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Chromo AI – Amniotic Fluid/CV/POC Test: Booking, Price, and Results

About Chromo AI – Amniotic Fluid/CV/POC Test: Booking, Price, and Results

Field	Value
Also Known As	Prenatal Chromosomal Analysis, Chromosomal Microarray Analysis (CMA), Prenatal Genetic Analysis
Sample Type	Chorionic villi (CVS), amniotic fluid, or products of conception (POC) tissue
Fasting Required	No fasting required
Report Time	10 days
Recommended For	Pregnant women with high-risk indications; couples with recurrent pregnancy loss
Price	Starting at ₹5,800

What is a Chromo AI – Amniotic Fluid/CV/POC Test?

The Chromo AI – amniotic fluid/CV/POC test is a prenatal chromosomal analysis that examines genetic material from foetal cells. It is performed using samples collected from chorionic villi (CVS), amniotic fluid, or products of conception tissue. Doctors recommend this test when there is a clinical reason to investigate the chromosomal make-up of the foetus or to understand the cause of a pregnancy loss. It is also known as prenatal chromosomal analysis, chromosomal microarray analysis (CMA), or prenatal genetic analysis.

What Does a Chromo AI – Amniotic Fluid/CV/POC Test Measure?

This test analyses chromosomes in foetal cells to look for genetic changes. The method used is G-banding, which produces a visual map of the chromosomes. The table below explains what the test looks for:

Component	What It Checks
Aneuploidy	Abnormal number of chromosomes (e.g., an extra or missing chromosome)
Microdeletions	Small missing segments of chromosomal material
Microduplications	Small extra segments of chromosomal material
Copy Number Variations (CNVs)	Gains or losses of genetic material across the genome
Trisomies (13, 18, 21)	Extra copy of chromosome 13, 18, or 21
Sex chromosome abnormalities	Atypical number or structure of X or Y chromosomes
Maternal Cell Contamination (MCC)	Detection of maternal DNA in the foetal sample using STR analysis

Why is a Chromo AI – Amniotic Fluid/CV/POC Test Done?

This test is requested when a doctor needs a definitive chromosomal diagnosis during pregnancy or following pregnancy loss.

Common Symptoms That May Require This Test

Several clinical findings may lead a doctor to recommend the Chromo AI – amniotic fluid/CV/POC test:

Abnormal results from maternal screening tests (e.g., high-risk NIPT or serum screening)
Structural abnormality detected on a foetal ultrasound scan
Increased nuchal translucency (excess fluid at the back of the foetal neck) on scan
Advanced maternal age, which is associated with higher chromosomal risk
Previous pregnancy affected by a chromosomal condition
Family history of a known chromosome abnormality
Recurrent pregnancy loss or unexplained miscarriages

Conditions This Test Can Help Detect

The test can identify a range of chromosomal conditions, including:

Trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), and trisomy 13 (Patau syndrome)
Sex chromosome abnormalities
DiGeorge syndrome, Williams-Beuren syndrome, Prader-Willi syndrome, Angelman syndrome, and 1p36 deletion syndrome
Chromosomal abnormalities associated with recurrent spontaneous abortions (estimated to account for 15% to 60% of cases)
Trisomy 16 and monosomy X (Turner syndrome), which are among the most common findings in first-trimester miscarriages

Chromo AI – Amniotic Fluid/CV/POC Test During Pregnancy

This test is a standard invasive prenatal diagnostic option for pregnant women with high-risk indications. Amniocentesis is generally carried out between weeks 15 and 20 of pregnancy, while CVS is typically performed between weeks 10 and 13. Prenatal diagnosis through these methods can identify chromosomal abnormalities, certain gene disorders, and X-linked conditions before birth.

How to Prepare and What to Expect

Preparation varies depending on the type of sample being collected. Your doctor will provide specific guidance before your appointment.

Do You Need to Fast?

No fasting is required for this test. You can eat and drink as normal before your appointment. Always follow specific instructions provided by your doctor.

Practical Tips Before Your Test

The following points will help you prepare for your appointment:

Bring a complete clinical history including your symptoms, previous test results, and family history, as this is required for the test. Also bring a duly filled Test Request Form (TRF), Form G, and the PCPCNDT Form.
Tell your doctor about all medicines, supplements, vitamins, and herbal products you are taking.
Inform your doctor if you are allergic to latex or anaesthesia.
If your blood type is rhesus negative (e.g., A-, B-, O-, or AB-), ask your doctor whether an anti-D injection is needed.
In some cases, you may be advised to avoid emptying your bladder for a few hours before the procedure, as a full bladder can make the procedure easier.

Step-by-Step Procedure

The Chromo AI – amniotic fluid/CV/POC test procedure differs depending on which sample type is being taken. Here is what you can expect during the sample collection:

Amniotic Fluid (Amniocentesis):

You lie down and the doctor performs an ultrasound scan to locate the baby. Your abdomen is cleaned with antiseptic.
A thin needle is carefully inserted through the abdomen into the womb under continuous ultrasound guidance. This may feel uncomfortable but is not usually painful.
A small amount of amniotic fluid is withdrawn through the needle.
The whole procedure takes around 10 minutes. You are monitored for up to one hour afterwards.
You can usually go home after monitoring. Arrange for someone to drive you.

Chorionic Villi (CVS):

An ultrasound scan is performed to check foetal position. The abdomen is cleaned with antiseptic.
A local anaesthetic may be given to numb the skin. A fine needle is passed through the abdominal wall into the chorionic tissue under ultrasound guidance.
A tiny piece of chorionic tissue (roughly the size of a few grains of rice) is removed and sent to the laboratory in a sterile container.

Products of Conception (POC):

POC tissue is collected in as sterile a manner as possible immediately after pregnancy loss.
The specimen is placed in normal saline with two drops of gentamycin and sent to the laboratory in a sterile container at refrigerated temperature (2 to 8°C).

Factors That Can Affect Accuracy

The following factors may influence the quality or reliability of test results:

Poor sample quality or degraded DNA from the specimen
High levels of maternal cell contamination (above 15%) in amniotic fluid or CVS samples
Low-level mosaicism (a small fraction of cells carrying an abnormality) may not always be detected
Very small chromosomal changes below the test's resolution limit will not be identified
Balanced translocations and certain complex chromosome patterns are better assessed by standard karyotyping

Understanding Your Chromo AI – Amniotic Fluid/CV/POC Test Results

Results from this test are qualitative rather than numerical. Your doctor or genetic counsellor will review the findings alongside your full clinical picture. The table below summarises the key findings:

Finding Category	Interpretation
Normal / Negative	No significant chromosomal abnormalities detected
Abnormal / Positive	A chromosomal abnormality has been identified (e.g., a trisomy, deletion, or duplication)
Variant of Uncertain Significance (VUS)	A genetic change has been found whose clinical meaning is not yet fully understood

Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.

Results During Special Conditions

Maternal cell contamination is possible when studying amniotic fluid or CVS samples. Samples with more than 15% maternal DNA contamination are not suitable for further genetic analysis. Additionally, this test cannot reliably identify balanced translocations, pericentric inversions, or certain chromosome polymorphisms; standard karyotyping may be more appropriate for those specific findings.

How to Maintain Healthy Levels

Because this is a diagnostic test rather than a monitoring test, the focus after receiving results is on informed follow-up care:

Seek genetic counselling both before and after testing to understand what the results mean for your family.
Continue regular prenatal care and follow-up ultrasound scans as advised by your doctor.
If an abnormality is detected, a maternal-foetal medicine specialist or genetic counsellor can help you understand your options.

Lupin Diagnostics Chromo AI – Amniotic Fluid/CV/POC Test Price

The Chromo AI – amniotic fluid/CV/POC test cost at Lupin Diagnostics starts at ₹5,800. This test requires a visit to a Lupin Diagnostics centre or collection point; home collection is not available because the sample must be collected by a trained specialist in a clinical setting. The table below shows indicative prices:

City	Approximate Price (₹)
BHOPAL	5800
CHENNAI	5800
HYDERABAD	5800
KOLKATA	5800
NAVI MUMBAI	5800
PUNE	5800

Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.

How to Book

Follow these steps for Chromo AI – amniotic fluid/CV/POC test online booking:

Select the test on the Lupin Diagnostics website.
Choose your city and preferred centre location.
Visit the centre at your scheduled time for sample collection by the specialist team.
Receive your report via email or WhatsApp within the stipulated turnaround time.

Frequently Asked Questions

This is an invasive prenatal diagnostic test that examines chromosomes in foetal cells from amniotic fluid, chorionic villi, or products of conception tissue. It is used to confirm or rule out chromosomal abnormalities in the foetus. The Chromo AI – amniotic fluid/CV/POC test procedure is recommended when there is a clinical or genetic reason to look more closely at foetal chromosomes.

For amniocentesis, the test is usually done between 15 and 20 weeks of pregnancy. CVS is typically recommended between weeks 10 and 13. POC testing is carried out after a pregnancy loss, recurrent miscarriages, or when an abnormal ultrasound finding was noted before the loss.

No. The Chromo AI – amniotic fluid/CV/POC test home collection option is not available. Amniocentesis and CVS are invasive procedures that must be performed by a trained specialist in a clinical environment. The sample cannot be collected from a maternal blood draw alone.

This test uses G-banding and chromosomal microarray techniques that can identify microdeletions and microduplications too small for standard karyotyping to detect. Studies suggest chromosomal microarray analysis reveals an additional diagnosis in approximately 6% to 10% of cases compared to karyotyping in foetuses with structural abnormalities.

At Lupin Diagnostics, the report time for Chromo AI – amniotic fluid/CV/POC test is 10 days. The test results are delivered directly via email or WhatsApp.

NIPT (non-invasive prenatal testing) is a screening test that carries no procedural risk but can only indicate the possibility of a problem, not confirm it. The Chromo AI – amniotic fluid/CV/POC test is a diagnostic test that gives a near-definitive answer about whether a specific chromosomal condition is present. If NIPT shows a high-risk result, this test may be recommended to confirm the finding.