Factor XI Functional
Factor XI Functional
Factor XI deficiency, is also called hemophilia C, plasma thromboplastin antecedent deficiency, and Rosenthal syndrome. The factor XI functional test assesses the activity of factor XI, a clotting protein involved in the blood coagulation cascade. It measures the ability of factor XI to participate in the formation of blood clots, crucial for proper hemostasis (blood clotting). This test is particularly useful in evaluating bleeding disorders, such as hemophilia C, where deficiencies in factor XI can lead to prolonged bleeding. By analyzing the clotting ability of factor XI, healthcare providers can diagnose and monitor hemophilia C, guiding treatment decisions to prevent excessive bleeding episodes and manage patient care effectively.
Symptoms of factor XI deficiency
Nosebleeds
Easy bruising
Bleeding under the skin
Blood in your urine or stool
Bleeding of the gums
Prolonged bleeding following surgery
Heavy or prolonged menstrual bleeding
Excessive bleeding after childbirth
Repeated miscarriages
Liver problems
Who should get tested?
Factor XI functional test is most often used if you have
A tendency of abnormal bleeding
A family history of factor XI functional deficiency
To undergo a surgical procedure
Liver abnormalities
Preparation for the test
No special preparation is required to undergo factor XI functional test. However, your healthcare provider may advise you to stop certain medications temporarily prior to the test.
Interpretation of test results
The units of measurement for the results are often given as a percentage.
|
Range (Factor XI) |
Interpretation |
|
65% to 130% |
Normal range |
|
20% to 60% |
Mild factor XI deficiency (symptoms may appear) |
|
< 20% |
Severe factor XI deficiency |
Note: Test results may vary based on your age, gender, medical history, and testing laboratory.
Deviation from normal levels indicate the following:
Decreased factor XI activity may indicate the following conditions:
· Factor XI deficiency (a bleeding disorder that occurs due to lack of blood clotting factor XI)
· Disseminated intravascular coagulation (characterized by excessive activity of blood clotting proteins)
· Liver disease
· Vitamin K deficiency
FAQs
How is the sample collected for the factor XI functional test?
During this blood test, a healthcare professional will take a small amount of blood from a vein in your arm using a small needle, which is collected in a test tube or vial. This procedure takes no longer than five minutes.
What are the risks involved in the factor XI functional test?
This test involves negligible risk. During a blood test, one may experience minor pain or bruising where the needle was inserted, but most symptoms will subside quickly.
What is the turnaround time (TAT) for the factor XI functional test results?
The factor XI functional test result is usually available within the same working day as the sample collection. However, the TAT duration may vary depending on the diagnostic clinic.
Can medications affect my factor XI assay results?
Yes, medications such as blood thinners can affect factor XI levels. So, it is important to inform your healthcare provider about any medications you are using prior to the test.
What precautions should individuals with factor XI deficiency take?
Individuals with factor XI deficiency should be cautious and avoid activities that pose a high risk of injury and bleeding. They need to communicate their condition to healthcare professionals before undergoing any surgical or dental procedures.
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