C2 Complement
C2 Complement
This test is done to measure the amount of C2 proteins in the blood. C2 proteins are an important part of your complement system, which provides information about your immune system. C2 protein helps kill disease-causing bacteria and viruses.
The Complement System helps the immune system to produce antibodies and make them more effective. The system eliminates dead cells and other wastes from the body, and recognizes and neutralizes bacteria and viruses.
C2 complement test helps your healthcare provider diagnose autoimmune disorders such as systemic lupus erythematosus (SLE). It also helps keep track of treatment for an autoimmune disease.
C2 Complement test is also known as:
C2, complement antigen, complement C2, complement component 2
Symptoms of Systemic Lupus Erythematosus (SLE)
Skin rash (a butterfly rash) across your cheeks
Swollen lymph nodes
Mouth ulcers
Headache
Fever
Fatigue
Joint pain and swelling
Pain in the chest
Weight loss
Hair loss
Hearing loss
Vision loss
What is a C2 Complement Test Used for?
C2 Complement test is recommended in the following conditions:
Diagnose autoimmune disorders e.g. lupus
Recurrent bacterial infections
Monitor immune complex-related conditions such as glomerulonephritis (GN) and vasculitis
Determine treatment plan for an autoimmune disease
Test preparation
A fasting sample is preferred but not necessarily required for C2 Complement test.
Interpretation of the Test Results
Normal range of C2 proteins varies between 25 and 47 unit/mL (U/mL).
Deviations from normal levels indicates the following:
A. Increased C2 complement activity may be seen in:
· Scleroderma
· Polymyositis
· Rheumatoid arthritis
· Behcet disease
· Aortitis syndrome
B. Decreased C2 complement activity may be seen in:
· Bacterial infections (especially Neisseria)
· Hepatitis
· Glomerulonephritis
· Cirrhosis
· Hereditary angioedema
· Kidney transplant rejection
· Lupus nephritis
· Systemic lupus erythematosus
· Malnutrition
· Rare inherited complement deficiencies
FAQs
Are there any risks associated with C2 complement test?
Risks associated with this test are slight. There may be slight bruise or tenderness around the area where the needle was inserted. This usually resolves on its own in a few hours or a couple of days.
How is the C2 complement test performed?
This test requires small quantity of blood to be drawn by inserting a fine needle in a vein in the arm. The entire process gets over within 5 minutes
What is the turnaround time (TAT) for C2 complement test?
It takes usually 2-4 working days to obtain the test results for C2 complement test. However, this duration may vary depending upon the diagnostic clinic
What causes C2 deficiency?
Both genetic and environmental factors are said to play a role in causing C2 deficiency. Generally, this condition is inherited as an autosomal recessive pattern, meaning both copies of the gene in each cell undergoes mutation
How can a person with hereditary C2 deficiency lead a normal life?
If diagnosed early, hereditary C2 deficient person can lead a normal life by the use of vaccinations and antibiotic prophylaxis
Related tests
Tests At Lupin Diagnostics