CCND1/BCL1 Test: Booking, Price, and Results

This test analyses a single genetic event using a method called FISH (fluorescence in situ hybridisation). Fluorescent probes attach to specific parts of the chromosomes, allowing laboratory specialists to detect abnormal signal patterns under a microscope.

The table below explains what is measured:

The CCND1 gene (also called BCL1 or cyclin D1) normally helps regulate cell growth. When it translocates to the IGH region, it can cause uncontrolled cell division, which is a key feature of mantle cell lymphoma.

Preparing for the CCND1/BCL1 test procedure is straightforward, though the sample collection method depends on what your doctor has recommended.

Do You Need to Fast?

No fasting is required before this test. You may eat and drink normally on the day of sample collection. Always follow specific instructions for the biopsy procedure provided by your doctor.

Practical Tips Before Your Test

Keep these points in mind before attending your appointment:

• Bring a detailed clinical history including your symptoms, previous test results, and any relevant medical records, as this is required for the test
• Inform your doctor about all medications you take, particularly blood thinners
• Disclose any past history of blood disorders or cancer treatment
• Wear comfortable, loose clothing that allows easy access to the collection site
• If a bone marrow biopsy is planned, arrange for someone to accompany you to the centre

Step-by-Step Procedure

This test uses two possible sample types: bone marrow aspirate and peripheral blood. The procedure for both samples is provided below:

Bone Marrow Aspirate Collection:

The following steps describe bone marrow sample collection:

1. You will be asked to lie on your side or stomach. Most samples are taken from the iliac crest, a bone at the back of the hip.
2. The skin and bone surface are cleaned and numbed with a local anaesthetic injection.
3. A thin needle is inserted through the bone to draw a small amount of liquid bone marrow.
4. The sample is placed in the appropriate collection tube and labelled for transport.
5. The sample is stored at ambient temperature (2 to 8°C) and dispatched to the laboratory.
6. In the laboratory, FISH analysis is performed, and your report is delivered within 8 days.

Peripheral Blood Collection:

Here are the steps involved in blood sample collection:

1. A healthcare professional cleans the skin over a vein, usually in the arm.
2. A needle is inserted, and a small blood sample (3 ml) is drawn into the appropriate collection tube.
3. The sample is stored whole in the original tube at ambient temperature (2 to 8°C) and dispatched to the laboratory promptly.

Factors That Can Affect Accuracy

The following factors may influence how reliable your results are:

• Quality of the sample collected
• Delayed delivery to the laboratory
• Improper storage, such as freezing the specimen
• Insufficient number of cells in the sample

This test detects a chromosomal change that is not influenced by lifestyle factors. However, these general steps support your overall wellbeing:

• Keep all follow-up appointments with your haematologist or oncologist as advised
• Maintain a balanced diet and stay well hydrated during the testing and treatment period
• Speak openly with your care team about any new or worsening symptoms

Follow these steps for CCND1/BCL1 test online booking:

1. Select the test on the Lupin Diagnostics website.
2. Choose your city and preferred centre location.
3. Visit the centre at your scheduled time for peripheral blood sample collection. For bone marrow samples, visit a hospital as directed by your doctor.
4. Receive your report via email or WhatsApp within the stipulated turnaround time.