Anti-MOG (MYELIN OLIGODENDROCYTE GLYCOPROTEIN) ANTIBODY, CSF Test
About Anti-MOG Antibody, CSF test
The anti-MOG antibody test is a diagnostic test used to detect the presence of antibodies against myelin oligodendrocyte glycoprotein (MOG) in the cerebrospinal fluid (CSF). MOG is a protein found on the surface of myelin, which is the protective covering of nerve fibres in the central nervous system (CNS).
The test is primarily used in the diagnosis of various neurological disorders such as transverse myelitis, optic neuritis, neuromyelitis optica spectrum disorder (NMOSD) and other related disorders.
Thus, getting this test done is recommended to diagnose various neurological diseases.
Symptoms of Anti-MOG Antibody-associated diseases
The symptoms of anti-MOG antibody-associated diseases may differ based on the specific condition. Following are some common symptoms
Loss of vision or blurred vision
Pain in or behind the eyes
Dizziness
Weakness or paralysis in the arms or legs
Numbness or tingling sensation in the arms or legs
Lack of control over bladder or bowel movements
Why is the Anti-MOG Antibody test done?
The anti-MOG antibody test is used to
Diagnose various neurological abnormalities
Distinguish between NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis at an early stage for proper treatment
Test preparation
No special preparation is required for the anti-MOG antibody test.
Interpretation of test results
The anti-MOG antibody test results are available as either positive or negative.
Positive test results
A positive test result indicates the presence of antibodies to the MOG in the CSF sample.
Negative test results
A negative test result indicates the absence of antibodies to the MOG in the CSF sample.
FAQs
How is the sample collected for an anti-MOG antibody test?
CSF for anti-MOG antibody testing is collected through a lumbar puncture, commonly known as a spinal tap. A needle is inserted into the spinal canal to obtain CSF. The collected fluid is then analyzed to detect the presence of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies, aiding in diagnosing neurological disorders.
What is the turnaround time (TAT) for anti-MOG antibody test?
The anti-MOG antibody test results are usually available within the same day after the sample collection. However, this duration may vary depending upon the diagnostic clinic.
Are there any risks associated with anti-MOG antibody test?
The anti-MOG antibody cerebrospinal fluid (CSF) test is generally safe but may pose some risks, including pain and swelling at site of needle insertion.
How does the CSF test for anti-MOG antibodies differ from other neurological tests?
The CSF test for anti-MOG antibodies specifically looks for the presence of these antibodies in the cerebrospinal fluid. Other neurological tests, such as magnetic resonance imaging (MRI) and clinical evaluations, may be used alongside the CSF test to assess the patient's condition comprehensively.
Can anti-MOG antibody levels fluctuate over time, and is monitoring necessary after diagnosis?
Anti-MOG antibody levels can fluctuate, and ongoing monitoring may be necessary to assess disease activity and treatment response. Regular follow-up with healthcare providers and repeated testing may be recommended.
Related tests
Tests At Lupin Diagnostics