Thrombophilia Profile, Comprehensive Test
Thrombophilia Profile, Comprehensive Test
The Thrombophilia Profile, Comprehensive is a specialized panel of blood tests used to evaluate an individual's risk for abnormal blood clotting (thrombophilia). Thrombophilia is a condition where the blood has an increased tendency to clot, which can lead to deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, or recurrent pregnancy loss. This profile helps identify genetic and acquired factors contributing to excessive clot formation.
Thrombophilia can be inherited or acquired, making early detection essential for individuals with a family history of blood clots, recurrent miscarriages, or unexplained thrombotic events. Proper diagnosis aids in preventive measures, lifestyle modifications, and treatment decisions to reduce clotting risks.
What is the Thrombophilia Profile Used For?
- Assessing inherited and acquired clotting disorders.
- Identifying genetic mutations linked to thrombophilia.
- Evaluating individuals with recurrent miscarriages or pregnancy complications.
- Determining the cause of unexplained blood clots in veins or arteries.
- Guiding anticoagulant therapy decisions for long-term clot prevention.
Tests Included in the Thrombophilia Profile
Antithrombin Activity (Functional)
-
Measures antithrombin, a protein that inhibits clot formation.
Factor V Leiden Mutation
-
Detects a genetic mutation that increases clotting risk.
Lupus Anticoagulant
-
Screens for antiphospholipid syndrome (APS), a major cause of clotting disorders.
MTHFR Gene Mutation
-
Identifies mutations affecting folate metabolism, which can contribute to clot formation.
Protein C (Functional)
-
- Evaluates the activity of protein C, which helps regulate blood clotting.
Protein S Antigen (Free)
-
Measures protein S, a cofactor for protein C in preventing abnormal clots
Prothrombin Gene Mutation (G20210A)
-
- Checks for a genetic variant linked to increased thrombotic risk.
Symptoms of Thrombophilia
Thrombophilia itself doesn’t cause symptoms but increases the risk of abnormal blood clotting. Symptoms depend on where the clot forms
Deep vein thrombosis (DVT): Leg swelling, pain, redness, and warmth.
Pulmonary embolism (PE): Shortness of breath, chest pain, rapid heartbeat, coughing up blood.
Unusual clot locations: Clots in the brain (stroke), abdomen (severe pain), or arms.
Who Should Take the Test?
- Individuals with a personal or family history of abnormal blood clots (DVT, PE, or stroke).
- Women with recurrent miscarriages, preeclampsia, or unexplained pregnancy complications.
- Patients with blood clotting disorders at a young age (<50 years old).
- Individuals with antiphospholipid syndrome (APS) or unexplained prolonged clotting times.
- Those undergoing anticoagulant therapy to assess clotting risk.
Preparation for the Test
No fasting required is required for the test. Inform your doctor if you are on blood thinners (anticoagulants), as they may affect test results. A blood sample is drawn from a vein and sent for laboratory analysis.
Interpretation of Test Results
Low Antithrombin Activity- Suggests an increased risk of clot formation due to antithrombin deficiency.
Factor V Leiden Mutation Positive- Indicates a genetic predisposition to clotting.
Lupus Anticoagulant Positive- Suggests antiphospholipid syndrome (APS), increasing thrombosis risk.
MTHFR Mutation Detected- May indicate higher homocysteine levels, linked to clotting disorders.
Low Protein C or Protein S- Suggests a deficiency, leading to poor clot regulation.
Prothrombin Gene Mutation Positive- Confirms a genetic predisposition to excessive clot formation.
FAQs
Can thrombophilia be cured?
No, but lifestyle changes, medications, and anticoagulant therapy can manage the condition effectively.
What are the symptoms of thrombophilia?
Symptoms may include leg swelling (DVT), chest pain (PE), recurrent miscarriages, and unexplained strokes.
How long does it take to get results?
Most test results are available within 5 to 10 days, depending on the laboratory.
Does a positive test mean I will develop a blood clot?
Not necessarily. Risk factors like smoking, surgery, pregnancy, and immobility also contribute to clot formation.
What should I do if I test positive for thrombophilia?
Consult a hematologist for personalized management, which may include lifestyle modifications, aspirin therapy, or anticoagulant medications.
Related tests
Tests At Lupin Diagnostics