Chromo AI High Resolution- Peripheral Blood Test
About Chromo AI High Resolution- Peripheral Blood Test
| Field | Value |
|---|---|
| Also Known As | High-resolution karyotyping, Blood Karyotype, G-banded Chromosome Analysis, Cytogenetic Analysis, AI-assisted Karyotyping |
| Sample Type | Peripheral blood (sodium heparin tube) |
| Fasting Required | No fasting required |
| Report Time | 6 days |
| Recommended For | All ages and genders; particularly individuals with suspected genetic disorders, couples with infertility or recurrent pregnancy loss, and children with developmental delays |
| Price | Starting at ₹8,000 |
What is a Chromo AI High Resolution- Peripheral Blood Test?
The Chromo AI high resolution- peripheral blood test is a specialised cytogenetic (cell genetics) test that examines the number and structure of chromosomes in your blood cells. The test uses a technique called G-banding, combined with AI-assisted analysis, to produce a detailed picture of your chromosomes called a karyotype. It is typically ordered by a doctor or genetic specialist when a chromosomal abnormality is suspected. The test is also known as high-resolution karyotyping, blood karyotype, G-banded chromosome analysis, cytogenetic analysis, or AI-assisted karyotyping. A small blood sample is collected from a vein and sent to the laboratory for analysis.
What Does a Chromo AI High Resolution- Peripheral Blood Test Measure?
This test analyses the chromosomes present in your blood cells, looking at their number, size, and shape in fine detail. The table below summarises what the test examines:
| Component | What It Looks At |
|---|---|
| Chromosome number | Checks whether all 46 chromosomes are present (23 pairs) |
| Chromosome structure | Identifies deletions, duplications, translocations, or inversions |
| Banding patterns | Uses G-banding (Giemsa stain) to create light and dark bands for identifying each chromosome |
| AI-enhanced analysis | Automated software assists with chromosome classification, improving accuracy and speed |
High-resolution analysis examines chromosomes at 550 bands or above, allowing detection of smaller abnormalities that standard karyotyping may miss.
Why is a Chromo AI High Resolution- Peripheral Blood Test Done?
Doctors order this test when they suspect a chromosomal abnormality may be causing certain symptoms or health concerns.
Common Symptoms That May Require This Test
The following symptoms are among the most common reasons a doctor may recommend the Chromo AI high resolution- peripheral blood test:
- Developmental delay or intellectual disability in a child
- Multiple birth defects or unusual physical features
- Unexplained infertility in men or women
- Recurrent miscarriages (two or more pregnancy losses)
- Absence of menstruation (primary amenorrhoea) in females
- Ambiguous genitalia at birth
- Abnormal results on a prenatal ultrasound or biochemical screening
Conditions This Test Can Help Detect
This test can help identify a range of chromosomal conditions, including:
- Down syndrome (trisomy 21), which causes developmental delays and intellectual disabilities
- Edwards syndrome (trisomy 18), which affects the lungs, kidneys, and heart
- Patau syndrome (trisomy 13), associated with poor foetal development and low birth weight
- Turner syndrome (45,X), the most common genetic cause of primary amenorrhoea in females
- Klinefelter syndrome (47,XXY), which affects males and is often linked to infertility
- Balanced translocations, which are chromosome rearrangements that can cause fertility problems
- Certain blood disorders and haematological conditions such as anaemia, leukaemia, or lymphoma
How to Prepare and What to Expect
No special preparation is needed for this test, but a few simple steps will help ensure a smooth experience.
Do You Need to Fast?
No, fasting is not required. You can eat and drink normally before the Chromo AI high resolution- peripheral blood test. If other tests have been ordered at the same time, check with your doctor whether those require fasting. Always follow specific instructions provided by your doctor.
Practical Tips Before Your Test
The following tips will help ensure a smooth sample collection:
- Bring a duly filled Test Request Form (TRF), your detailed clinical history, and a signed consent form, as these are required for this test
- Inform the phlebotomist if you have had a recent blood transfusion or bone marrow transplant
- Let your doctor know about any medications, blood thinners, or supplements you are currently taking
- Drink adequate water before your appointment to make the blood draw easier
- Wear a loose-sleeved top for easy access to your arm
Step-by-Step Procedure
Here is what happens during the Chromo AI high resolution- peripheral blood test procedure:
- A trained phlebotomist cleans a small area of your arm with an antiseptic wipe and draws approximately 3 ml of blood from a vein using a sterile needle.
- The blood is collected into a green-top sodium heparin tube. The tube is gently inverted several times to prevent the blood from clotting.
- The sample is stored at refrigerated temperature (2°C to 8°C) and dispatched to the laboratory promptly. The sample must never be frozen.
- In the laboratory, the blood cells are cultured for approximately 72 hours in a controlled environment to encourage cell division.
- Once enough cells are dividing, they are treated with a staining technique (G-banding) to make the chromosome bands visible under a microscope.
- AI-assisted software helps classify and arrange the chromosomes into a karyotype image, which is then reviewed and reported by a certified cytogeneticist.
Factors That Can Affect Accuracy
Certain factors can affect the quality of the test result:
- Poor sample handling, such as freezing the sample or significant delay in transport
- A clotted blood sample, which cannot be used for cell culture
- A recent blood transfusion or bone marrow transplant, which may introduce donor cells
- Low cell viability if the sample is not handled correctly
- Low-level chromosomal mosaicism (where only some cells carry an abnormality) may occasionally be missed
Understanding Your Chromo AI High Resolution- Peripheral Blood Test Results
Results should always be reviewed with a qualified doctor or genetic counsellor. The table below shows the standard reference ranges for this test:
| Parameter | Normal Result | Interpretation |
|---|---|---|
| Females | 46, XX | 46 total chromosomes; two X sex chromosomes |
| Males | 46, XY | 46 total chromosomes; one X and one Y sex chromosome |
A normal (negative) result means no visible chromosomal abnormality was found. An abnormal (positive) result indicates a change in chromosome number or structure, which your doctor will explain in detail.
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain situations can influence how results are interpreted:
- If chromosomal mosaicism is present (where some cells carry a different chromosome pattern), it may occasionally be missed due to the limited number of cells analysed.
- A recent bone marrow transplant may introduce donor cells into the blood, which can affect the chromosome picture.
- A normal result does not rule out very small genetic changes (submicroscopic abnormalities) or changes caused by single-gene mutations. Additional tests such as chromosomal microarray may be needed.
How to Maintain Healthy Levels
Chromosome abnormalities detected by this test are generally present from birth and are not caused or corrected by lifestyle choices. The following guidance is relevant after receiving results:
- Seek genetic counselling before and after testing to understand what the findings mean for you and your family.
- If an abnormality is identified, consult a medical genetics specialist for further evaluation and guidance.
- Share your results with all treating doctors, as the findings can influence management across multiple specialities.
Lupin Diagnostics Chromo AI High Resolution- Peripheral Blood Test Price and Home Collection
The Chromo AI high resolution- peripheral blood test cost starts at ₹8,000 at Lupin Diagnostics, with home collection available across cities in India. The table below shows indicative prices:
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 8000 |
| CHENNAI | 8000 |
| HYDERABAD | 8000 |
| KOLKATA | 8000 |
| NAVI MUMBAI | 8000 |
| PUNE | 8000 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Follow these steps for Chromo AI high resolution- peripheral blood test online booking:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Home Collection
Lupin Diagnostics offers Chromo AI high resolution- peripheral blood test home collection across cities in India. A certified phlebotomist visits your home at the scheduled time, collects the blood sample in the correct container, and dispatches it to the laboratory under the required storage conditions. All samples are processed in NABL-accredited laboratories, and your digital report is made available within the turnaround period.
Frequently Asked Questions
Standard karyotyping analyses chromosomes at lower band resolution, which can identify large numerical and structural changes. High-resolution karyotyping examines chromosomes at 550 bands or above, allowing detection of smaller, subtler abnormalities that standard methods may miss. The Chromo AI high resolution- peripheral blood test uses this detailed approach combined with AI-assisted classification for greater accuracy.
The report is typically delivered within 6 days at Lupin Diagnostics. The test results are delivered via email or WhatsApp once they are ready.
The blood draw is generally well tolerated. You may feel a brief sting when the needle is inserted, and there may be mild bruising at the collection site afterwards. These effects are temporary and resolve quickly.
Manual chromosome analysis is a time-consuming and labour-intensive process. AI-assisted karyotyping software helps automatically segment and classify chromosomes, reducing the time needed for analysis and minimising the chance of human error. Studies show that AI-based systems can correctly classify the large majority of chromosomes, supporting faster and more consistent results.
This test is recommended for children with unexplained developmental delay or intellectual disability, couples experiencing recurrent miscarriages or infertility, men with a very low sperm count, individuals with multiple birth defects, and women with absent or delayed menstruation. Your doctor will advise whether this test is appropriate based on your specific situation.
No. A normal karyotype means no chromosome abnormality was detected at the resolution of this test. However, very small genetic changes (submicroscopic abnormalities), single-gene mutations, and low-level mosaicism may not be visible. If clinical concern remains after a normal result, your doctor may recommend additional tests such as chromosomal microarray or gene sequencing.
You will need to bring a duly filled Test Request Form (TRF); a detailed clinical history, including your symptoms and relevant medical records; and a signed consent form. These documents are required for the test to be processed. If you are booking a home collection, please ensure these are ready before the phlebotomist arrives.
Chromo AI High Resolution- Peripheral Blood Test
