CA 125 test
CA 125 test
CA 125 (cancer antigen 125) is a protein, a type of biomarker, or a substance found in your blood that may indicate the presence of an underlying disease or condition. In general, a high CA 125 may be a sign of cancer. If you have cancer, measuring tumour markers may provide useful information in determining how to treat your disease.
CA 125 test is a blood test that measures the levels of CA 125 antigen in your blood samples. High levels of CA 125 are often associated with ovarian cancers.
Other names for CA 125 test: cancer antigen 125, CA-125 tumour marker, glycoprotein antigen, and ovarian cancer antigen
Symptoms of ovarian cancer:
Some common symptoms of ovarian cancer include:
Bloating
Pelvic or abdominal pain
Difficulty eating or feeling full quickly
Urinary symptoms (frequency or urgency)
What is CA 125 test used for?
1
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To see how well the cancer treatment is working and to check if ovarian cancer has relapsed
2
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To understand more about the lump in the pelvis (region below the belly)
3
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To screen for ovarian cancer if you are at risk
Who should get tested?
A CA 125 test is indicated in individuals who:
Have had Ovarian cancer
Have lump in the pelvis region that could be tumour
Have a family history of ovarian cancer
Are a carrier of BRCA gene (indicates an increased risk of developing cancer)
Test preparation
A healthcare provider will draw the blood sample from a vein in your arm, using a small needle. It usually takes a few minutes to draw the blood sample
Interpretation of results
Normal range: 0-35 U/mL
Deviations from the normal ranges:
Results are always reviewed based on the normal values of CA 125 in the blood.
·      If you already have ovarian cancer and you are on treatment, and the test results show decreased values than previous, it means that the treatment is working for you. If not, then it is an indication that the treatment is not working for you.
·      If you have finished your ovarian cancer treatment, and now you see an increase in the levels of CA 125, it indicates that your cancer is coming back.
·      If you see a lump in your pelvis region, and the test results show high CA 125 levels, then it must be a sign of a growing tumour in your ovaries. You will be advised for more tests to confirm the diagnosis.
However, a high CA 125 level doesn’t usually give an indication of cancer. It is also increased in the following conditions- endometriosis, pelvic inflammatory disease, liver diseases, pregnancy, and uterine fibroids
FAQs
What is the turnaround time (TAT) for CA 125 test?
The results for CA 125 test will usually be given 5-7 days after the sample collection. However, it might take a little longer at times
Are there any risks associated with CA 125 test?
CA 125 test is a simple blood test that involves negligible risks. A little sting or bruise might be noticed when the needle is inserted to draw your blood sample. It often subsides within few minutes to a couple of hours
Can it be possible that I have false-negative results?
Yes, it is possible to get false-negative results. If you are in the early stages of cancer, your CA 125 levels may be low. If you are experiencing symptoms of ovarian cancer, it is always advised to repeat the test after a few days
I have ovarian cancer but my CA 125 levels are normal. What does it mean?
It is normal to have normal CA 125 levels even if you have ovarian cancer. It is falsely reassuring that you have no cancer if your CA 125 levels are normal. However, if you notice any signs of cancer, it is always a good idea to run additional tests to rule out the presence of the disease
I am being treated for ovarian cancer but my CA 125 levels are not reduced. Does this mean my treatment is not working?
 CA 125 test is recommended to determine whether or not the given treatment is effective. If the levels do not change significantly after treatment, it means that your treatment did not work and you need to change your treatment strategy. Your healthcare provider will assist you in fully comprehending the results and, if necessary, changing your treatment
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