. No special preparation is needed beforehand, but a few practical steps will help ensure your sample is suitable for analysis.
Do You Need to Fast?
No, fasting is not required for this test. You can eat and drink normally before your appointment. If you are having additional tests at the same time, your doctor will advise you separately on any fasting requirements for those.
Practical Tips Before Your Test
A few simple steps will help ensure the sample is collected smoothly and the results are as accurate as possible:
- Bring a duly filled test request form (TRF), a detailed clinical history, and a completed consent form, as these are required for this test
- Inform your doctor if you have had a recent whole blood transfusion; a waiting period of 10 days post-transfusion is recommended before sample collection for cytogenetic testing
- Tell your doctor about any chemotherapy you are currently receiving or have recently completed, as this can affect results
- Inform your doctor or phlebotomist about any medications you are currently taking
- Wear a loose-sleeved top for easy access to your arm
- Stay well hydrated before your appointment to make the blood draw easier
Step-by-Step Procedure
- A trained phlebotomist cleans the skin over a vein in your arm with a sterile antiseptic.
- A small amount of blood (approximately 3 ml) is drawn from the vein using a fine needle.
- The blood is collected into a green-top sodium heparin tube, which prevents the sample from clotting.
- The tube is gently inverted several times to ensure the anticoagulant mixes evenly with the blood.
- The sample is labelled with your details and stored at the correct temperature (2 to 8°C) for refrigerated transport to the laboratory.
- In the laboratory, white blood cells are cultured and arrested at the stage of cell division that allows chromosomes to be clearly visualised. G-Banding staining and AI-assisted analysis are then performed.
- A qualified cytogenetics specialist then reviews the findings and prepares your final report.
Factors That Can Affect Accuracy
Certain situations may influence the quality of results. These include:
- Recent whole blood transfusion (waiting 10 days is recommended)
- Current or recent chemotherapy, which can cause chromosome breaks
- Poor sample quality or low cell viability at the time of collection
- Culture failure in the laboratory, which may require repeat testing
- Delays in sample transport or improper storage temperature
Understanding Your Chromo AI - Peripheral Blood (AI Karyotyping) Test Results
Your results describe the chromosomal makeup observed in your blood cells. A trained specialist will interpret them alongside your clinical history. The standard reference ranges are shown in the table below:
| Parameter | Normal Range |
|---|---|
| Chromosome complement (female) | 46, XX |
| Chromosome complement (male) | 46, XY |
| Total chromosome count | 46 (in 23 pairs) |
| Autosomes | 22 pairs |
| Sex chromosomes | 1 pair (XX or XY) |
A normal result means no extra, missing, or structurally altered chromosomes were found. An abnormal result may show aneuploidy (an incorrect number of chromosomes), structural rearrangements such as translocations or inversions, or patterns associated with specific conditions such as Down syndrome, Turner syndrome, or leukaemia-related chromosomal changes.
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain circumstances can influence how results should be read:
- Chemotherapy can cause breaks in chromosomes that appear in the karyotype images. Your doctor should be informed if you are undergoing or have recently completed chemotherapy before the results are interpreted.
- If you received a whole blood transfusion shortly before the test, the chromosomes of the donor's blood cells may be present in the sample. Waiting 10 days after a whole blood transfusion is recommended to avoid this. No waiting period is needed after receiving only red cells or plasma.
- In rare cases, cells may not grow adequately in the laboratory culture. If this happens, a repeat blood sample may be required.
How to Maintain Healthy Levels
Chromosomal makeup is established at conception and cannot be altered through diet or lifestyle. The following steps can still be helpful:
- If your results are abnormal, seek genetic counselling to understand what the findings mean for you and your family
- Couples with reproductive concerns, such as repeated miscarriage or infertility, may benefit from both partners being tested
- Maintain regular follow-up appointments with your doctor or genetic specialist for ongoing guidance
Lupin Diagnostics Chromo AI - Peripheral Blood (AI Karyotyping) Test Price and Home Collection
The Chromo AI - peripheral blood (AI karyotyping) test cost starts at ₹8,000 at Lupin Diagnostics, and home sample collection is available across cities in India. The table below shows indicative prices:
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 5800 |
| CHENNAI | 5800 |
| HYDERABAD | 5800 |
| KOLKATA | 5800 |
| NAVI MUMBAI | 5800 |
| PUNE | 5800 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within 6 days.
Home Collection
Lupin Diagnostics offers Chromo AI - peripheral blood (AI karyotyping) test home collection across multiple cities in India. Your blood sample is collected by a trained phlebotomist at a time that suits you and transported to an NABL-accredited laboratory for processing. Your digital report is made available via email or WhatsApp once ready.
Frequently Asked Questions
Traditional karyotyping requires a laboratory specialist to manually identify, sort, and analyse each chromosome image, which is time-consuming. The Chromo AI - peripheral blood (AI karyotyping) test uses AI software to automate chromosome identification and arrangement, reducing turnaround time and improving image quality. A trained specialist still reviews and confirms every result before the report is issued.
The report is delivered within 6 days at Lupin Diagnostics. The test results are delivered directly via email or WhatsApp once they are ready.
The test involves a standard blood draw from a vein in your arm. You may feel a mild sting when the needle is inserted, but the process usually takes less than five minutes and causes no lasting discomfort.
No. Karyotyping identifies large chromosomal abnormalities, such as missing or extra chromosomes and major structural changes. It cannot detect small-scale changes like point mutations or tiny insertions and deletions. For smaller genetic changes, your doctor may recommend chromosomal microarray or next-generation sequencing.
This test is recommended for individuals with unexplained developmental delays, unusual physical features, or a family history of chromosomal conditions. Couples experiencing infertility or repeated miscarriages, and individuals with suspected blood cancers or haematological disorders, may also be advised to get this test.
A normal result (46, XX or 46, XY with no structural abnormalities) means no large chromosomal changes were detected. However, it does not rule out all genetic conditions. Some disorders are caused by changes too small for karyotyping to identify. Always discuss your results with your doctor for complete guidance.
Chromo AI - Peripheral Blood (AI Karyotyping) Test: Booking, Price, and Results
