Anti-Desmoglein I Antibody (DSG I) Test
About Anti-Desmoglein I Antibody test
The anti-desmoglein I antibody test is used to identify the presence of anti-desmoglein I antibodies in the serum sample.
Desmoglein, a protein found in the skin cells, plays a crucial role in cell adhesion. When antibodies against desmoglein are present, the binding between cells weakens, leading to the formation of blisters. This phenomenon is frequently observed in an autoimmune disorder known as pemphigus foliaceus. In pemphigus foliaceus, the body produces antibodies targeting desmoglein 1, which is naturally present in the skin cells. The purpose of this test is to identify the presence of desmoglein 1 antibodies.
Thus, getting this test done is recommended to aid in the diagnosis of pemphigus foliaceus.
Symptoms of pemphigus foliaceus
Blisters on the chest, back and shoulders
Blisters are soft and break open easily
Blisters and sores cause itchiness and pain
Why is the Anti-Desmoglein I Antibody test done?
The anti-desmoglein I antibody test is used
As a screening test for individuals suspected to have an autoimmune blistering disorder of the skin
To diagnose pemphigus foliaceus
To monitor treatment response in individuals with pemphigus foliaceus
Test preparation
In order to prevent the occurrence of lipemic serum (visible turbidity in serum sample due to lipoprotein particles), it is recommended that patients either fast overnight or wait for at least one hour after consuming a meal before having their blood drawn.
Interpretation of test results
The anti-desmoglein I antibody test results are available as either positive or negative.
Positive test results
A positive test result indicates the presence of antibodies to the desmoglein 1 in the serum sample. If the results obtained have a value of 20 RU/ml (relative units/millilitre) or higher, additional tests must be conducted to confirm the disease diagnosis.
Negative test results
A negative test result (<20 RU/mL) indicates the absence of antibodies to the desmoglein 1 in the serum sample.
FAQs
How is the sample collected for an anti-desmoglein I antibody test?
A blood sample is collected from a vein in your arm using a small needle. Usually, this procedure does not take more than 5 minutes.
What is the turnaround time (TAT) for anti-desmoglein I antibody test?
The anti-desmoglein I antibody test result is usually available within the same day after the sample collection. This duration may vary depending upon the diagnostic clinic.
Are there any risks associated with anti-desmoglein I antibody test?
This test involves negligible risk. There might be slight soreness or tenderness around the site where the blood is drawn. Rarely, the site can become infected.
What causes pemphigus foliaceus?
Pemphigus foliaceus, being an autoimmune disease, arises when the body's antibodies mistakenly attack its own tissues. This condition can be attributed to various factors, including genetics, sun exposure, insect bites and the side effects of certain medications such as non-steroidal anti-inflammatory drugs.
Is pemphigus foliaceus contagious?
Pemphigus foliaceus is not a contagious condition, therefore it cannot be passed on to others through physical contact.
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