Thrombophilia Profile Comprehensive Test: Booking, Price, and Results
About Thrombophilia Profile Comprehensive Test: Booking, Price, and Results
| Field | Value |
|---|---|
| Also Known As | Thrombophilia Screen, Thrombophilia Panel, Hypercoagulation Panel, Thrombotic Risk Panel |
| Sample Type | Whole blood (EDTA tube), plasma (sodium citrate tube), and serum (SST gel tube) |
| Fasting Required | No fasting required; eat and drink normally before the test |
| Report Time | 5 days |
| Recommended For | Adults of all genders; particularly those with a personal or family history of blood clots or recurrent pregnancy loss |
| Price | Starting at ₹19,500 |
What is a Thrombophilia Profile Comprehensive Test?
The Thrombophilia Profile Comprehensive test is a panel of blood tests that evaluates the underlying causes of increased blood clotting tendency. Thrombophilia refers to a tendency for abnormal blood clot formation, which can be inherited (passed down through families) or acquired (developed over time). The test analyses natural anticoagulant proteins (proteins that normally prevent excessive clotting) and genetic markers to identify specific clotting risk factors. It is also known as the Thrombophilia Screen, Hypercoagulation Panel, or Thrombotic Risk Panel.
What Does a Thrombophilia Profile Comprehensive Test Measure?
Thrombophilia Profile Comprehensive panel evaluates both inherited genetic causes and acquired conditions that raise the risk of abnormal clotting. The following parameters are included.
| Parameter | What It Checks |
|---|---|
| Antithrombin III Activity | How well this natural clot-inhibiting protein is working |
| Protein C Activity | Activity of a protein that switches off certain clotting factors |
| Protein S Free Antigen | Level of free Protein S, which assists Protein C in controlling clotting |
| Factor V Leiden Mutation | Presence of a genetic change that reduces the body's ability to control clotting |
| Prothrombin G20210A Mutation | A gene variant that causes excess production of prothrombin (a clotting protein) |
| MTHFR Mutation (C677T and A1298C) | Variants in a gene that can affect homocysteine levels |
| Lupus Anticoagulant Panel | Detects antibodies linked to autoimmune clotting conditions such as antiphospholipid syndrome |
Why is a Thrombophilia Profile Comprehensive Test Done?
A doctor may request Thrombophilia Profile Comprehensive test when there is reason to suspect an underlying clotting disorder. It is recommended based on clinical symptoms, personal history, or a family history of clotting disorders.
Common Symptoms That May Require This Test
The following symptoms often prompt a doctor to recommend this panel.
- Unexplained swelling or pain in the legs
- Sudden shortness of breath or chest pain without a clear cause
- Recurrent blood clots, especially in people under 50 years of age
- Blood clots forming in unusual locations, such as brain or abdominal veins
- Skin discolouration over affected veins
- Recurrent pregnancy loss
Conditions This Test Can Help Detect
This panel can help identify a range of inherited and acquired clotting disorders.
- Deep vein thrombosis (DVT) — clots in deep veins, typically in the legs
- Pulmonary embolism — a clot that has travelled to the lungs
- Antithrombin, Protein C, or Protein S deficiency
- Activated Protein C resistance caused by the Factor V Leiden variant
- Antiphospholipid syndrome (APS) — an autoimmune condition that raises clotting risk
- Certain inherited genetic variants that may influence homocysteine metabolism
How to Prepare and What to Expect
Preparation for this test requires attention to medications and timing. The steps below explain what to do before and during sample collection.
Do You Need to Fast?
No fasting is required for the Thrombophilia Profile Comprehensive test procedure. You may eat and drink normally before your appointment.
Practical Tips Before Your Test
The following steps will help you get reliable results from this panel:
- Bring a detailed clinical history including your symptoms, previous test results, and family history, as this is required for the test.
- Inform your doctor about all medications you are currently taking, particularly blood thinners such as warfarin, heparin, dabigatran, rivaroxaban, or apixaban. Your doctor may advise pausing certain medications before testing, if medically safe.
- Also mention oral contraceptive pills, hormone replacement therapy, or any hormonal medication, as these can affect natural anticoagulant levels.
- Inform your doctor if you have received recent blood transfusions, plasma products, or anticoagulant reversal agents, as these may affect certain test results.
- Wear a loose-fitting top or a garment with sleeves that can be rolled up easily.
Step-by-Step Procedure
This test requires three blood samples collected from a vein in one sitting:
- A healthcare professional will clean the skin on the inner arm with an antiseptic wipe.
- A tourniquet (an elastic band) is tied around the upper arm to make the veins more visible.
- A fine needle is gently inserted into a suitable vein, and blood is drawn into multiple tubes: a lavender-top EDTA tube, a sky-blue sodium citrate tube, and a yellow SST gel tube.
- The needle is removed, and light pressure is applied to the puncture site using cotton or gauze.
- Samples are labelled and transported according to laboratory protocols to preserve specimen integrity.
- Genetic mutation tests (Factor V Leiden, Prothrombin, and MTHFR) require additional processing, which contributes to the 5-day report turnaround.
Factors That Can Affect Accuracy
Several factors can influence results and should be discussed with your doctor before the test.
- Current use of anticoagulants or blood-thinning medications
- Active blood clot or acute illness at the time of sample collection
- Pregnancy or ongoing hormonal therapy
- Liver disease, which can reduce production of anticoagulant proteins
- Testing too soon after a recent clotting event
- Recent surgery, trauma, prolonged immobilisation, or hospitalisation may influence clotting-related test results
Understanding Your Thrombophilia Profile Comprehensive Test Results
Results from this panel require careful interpretation by a qualified doctor, as several factors can influence individual readings. The table below provides general reference ranges for each parameter.
| Parameter | Normal Range | Unit |
|---|---|---|
| Antithrombin III Activity | 80 to 120 | % |
| Protein C Activity | 70 to 130 | % |
| Protein S Free Antigen (Male) | 77 to 143 | % |
| Protein S Free Antigen (Female) | 55 to 123 | % |
| Anticardiolipin Antibody IgG | Less than 20 | GPL U/ml |
| Anticardiolipin Antibody IgM | Less than 20 | MPL U/ml |
| Beta-2 Glycoprotein I IgG | Less than 20 | SGU U/ml |
| Beta-2 Glycoprotein I IgM | Less than 20 | SMU U/ml |
| Factor V Leiden Mutation | Not Detected | Qualitative |
| Prothrombin G20210A Mutation | Not Detected | Qualitative |
| MTHFR C677T / A1298C | Wild type (no mutation) | Qualitative |
| Lupus Anticoagulant Screen Ratio | Less than 1.20 (Negative) | Ratio |
Disclaimer: These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Certain health states and medications can alter test results, even in people without a true clotting disorder.
- Pregnancy physiologically lowers free Protein S levels and may alter several coagulation parameters, making interpretation of thrombophilia testing more challenging.
- Acute thrombosis, severe infection, inflammatory disorders, or major surgery can temporarily alter antithrombin, Protein C, and Protein S measurements.
- Oral contraceptive pills, oestrogen therapy, tamoxifen, and raloxifene can alter natural anticoagulant levels and compound clotting risk.
- Liver disease reduces production of clotting proteins, which may cause low readings unrelated to inherited thrombophilia.
How to Maintain Healthy Levels
General lifestyle habits can support circulatory health. These are wellness tips, not treatment recommendations:
- Stay physically active and avoid prolonged immobility. During long flights or journeys, stand up and walk around regularly.
- Keep yourself well hydrated, especially during hot weather or when travelling.
- If a clotting disorder is confirmed, speak with your doctor about precautions during high-risk situations such as surgery, long-haul travel, or starting hormonal therapy.
Lupin Diagnostics Thrombophilia Profile Comprehensive Test Price and Home Collection
The Thrombophilia Profile Comprehensive test cost at Lupin Diagnostics starts at ₹19,500, and home collection is available across cities. City-wise indicative prices are listed below.
| City | Approximate Price (₹) |
|---|---|
| BHOPAL | 19500 |
| CHENNAI | 19500 |
| HYDERABAD | 19500 |
| KOLKATA | 19500 |
| NAVI MUMBAI | 19500 |
| PUNE | 19500 |
Disclaimer: Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Booking your Thrombophilia Profile Comprehensive test online is quick and straightforward.
- Select the test on the Lupin Diagnostics website.
- Choose your city and preferred time slot.
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre.
- Receive your report via email or WhatsApp within the stipulated turnaround time.
Home Collection
Thrombophilia Profile Comprehensive test home collection is available across cities, making it easy to have your samples collected at a time and place that suits you. All samples are processed in NABL-accredited laboratories by trained professionals. Digital reports are delivered securely via email or WhatsApp once ready.
Frequently Asked Questions
This panel identifies both inherited genetic mutations and acquired conditions that cause the blood to clot abnormally. It evaluates natural anticoagulant proteins and genetic markers together, helping doctors determine why a person may have experienced unexplained or recurrent blood clots.
It is typically recommended for people who have had unexplained blood clots, especially at a young age or in unusual locations, those with a family history of clotting disorders, or people who have experienced recurrent pregnancy losses. Your doctor will advise whether testing is appropriate for you.
Certain blood thinners, such as warfarin and heparin, can affect the results of functional protein tests. Your doctor may recommend pausing these medications before testing, if it is medically safe to do so. Genetic mutation tests are not affected by medication. Never stop any medication without medical advice.
The report is available within 5 days. Functional assays such as Protein C, Protein S, Antithrombin III, and Lupus Anticoagulant may be processed sooner, while genetic mutation analyses for Factor V Leiden, Prothrombin, and MTHFR require additional laboratory processing time.
Not necessarily. A positive result indicates a raised risk, not a certainty. Many people carry these mutations without ever developing a clot. Your doctor will assess your full medical history and overall risk profile before recommending any course of action.
Different tests in this panel require different sample types. The EDTA tube is used for genetic mutation analysis, the sodium citrate tube is used for clotting-based assays such as Lupus Anticoagulant, and the SST gel tube is used for other protein measurements. Collecting all three in one sitting avoids a repeat visit.
Thrombophilia Profile Comprehensive Test: Booking, Price, and Results
