Anti-DNAse B (Deoxyribonuclease B) Test
About Anti-DNAse B (Deoxyribonuclease B) Test
| Field | Value |
|---|---|
| Also Known As | ADNase-B, ADN-B, ADB, Antideoxyribonuclease B Titre, Anti-Streptococcal DNase B Antibodies, DNase-B Antibodies |
| Sample Type | Venous blood (serum) |
| Fasting Required | Not required; an 8-hour fast is preferred but optional |
| Report Time | 1 to 4 working days |
| Recommended For | All ages and genders; commonly used in children aged 5 to 15 years following a suspected streptococcal infection |
| Price | Starting at ₹1,800 |
What Is an Anti-DNAse B (Deoxyribonuclease B) Test?
The Anti-DNAse B test detects antibodies that your immune system produces against a protein released by Group A Streptococcus bacteria, the germs responsible for strep throat and certain skin infections. A blood sample is drawn from a vein in your arm and analysed in a laboratory.
This test is also called the antideoxyribonuclease B test, ADNase-B test, or DNase B antibody test, and doctors use it when they suspect a past streptococcal infection may have led to complications.
What Does an Anti-DNAse B (Deoxyribonuclease B) Test Measure?
The ADN-B titer test measures the level of Anti-DNase B antibodies in the blood. These antibodies can remain detectable for weeks or months after a streptococcal infection has cleared, making this test particularly useful for identifying past exposure.
| Component | What It Tells You |
|---|---|
| Anti-DNAse B Antibodies | Confirms whether the immune system has responded to Group A Streptococcus bacteria |
| Antibody Titre Level | Indicates whether antibody levels are within the normal range for your age group or elevated above it |
Why Is an Anti-DNAse B (Deoxyribonuclease B) Test Done?
Doctors order this test when they need to confirm whether a patient has had a recent or past streptococcal infection, especially if complications are suspected.
Common Symptoms That May Require This Test
- Sore throat or throat pain (strep throat)
- Joint pain or swelling in the ankles, knees, wrists, or elbows
- Fever that does not subside
- Skin rash or sores (such as impetigo)
- Dark or cola-coloured urine
- Swelling around the eyes, hands, or feet
- Unusual fatigue or shortness of breath
Conditions This Test Can Help Detect
- Recent or past Group A Streptococcus infection
- Rheumatic fever (inflammation affecting the heart, joints, and nervous system)
- Post-streptococcal glomerulonephritis (inflammation of the kidney's tiny filtering units following a strep infection)
- Streptococcal skin infections such as impetigo, where other antibody tests may not show elevated levels
How to Prepare and What to Expect
Getting ready for an ADNase-B blood test is straightforward. Here is everything you need to know before your appointment.
Do You Need to Fast?
Fasting is not required for this test. You can eat and drink normally beforehand. Some laboratories may prefer an 8-hour fast, but this is optional. If your doctor has ordered additional tests at the same time, check whether any of those require fasting.
Practical Tips Before Your Test
- Inform your doctor about any recent infections, antibiotics taken, or when your symptoms began
- Wear a half-sleeved top or loose clothing for easy access to your arm
- Stay well-hydrated before your appointment
- Continue any prescribed medications unless your doctor advises otherwise
Step-by-Step Procedure
- A trained phlebotomist cleans the inner surface of your arm with an antiseptic solution.
- A small needle is inserted into a vein. You may feel a brief prick or mild stinging sensation.
- A small amount of blood is drawn into a collection tube.
- The needle is removed and light pressure is applied to the site. Minor bruising or throbbing may follow, but this fades quickly.
- Your sample is labelled and dispatched to the laboratory.
- The laboratory analyses the sample using nephelometry (a technique that measures how light scatters through the sample) or ELISA (an antibody-detection method).
Factors That Can Affect Accuracy
- Testing too early, as antibodies typically peak 4 to 6 weeks after infection
- Sample contamination during transport or storage, which may produce falsely high readings
- High fat (lipid) levels in the blood, which can interfere with light-based analysis methods
- Liver disease, where elevated lipoproteins in the blood may mimic antibody activity
Understanding Your Anti-DNAse B (Deoxyribonuclease B) Test Results
Your results should always be reviewed with a doctor who can place them in the context of your symptoms and health history. The table below shows the general reference ranges used for the ADN-B titer test.
| Age Group | Normal Range | Unit |
|---|---|---|
| Adults (18 years and above) | Less than 85 | units/milliliter (mL) |
| School-age children (5 to 17 years) | Less than 170 | units/mL |
| Preschool children (under 5 years) | Less than 60 | units/mL |
These ranges are general guidelines. Your doctor will interpret your results based on your age, health history, and other factors. Always consult a qualified healthcare professional for personalised medical advice.
Results During Special Conditions
Liver disease may cause elevated lipoprotein levels in the blood, which can mimic antibody activity and produce falsely high results. Children, particularly school-age children, naturally have higher average antibody levels than adults, so age-specific reference ranges must be applied when interpreting results in younger patients.
How to Prevent Streptococcal Infections
These general wellness tips may help reduce the risk of streptococcal infections:
- Wash your hands frequently, especially after contact with someone who is unwell
- Seek prompt medical attention for any sore throat or skin sores that do not heal quickly
- If prescribed antibiotics for a strep infection, complete the full course as directed by your doctor
Lupin Diagnostics Anti-DNAse B (Deoxyribonuclease B) Test Price and Home Collection
The Anti-DNAse B test price at Lupin Diagnostics starts at approximately ₹1,800, with home collection available across cities. The table below provides city-wise indicative pricing for the Anti DNAse B test.
| City | Approximate Price (₹) |
|---|---|
| Mumbai | ₹1,800 |
| Bangalore | ₹1,800 |
| Chennai | ₹1,800 |
| Hyderabad | ₹1,800 |
| Kolkata | ₹1,800 |
| Bhopal | ₹1,800 |
| Pune | ₹1,800 |
| Indore | ₹1,800 |
Prices are indicative and may vary by location. Please confirm the current price at the time of booking.
How to Book
Searching for 'anti DNAse B test near me'? Booking your test is easy through Lupin Diagnostics:
- Select the test on the Lupin Diagnostics website
- Choose your city and preferred time slot
- Opt for home sample collection by a certified phlebotomist, or visit your nearest Lupin Diagnostics centre
- Receive your report via email or WhatsApp within the stipulated turnaround time
Home Collection
Lupin Diagnostics offers home sample collection across major Indian cities, so you can get your ADNase-B test done without visiting a centre. All samples are processed in NABL-accredited laboratories by experienced technologists. Your digital report is delivered directly to your email or WhatsApp.
Frequently Asked Questions
The Anti-DNAse B test is done to confirm whether a person has had a recent streptococcal infection. It is particularly useful when a doctor suspects complications such as rheumatic fever or post-streptococcal kidney inflammation (glomerulonephritis).
Both tests detect antibodies to Group A Streptococcus bacteria, but they target different proteins. The ADNase-B test is especially useful when a skin infection such as impetigo is suspected, as the ASO test often shows normal levels in such cases. When used together, the two tests can identify more than 90% of past streptococcal infections.
Antibody levels usually reach their highest point around 4 to 6 weeks after a streptococcal infection. Testing too soon after an infection may not capture elevated antibody levels.
These antibodies typically begin to decline around 3 months after the original illness, but they can remain elevated and detectable for several months to a year. Because they persist in the blood much longer than other streptococcal markers, a positive result can easily be detected long after your initial throat or skin symptoms have fully resolved.
No, fasting is not required before this test. You may eat and drink as usual before your appointment. Some laboratories prefer an 8-hour fast, so check with your doctor or the collection centre if you are unsure.
A positive result indicates elevated antibody levels, suggesting the body has responded to a Group A Streptococcus infection. Your doctor will review the result alongside your symptoms and medical history to determine whether further investigation is needed.
Yes. The ADB test is commonly ordered for children, particularly those aged 5 to 15 years. Children in this age group tend to have naturally higher antibody levels than adults, so results are interpreted using age-specific reference ranges.
Anti-DNAse B (Deoxyribonuclease B) Test
