Double Marker Reflex to NIPT
Double Marker Reflex to NIPT
This test is used to determine the risk of chromosomal abnormalities in the fetus. It aids in the screening of chromosomal abnormalities and genetic disorders in the fetus during pregnancy.
Therefore, it is recommended for expectant mothers to get this test done to evaluate the potential risk of their baby having a chromosomal disorder
What is Double Marker Reflex to NIPT used for?
Double Marker Reflex to NIPT in pregnant women helps to identify the risk for:
Trisomy 21 (Down syndrome)
Trisomy 18 (Edward’s syndrome)
What tests are included in the Double Marker Reflex to NIPT?
The blood sample is tested for:
• Free Beta hCG (Human Chorionic Gonadotropin):
-
This hormone is produced by the placenta. In pregnant women whose fetus has Down syndrome, the hCG level tends to be higher. Conversely, in fetuses with Edward’s syndrome, the hCG levels are lower
Pregnancy associated plasma protein (PAPP-A):
-
It is initially synthesized by the developing placenta. Throughout the course of a typical pregnancy, the concentration of this protein gradually rises in the bloodstream of the expectant mother until childbirth. A decrease in PAPP-A levels is commonly observed in Down syndrome or Edwards syndrome
Who should get tested?
This test is recommended for pregnant women who are at high risk of having a child with chromosomal abnormality. The following factors can increase the risk of genetic abnormality in the fetus:
Advanced maternal age (>35 years)
History of infertility
History of stillbirths
Nutritional deficiencies (e.g. iron)
Diabetes
Hypothyroidism
Infections (e.g. rubella, syphilis)
Alcohol consumption
Obesity
Smoking
Consanguinity
Genetic factors
Preparation for Test
No special preparation is required for the Double Marker Reflex to NIPT.
Interpretation of Test Results
If the Double Marker Reflex to NIPT result is abnormal, there may be an increased risk of chromosomal disorders such as Down syndrome or Edward’s syndrome. However, this result does not definitively indicate the presence of a disorder. NIPT is typically conducted only when the Double Marker result suggests a high risk of chromosomal disorder. Additional diagnostic tests, such as chorionic villus sampling (CVS) or amniocentesis, are necessary to confirm the diagnosis.
Negative (normal result)
If the Double Marker Reflex to NIPT result is normal, it indicates a decreased likelihood of chromosomal abnormalities. It is important to note that this outcome does not ensure the absence of genetic abnormalities in the baby. Rather, it indicates a lower risk based on the screening conducted.
FAQs
How is the sample collected for a Double Marker Reflex to NIPT?
A blood sample is collected from a vein in your arm using a small needle. Usually, this procedure does not take more than 5 minutes
What are the risks involved in a Double Marker Reflex to NIPT?
This test involves negligible risk. There might be slight pain or tenderness around the site where the needle went in. Rarely, the site can become infected
What is the turnaround time (TAT) for the results of a Double Marker Reflex to NIPT?
Results of a Double Marker Reflex to NIPT are usually available within 3-7 days. This duration may vary depending on the particular diagnostic clinic
When is Double Marker Reflex to NIPT performed?
This test is typically done between the 10th and 13th weeks of pregnancy which provides an early indication of the likelihood of chromosomal abnormalities
Why is it necessary to get a Double Marker Reflex to NIPT done?
Double Marker Reflex to NIPT test aids in early detection of abnormalities in fetuses and determines if further testing is required. Early detection allows for specialized prenatal treatment and regular monitoring of fetus health
Related tests
Non-invasive Prenatal Test (NIPT)
₹ 9,990-
Includes
1 Test Parameter(s)
-
Non-Invasive Prenatal Test (NIPT) or Non-Invasive Prenatal Screening is a highly sensitive and simple blood screening test that analyses genetic information to identify a baby’s risk for several genetic disorders and abnormalities, such as Down syndrome (a chromosomal disorder causing developmental and intellectual delay), Patau syndrome (a genetic disorder where a person has an extra chromosome 13), and Edwards syndrome (a chromosomal disorder with delayed growth and development), Klinefelter syndrome (a chromosomal condition in boys and men affecting physical & intellectual development) and Turner’s syndrome (a chromosomal disorder in girls that affects their development). NIPT is generally recommended to women based on the family history of pregnancy with chromosomal abnormalities or when the woman is over 35 years and older during pregnancy. NIPT test is recommended after 10 weeks of gestation. This test is highly accurate and is considered non-invasive as it involves only testing for a mother's blood sample without posing any risk to the foetus. NIPT is also used for aneuploidy (abnormal number of chromosomes), chromosomal aneuploidies—especially trisomy (an extra copy of a chromosome), or monosomy (a missing chromosome). NIPT next-generation sequencing (NGS) is a highly sensitive and specific approach to screen for fetal aneuploidy. This technology analyses cfDNA fragments across the whole genome.
Tests At Lupin Diagnostics
First Trimester - Triple marker (PLGF)
₹ 3,000-
Includes
1 Test Parameter(s)
Complete Blood Count (CBC)
₹ 280-
Includes
1 Test Parameter(s)
-
Complete blood count (CBC) is a type of blood test that helps determine an individual's overall health. This test evaluates red blood cells that carry oxygen from the lungs to the rest of the body and white blood cells , which fight infections and other diseases. There are five major types of white blood cells, and the CBC test measures the total number of white cells in the blood.CBC test includes an absolute and differential count of basophil, eosinophil, lymphocyte, monocyte, and neutrophil that measures the levels of these cells in the blood. CBC also measures the levels of platelets, which help prevent and stop bleeding. Hemoglobin is a protein in red blood cells, and the Mean corpuscular hemoglobin (MCH) test measures the average amount of hemoglobin in each red blood cell, mean corpuscular hemoglobin concentration (MCHC) test determines the average concentration of hemoglobin in a single red blood cell (RBC). Hematocrit/ Packed Cell Volume (PCV) measures the proportion of red blood cells, and red cell distribution width (RDW) evaluates the differences in the volume and size of your red blood cells. Mean corpuscular volume (MCV) measures the average size of the red blood cells. Complete blood counts can help detect various disorders, including infections, anemia, and diseases affecting blood components.
Beta -hCG, Random Urine
₹ 600-
Includes
1 Test Parameter(s)
-
The Beta-hCG Random Urine test is a pregnancy test. Human chorionic gonadotropin (hCG) is also known as pregnancy hormone since it is produced by the placenta of a pregnant woman. hCG can be detected in urine as early as 7 days after conception. hCG levels often rise rapidly during the first 8 to 10 weeks of pregnancy. Around the tenth week of pregnancy hCG levels are maximum, and then progressively decrease until delivery.