Ovarian Reserve Profile – Advanced Test
Ovarian Reserve Profile – Advanced Test
The Ovarian Reserve Profile - Advanced test is a comprehensive assessment of a woman's reproductive potential by evaluating key hormones involved in ovarian function. Ovarian reserve refers to the quantity and quality of a woman's eggs, which naturally decline with age. This test helps in fertility evaluation, assisted reproductive technology (ART) planning, and diagnosing reproductive disorders.
Diminished ovarian reserve can lead to irregular menstrual cycles, infertility, and poor response to ovarian stimulation. Identifying these issues early helps guide treatment decisions, including hormone therapy or in-vitro fertilization (IVF) options.
What is the Ovarian Reserve Profile - Advanced Used For?
This test is used to:
- Assess a woman’s egg quantity and quality.
- Evaluate fertility potential before planning conception.
- Monitor ovarian function and aging.
- Guide treatment strategies for infertility.
- Detect early signs of ovarian insufficiency or failure.
Aid in personalized IVF treatment planning.
Hormones Tested in the Ovarian Reserve Profile - Advanced
This profile includes the following tests
Anti-Müllerian Hormone (AMH) - Serum
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A marker of ovarian reserve and follicle count.
Estradiol (E2)
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Evaluates ovarian function and menstrual cycle regularity.
Follicle-Stimulating Hormone (FSH)
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Assesses ovarian response and early ovarian aging.
Inhibin B
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Indicates follicular development and ovarian function.
Luteinizing Hormone (LH)
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Helps regulate ovulation and ovarian hormone production.
Symptoms of Diminished Ovarian Reserve
Women with low ovarian reserve may experience
Irregular or missed menstrual periods.
Difficulty conceiving despite regular attempts.
Shortened menstrual cycles (< 25 days).
Poor response to fertility treatments.
Early menopause symptoms (hot flashes, mood swings, night sweats).
Preparation for the Test
A blood sample is collected for analysis. The test is usually performed on day 2 or 3 of the menstrual cycle. No fasting is required, but certain medications (e.g., birth control pills, hormone therapy) should be discussed with your doctor.
Interpretation of Results
Anti-Müllerian Hormone (AMH) (Best marker for ovarian reserve)
>3.0- High ovarian reserve (often seen in PCOS)
1.0 – 3.0- Normal ovarian reserve
0.5 – 1.0- Reduced ovarian reserve (consider fertility preservation)
<0.5- Very low ovarian reserve (poor fertility potential)
2. Follicle-Stimulating Hormone (FSH) - Cycle Day 2-3
<10- Normal ovarian reserve
10 – 15- Borderline reduced reserve
>15- Poor ovarian reserve (diminished fertility)
High FSH with low AMH suggests low ovarian reserve.
3. Luteinizing Hormone (LH) - Cycle Day 2-3
<7- Normal
>10- May indicate PCOS if LH:FSH ratio is >2:1
4. Estradiol (E2) - Cycle Day 2-3
<50- Normal ovarian function
50 – 80- Borderline reserve (may affect FSH interpretation)
>80- Poor ovarian reserve or ovarian dysfunction
High E2 with high FSH may suggest ovarian aging.
5. Inhibin B (Optional Marker of Follicular Function)
>45- Normal ovarian reserve
<45- Diminished ovarian reserve
Summary of Interpretation
- Normal Ovarian Reserve- Normal AMH, FSH, and Estradiol
- Diminished Ovarian Reserve- Low AMH, High FSH (>15), High Estradiol
- PCOS Indication- High AMH, High LH (>10), Increased LH:FSH Ratio (>2:1)
- Perimenopause/Menopause- Low AMH, High FSH, High Estradiol
FAQs
What does a low AMH level mean?
A low AMH level suggests diminished ovarian reserve, meaning fewer remaining eggs and potential fertility challenges.
Can I improve my ovarian reserve?
While ovarian reserve naturally declines, lifestyle changes like a healthy diet, avoiding smoking, and stress management may help maintain reproductive health.
How does this test help in IVF treatment?
It helps doctors determine the best ovarian stimulation protocol for IVF, improving success rates.
What is the ideal age to check ovarian reserve?
Women considering pregnancy or fertility treatments should test their ovarian reserve before age 35 or earlier if experiencing menstrual irregularities.
Does birth control affect ovarian reserve test results?
Yes, hormonal contraceptives can temporarily lower AMH and FSH levels, so testing should ideally be done after stopping birth control.
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