Unconjugated Estriol (uE3) Test
Unconjugated Estriol (uE3) Test
The Unconjugated Estriol (uE3) Test is a prenatal screening test used to measure levels of estriol, a form of estrogen produced by the placenta and fetal liver. This hormone plays a crucial role in pregnancy and fetal development. Low or abnormal uE3 levels may indicate potential chromosomal abnormalities such as Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), or neural tube defects.
The uE3 test is commonly included in maternal serum screening panels, such as the Triple Screen and Quadruple Screen, which help assess the risk of fetal anomalies. Although abnormal results do not confirm a disorder, they indicate the need for further diagnostic testing, including ultrasound or amniocentesis.
What is the Unconjugated Estriol (uE3) Test Used For?
- Assessing fetal well-being and placental function.
- Screening for chromosomal abnormalities, including Down syndrome and Edwards syndrome.
- Monitoring high-risk pregnancies for potential complications.
- Evaluating fetal liver function and development.
Preparation for the Test
No fasting required for the test. A blood sample is drawn from a vein and sent for laboratory analysis. Inform your doctor about any medications or hormonal treatments, as they may affect results.
Interpretation of Test Results
Abnormal results require follow-up testing, including ultrasound, amniocentesis, or genetic counseling.
Low uE3- May indicate Down syndrome, Edwards syndrome, or fetal distress. Further testing is required.
Normal uE3- Suggests a low risk of chromosomal abnormalities.
High uE3- May be associated with multiple pregnancies or advanced gestation.
FAQs
Is a low uE3 level a definitive diagnosis of a genetic disorder?
No, low levels indicate an increased risk but require confirmatory testing.
When is the uE3 test performed during pregnancy?
Typically, between 15 to 20 weeks of gestation as part of the Quadruple Screen.
Can medications affect uE3 levels?
Yes, certain hormonal medications or corticosteroids may impact estriol levels.
What should I do if my test result is abnormal?
Consult with a genetic counselor or maternal-fetal medicine specialist for further evaluation.
Can the uE3 test detect neural tube defects?
Yes, low uE3 levels, combined with elevated AFP, may indicate spina bifida or anencephaly.
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