AML Panel Deletion/Duplication Detection Test: Booking, Price, and Results
About AML Panel Deletion/Duplication Detection Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | AML Del/Dup Panel, AML Copy Number Variation (CNV) Panel, AML Genetic Panel Test |
| Sample Type | Bone marrow aspirate (preferred) or peripheral blood (EDTA tube) |
| Fasting Required | No |
| Report Time | 15 days |
| Recommended For | Adults and children with suspected or confirmed AML; all genders |
| Price | Starting at ₹10,800 |
What Is an AML Panel Deletion/Duplication Detection Test?
The AML panel deletion/duplication detection test is a specialised genetic test used in the evaluation of acute myeloid leukaemia (AML), a type of blood cancer. It identifies missing or extra segments of DNA in genes associated with AML, helping doctors understand how the disease may behave and which treatments are likely to work best. Also known as the AML Del/Dup Panel or AML Copy Number Variation Panel, it uses bone marrow or peripheral blood as the sample. This test is typically ordered by a haematologist or oncologist.
What Does an AML Panel Deletion/Duplication Detection Test Measure?
The AML panel deletion/duplication detection test analyses a large set of genes for specific genetic changes. The method used is MLPA (Multiplex Ligation-dependent Probe Amplification), which detects deletions and duplications across targeted gene regions.
The panel covers the following types of genetic changes:
| Category | Examples |
|---|---|
| Gene mutations (single-nucleotide changes and small insertions or deletions) | NPM1, CEBPA, FLT3, DNMT3A, IDH1, IDH2, RUNX1, TP53, ASXL1, TET2, KRAS, NRAS, WT1, and others |
| Gene deletions (missing DNA segments) | Deletions in regions such as chromosome 7q; changes in BCOR, EZH2, PHF6, and others |
| Gene duplications (extra DNA copies) | FLT3 internal tandem duplications (repeated segments within the FLT3 gene) |
| Fusion genes (abnormal joining of two genes) | ABL1, RARA, RUNX1, MYH11, KMT2A, and others |
Why Is an AML Panel Deletion/Duplication Detection Test Done?
Doctors order this test to understand the genetic makeup of AML cells. This information helps classify the disease, estimate its likely course, and select the most appropriate treatment.
Common Symptoms That May Require This Test
A doctor may order this test when a patient shows signs that suggest AML. The following symptoms are common reasons for further investigation:
- Persistent tiredness or weakness without a clear cause
- Pale skin or looking unusually washed out
- Breathlessness during normal daily activities
- Unexplained high temperature, sweating, or repeated infections
- Easy bruising, frequent nosebleeds, or bleeding gums
- Unexplained weight loss
- Bone pain or tenderness
Conditions This Test Can Help Detect
This test is used in the assessment and ongoing management of several blood-related conditions. It can help with:
- Diagnosis and classification of acute myeloid leukaemia
- Risk stratification (grouping patients by likely disease severity: favourable, intermediate, or adverse)
- Selection of post-remission therapy based on genetic findings
- Monitoring treatment response in patients already receiving therapy
- Detection of disease relapse
AML Panel Deletion/Duplication Detection Test for Chronic Disease Monitoring
AML patients receiving treatment may need this test more than once. It is used most often at the time of diagnosis, but doctors also order it to assess how well treatment is working or to detect signs of relapse. Repeat testing helps track changes in the genetic profile of disease cells over time, supporting decisions about ongoing therapy.
How to Prepare and What to Expect
No special preparation is needed before this test, but there are a few practical steps that will help the process go smoothly.
Do You Need to Fast?
No fasting is required for the AML panel deletion/duplication detection test procedure. You may eat and drink normally before your appointment.
Practical Tips Before Your Test
Keep the following in mind before arriving for sample collection:
- Bring a detailed clinical history, including your symptoms, previous test results, and disease phase (diagnostic, remission, or relapse), as this is required for the test
- If you have received a haematopoietic stem cell transplant, inform the collection team and your doctor in advance
- Let your doctor know about all medications you are currently taking
- Ensure you are adequately hydrated on the day of the procedure
- Wear comfortable clothing that allows easy access to the hip area
Step-by-Step Procedure
This test requires sample collection at a clinical centre by a trained healthcare professional. Two sample types are collected: bone marrow and peripheral blood.
Bone Marrow Sample Collection:
- You will be asked to lie down. The doctor will clean and numb the skin over the hip bone using a local anaesthetic injection to minimise discomfort.
- Once the area is numb, the doctor inserts a specialised needle into the bone and gently rotates it to draw out a small liquid marrow sample (aspiration) and a tiny core of bone tissue (biopsy).
- The procedure takes around 15 to 30 minutes. Some pressure or brief discomfort is normal; mild bone pain may continue for a day or two afterwards.
Peripheral Blood Sample Collection:
- A trained phlebotomist will clean a vein in your arm, usually at the inner elbow.
- A small blood sample (approximately 3 ml) is drawn into an EDTA (lavender-top) tube.
- Both samples are labelled, stored at 2 to 8 degrees Celsius, and dispatched to a specialised molecular genetics laboratory for MLPA analysis.
Factors That Can Affect Accuracy
Certain factors may influence how reliably the test detects genetic changes:
- A low blast percentage (a small proportion of leukaemia cells in the sample) can reduce detection sensitivity
- Poor sample quality due to inadequate aspiration may affect results
- Prior chemotherapy or a stem cell transplant can alter the genetic profile of cells
- An incomplete or missing clinical history may affect how results are interpreted
Understanding Your AML Panel Deletion/Duplication Detection Test Results
Results are reported as either "detected" or "not detected" for each genetic change analysed. Your doctor will review the findings alongside your clinical history, blood counts, and other test results. Report delivery takes up to 15 days, given the complexity of the analysis.
| Finding | Meaning |
|---|---|
| No deletions or duplications detected | No disease-causing copy number changes found in the genes tested |
| Deletions or duplications detected | Specific genetic changes identified; requires review by your doctor |
Findings are generally grouped into three risk categories used by international guidelines (European LeukemiaNet):
| Risk Category | Example Genetic Findings |
|---|---|
| Favourable | Mutant NPM1 with low or absent FLT3-ITD; bi-allelic CEBPA mutation |
| Intermediate | High allele burden FLT3-ITD with mutant NPM1 |
| Adverse | Mutated RUNX1, ASXL1, or TP53; deletions in chromosome 7q |
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
If a sufficient bone marrow sample cannot be obtained, peripheral blood may be used, provided enough leukaemia blast cells are present in circulation. Results from peripheral blood samples should be interpreted with this limitation in mind. Additionally, if you have recently received chemotherapy or a stem cell transplant, your oncologist will factor this into the interpretation, as these treatments can alter the genetic makeup of remaining cells.
How to Maintain Healthy Levels
For patients undergoing AML treatment, the following general steps support overall well-being:
- Attend all scheduled follow-up appointments and repeat tests as recommended by your oncologist
- Maintain open communication with your healthcare team about any new or changing symptoms
- Follow your oncologist's guidance on nutrition, rest, and activity during treatment
Lupin Diagnostics AML Panel Deletion/Duplication Detection Test Price
The AML panel deletion/duplication detection test is available at Lupin Diagnostics starting at ₹10,800. This test requires a visit to a Lupin Diagnostics centre, as home collection is not available for this test.
| City | Approximate Price (₹) |
|---|---|
| Mumbai | 10800 |
| Pune | 10800 |
| Bangalore | 10800 |
| Chennai | 10800 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Follow these steps to book your AML panel deletion/duplication detection test online with Lupin Diagnostics:
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred centre location.
- Visit the centre at your scheduled time for sample collection.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Frequently Asked Questions
The AML panel deletion/duplication detection test is a genetic test that looks for missing or extra segments of DNA in genes linked to acute myeloid leukaemia. It helps doctors understand the disease better and choose the most suitable treatment. The test analyses dozens of genes in a single panel using MLPA technology.
Genetic testing gives doctors critical information about how AML is likely to behave and respond to treatment. At the time of diagnosis, it supports risk classification and helps determine whether standard chemotherapy, targeted therapy, or a stem cell transplant is most appropriate. Without this information, treatment planning would be much less precise.
Bone marrow aspirate is the preferred sample, collected during a standard bone marrow aspiration and biopsy procedure. If bone marrow cannot be obtained, peripheral blood may be used as an alternative, provided a sufficient number of leukaemia cells are present in the blood.
The area is numbed with a local anaesthetic before the needle is inserted, so most people feel pressure rather than sharp pain during the procedure. Some patients experience mild bone pain or soreness at the site in the days following collection. The discomfort is temporary and usually settles within a short time.
The AML panel deletion/duplication detection test has a report delivery time of up to 15 days. This is because the sample undergoes detailed molecular analysis in a specialised laboratory. Your doctor will review the report and discuss the findings with you once it is ready.
No, this test cannot be done at home. Bone marrow sample collection must be performed by a trained doctor in a clinical setting. If you are unsure which centre near you offers this test, you can check the Lupin Diagnostics website for the nearest available location.
A detected finding does not automatically confirm a serious outcome. The result must be reviewed alongside your full clinical picture, including other blood tests and your medical history. Your oncologist will explain what the specific genetic change means for your risk category and how it will influence your treatment plan.
AML Panel Deletion/Duplication Detection Test: Booking, Price, and Results
