Factor IX Functional
Factor IX Functional
Factor IX, also known as coagulating factor IX, is a clotting protein that is synthesized within the body. Its primary function is to regulate and control bleeding in case of an injury. A shortage of this particular protein typically signifies a bleeding disorder known as hemophilia B. Individuals with a deficiency in factor IX often experience uncontrollable bleeding following any form of injury. Thus, getting this test done is recommended to identify if a person is suffering from factor IX deficiency.
Symptoms of hemophilia B
Bleeding from mucous membranes (e.g. Inside the gastrointestinal tract)
Bleeding into muscles (e.g. Under the skin)
Bruising easily
Heavy menstrual bleeding
Nosebleeds that do not stop easily
Blood in urine or stool
Mouth bleeds (e.g. from gums during dental treatment)
What is the Factor IX Functional test used for?
Factor IX functional test is most often used if you have
A tendency of abnormal bleeding
A family history of factor IX functional deficiency
Liver abnormalities
Preparation for the test
No special preparations are required to undergo the factor IX functional test. Before this test, you may temporarily need to stop taking certain medicines as advised by your healthcare provider.
Interpretation of results
The units of measurement for the results are often given as a percentage.
Normal plasma levels of factor IX range from 50% to 150%.
Deviations from normal levels indicate the following:
Decreased factor IX activity may be caused by:
· Hemophilia B (a bleeding disorder that impairs the blood clotting ability)
· Disseminated intravascular coagulation (characterized by excessive activity of blood clotting proteins)
· Liver disease (such as cirrhosis)
· Vitamin K deficiency
· Taking blood thinners
FAQs
How is the sample collected for the factor IX functional test?
During this test, a small amount of blood is taken from a vein in your arm using a needle, which is collected in a test tube or vial. This procedure takes no longer than five minutes.
What are the risks associated with the factor IX functional test?
This test involves negligible risk. During a blood test, one may experience minor pain or bruising at the site where the needle was inserted, but most symptoms will subside quickly.
What is the turnaround time (TAT) for this test?
Factor IX functional test results are usually available within the same working day as the sample collection. However, this duration may vary depending on the diagnostic clinic.
What causes hemophilia B?
Hemophilia B is caused by mutations in the F9 gene, which normally directs the production of coagulation factor IX protein.
How is hemophilia B managed?
Hemophilia B is treated through the administration of clotting factor replacement therapy. This involves the infusion of factor IX concentrates directly into the bloodstream via an intravenous route. Individuals with hemophilia B should avoid engaging in activities that pose a high risk of injury. Furthermore, they should exercise caution when using medications that may affect the clotting process.
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