C4 Complement
C4 Complement
The C4 Complement test is done to measure the amount of C4 proteins in the blood. C4 proteins are an important part of your complement system, which provides information about your immune system. C4 protein helps kill disease-causing bacteria and viruses.
The Complement System helps the immune system to produce antibodies and make them more effective. The system eliminates dead cells and other wastes from the body, and recognizes and neutralizes bacteria and viruses.
C4 complement test helps your healthcare provider diagnose autoimmune disorders such as systemic lupus erythematosus (SLE). It also helps keep track of treatment for an autoimmune disease.
C4 Complement test is also known as:
C4, complement antigen, complement activity C4, complement component 4
Symptoms of Systemic Lupus Erythematosus (SLE)
Skin rash (a butterfly rash) across your cheeks
Swollen lymph nodes
Mouth ulcers
Headache
Fever
Fatigue
Joint pain and swelling
Pain in the chest
Weight loss
Hair loss
Hearing loss
Vision loss
What Is a C4 Complement Test Used For?
C4 Complement test is recommended in the following conditions:
Diagnose autoimmune disorders e.g. lupus
Recurrent bacterial infections
Monitor immune complex-related conditions such as glomerulonephritis (GN) and vasculitis
Determine treatment plan for an autoimmune disease
Test preparation
This test does not require any special preparation. However, it is advisable to inform your healthcare provider about all the medicines, vitamins, and supplements you might be taking prior to taking this test
Interpretation of the Test Results
Normal range of C4 proteins is between 16 and 48 milligrams per deciliter (mg/dl). The normal range of C4 proteins usually varies depending on the individual's age, gender, and health history.
Deviations from normal levels indicates the following:
A. Increased C4 complement activity may be seen in:
· Cancer
· Ulcerative colitis
B. Decreased C4 complement activity may be seen in:
· Bacterial infections (especially Neisseria)
· Hepatitis
· Glomerulonephritis
· Cirrhosis
· Hereditary angioedema
· Kidney transplant rejection
· Lupus nephritis
· Systemic lupus erythematosus
· Malnutrition
Rare inherited complement deficiencies
FAQs
Are there any risks associated with C4 Complement test?
Risks associated with this test are slight. These may include excessive bleeding, fainting or lightheadedness, blood accumulating under the skin (hematoma), and sometimes, infection
How is the C4 Complement test performed?
A blood sample is collected by inserting a fine needle in a vein in your arm. Usually, the entire procedure does not take more than 5 minutes
If my C4 complement levels in blood are low, can I increase it by taking some supplements?
Yes, taking supplements like mangosteen can boost your C4 levels. It is recommended to consult with your healthcare provider before adding any new supplements to your routine
What is the turnaround time (TAT) for C4 Complement test?
It usually takes 1-2 working days to obtain the test results for C4 complement test. However, this duration may vary depending upon the clinic
Is C4 bad for my kidneys?
Kidney damage is made worse by the vicious cycle of C4 and inflammatory cells. C4 complement can activate tubular epithelial cells which then produces a microenvironment that promotes inflammation and fibrillation. This leads to end-stage renal disease (ESRD).
Related tests
Tests At Lupin Diagnostics