C5 Complement
Blood Sample
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About C5 Complement
C5 Complement test is done to measure the amount of C5 proteins in the blood. The C5 complement component is a plasma glycoprotein which is synthesized in the monocytes, lymphocytes, and liver.
The Complement System helps the immune system to produce antibodies and make them more effective. The system eliminates dead cells and other wastes from the body, and recognizes and neutralizes bacteria and viruses.
C5 complement test helps your healthcare provider diagnose, increased incidence of autoimmune disorders such as lupus, susceptibility to bacterial infections, and complement-mediated renal diseases.
C5 Complement test is also known as C5, complement antigen, complement activity C5, complement component 5.
Symptoms Of Lupus
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Skin rash (a butterfly rash) across your cheeks
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Fever
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Swollen lymph nodes
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Hearing loss
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Vision loss
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Hair loss
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Weight loss
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Mouth ulcers
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Headache
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Extreme tiredness
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Pain in the chest
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Joint pain and swelling
What Is a C5 Complement Test Used For?
C5 Complement test is recommended in the following conditions
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Recurrent bacterial infections
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Diagnose autoimmune disorders e.g. lupus
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Complement-mediated renal diseases such as glomerulonephritis (GN) and vasculitis
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Determine treatment plan for an autoimmune disease
Test preparation:
A fasting sample is preferred but not necessarily required for C5 Complement test. It is advised to consult your healthcare provider before undergoing the test.
Normal range of C5 proteins varies between 10.6-26.3 milligrams per deciliter (mg/dl), depending on age, gender, and overall health of the individual.
Deviations from normal levels indicates the following:
A. Lower than normal levels could mean:
- An autoimmune disease such as lupus, rheumatoid arthritis, psoriatic arthritis, or Crohn’s disease and increased risk of developing any of these
- C3 protein deficiency, leading to recurrent bacterial infections
- Hemolytic anemia
- Hepatitis (Inflammation of the liver), including Hepatitis A, Hepatitis B, Hepatitis C
- Chronic kidney disease
- Hereditary angioedema
- Liver disease that results from excessive alcohol consumption
- Organ rejections from transplants e.g. kidney transplant
- Malnutrition
- Septicemia (Blood poisoning)
B. Higher than normal levels could mean:
- Heart attack and other heart problems
- Certain type of cancers
- Ulcerative colitis
- Thyroid disease
- Sarcoidosis (Inflammatory disease)
FAQs on C5 Complement
A blood sample is collected by inserting a fine needle in a vein in your arm. Usually, the entire process does not take more than 5 minutes.
This test involves negligible risk. Slight tenderness or soreness might develop at the place where the needle was inserted. This usually resolves on its own after a while. Rarely, the sight can become infected. Some people may experience temporary dizziness or fainting after their blood is taken.
Results of this test can be available within couple of days to a week’s time (usually 2-6 days). Test results might be mailed or made available online through health portals. Your doctor might also contact you by phone or email to go over your test findings or to arrange a follow-up appointment.
Prior to ordering individual complement component assays, the total complement assay should be used as a screen for potential complement deficiencies. There will be no detectable total complement level if any one of the complement cascade's individual components is lacking.
C5 protein deficiency is a recessive autosomal defect, associated with recurrent bacterial infections, generally caused by Gram-negative bacteria.
C5 Complement
